FGF10 fibroblast growth factor 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FGF10provided by HGNC
Official Full Name: fibroblast growth factor 10provided by HGNC
Primary source: HGNC:HGNC:3666
See related: Ensembl:ENSG00000070193 MIM:602115; AllianceGenome:HGNC:3666
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LADD3
Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]
Expression: Broad expression in ovary (RPKM 9.2), fat (RPKM 4.7) and 15 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5p12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (44300247..44389420, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (44553832..44642982, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (44300349..44389522, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FGF10 attenuates allergic airway inflammation in asthma by inhibiting PI3K/AKT/NF-kappaB pathway.
Title: FGF10 attenuates allergic airway inflammation in asthma by inhibiting PI3K/AKT/NF-κB pathway.
FGF10/FGFR2 Signaling: Therapeutically Targetable Vulnerability in Ligand-responsive Cholangiocarcinoma Cells.
Title: FGF10/FGFR2 Signaling: Therapeutically Targetable Vulnerability in Ligand-responsive Cholangiocarcinoma Cells.
Fibroblast growth factor 10 attenuates chronic obstructive pulmonary disease by protecting against glycocalyx impairment and endothelial apoptosis.
Title: Fibroblast growth factor 10 attenuates chronic obstructive pulmonary disease by protecting against glycocalyx impairment and endothelial apoptosis.
FGF10 promotes cardiac repair through a dual cellular mechanism increasing cardiomyocyte renewal and inhibiting fibrosis.
Title: FGF10 promotes cardiac repair through a dual cellular mechanism increasing cardiomyocyte renewal and inhibiting fibrosis.
Deletion of the last two exons of FGF10 in a family with LADD syndrome and pulmonary acinar hypoplasia.
Title: Deletion of the last two exons of FGF10 in a family with LADD syndrome and pulmonary acinar hypoplasia.
FGF10/FGF17 as prognostic and drug response markers in acute myeloid leukemia.
Title: FGF10/FGF17 as prognostic and drug response markers in acute myeloid leukemia.
Inhibition of FGF10-ERK signal activation suppresses intraductal papillary neoplasm of the bile duct and its associated carcinomas.
Title: Inhibition of FGF10-ERK signal activation suppresses intraductal papillary neoplasm of the bile duct and its associated carcinomas.
Association study of fibroblast growth factor 10 (FGF10) rs399501 polymorphism with susceptibility to high myopia in a Chinese population.
Title: Association study of fibroblast growth factor 10 (FGF10) rs399501 polymorphism with susceptibility to high myopia in a Chinese population.
Association of fibroblast growth factor 10 with the fibrotic and inflammatory pathogenesis of Graves' orbitopathy.
Title: Association of fibroblast growth factor 10 with the fibrotic and inflammatory pathogenesis of Graves' orbitopathy.
Mutations in fibroblast growth factor (FGF8) and FGF10 identified in patients with conotruncal defects.
Title: Mutations in fibroblast growth factor (FGF8) and FGF10 identified in patients with conotruncal defects.

Submit: New GeneRIF Correction See all GeneRIFs (75)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Congenital absence of salivary gland MedGen: C0158667 OMIM: 180920 GeneReviews: Not available	Compare labs
Lacrimoauriculodentodigital syndrome 3 MedGen: C5774287 OMIM: 620193 GeneReviews: Not available	not available

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2022-02-23) ClinGen Genome Curation Page Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2022-02-23) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Microarray analysis indicates HIV-1 Tat-induced upregulation of fibroblast growth factor 10 (FGF10) in primary human brain microvascular endothelial cells	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:481074

SHGC-82302 (e-PCR)
- UniSTS:104243

NoName (e-PCR)
- UniSTS:483140

Fgf10 (e-PCR), detects polymorphism
- UniSTS:536432

G16001 (e-PCR)
- UniSTS:11918

SHGC-100998 (e-PCR)
- UniSTS:183961

SHGC-110572 (e-PCR)
- UniSTS:167910

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chemoattractant activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemoattractant activity	IDA Inferred from Direct Assay more info	PubMed
enables fibroblast growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables type 2 fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 2 fibroblast growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in Harderian gland development	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in blood vessel remodeling	IEA Inferred from Electronic Annotation more info
involved_in branch elongation involved in salivary gland morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in branching morphogenesis of an epithelial tube	IDA Inferred from Direct Assay more info	PubMed
involved_in bronchiole morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in bud elongation involved in lung branching	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bud outgrowth involved in lung branching	IDA Inferred from Direct Assay more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in determination of left/right symmetry	IEA Inferred from Electronic Annotation more info
involved_in embryonic camera-type eye development	IEA Inferred from Electronic Annotation more info
involved_in embryonic digestive tract morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic genitalia morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic pattern specification	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in epithelial cell proliferation involved in salivary gland morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in establishment of mitotic spindle orientation	IEA Inferred from Electronic Annotation more info
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info
involved_in female genitalia morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in hair follicle morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in induction of positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in lacrimal gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in limb bud formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung epithelium development	IDA Inferred from Direct Assay more info	PubMed
involved_in lung proximal/distal axis specification	IEA Inferred from Electronic Annotation more info
involved_in lung saccule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male genitalia morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in mammary gland bud formation	IEA Inferred from Electronic Annotation more info
involved_in mesenchymal cell differentiation involved in lung development	IEA Inferred from Electronic Annotation more info
involved_in mesenchymal-epithelial cell signaling involved in lung development	IEA Inferred from Electronic Annotation more info
involved_in mesonephros development	IEP Inferred from Expression Pattern more info	PubMed
involved_in metanephros development	IEP Inferred from Expression Pattern more info	PubMed
involved_in metanephros morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in muscle cell fate commitment	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of stem cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in odontogenesis of dentin-containing tooth	IEA Inferred from Electronic Annotation more info
involved_in organ induction	IEA Inferred from Electronic Annotation more info
involved_in otic vesicle formation	IEA Inferred from Electronic Annotation more info
involved_in pancreas development	IEA Inferred from Electronic Annotation more info
involved_in pituitary gland development	IEA Inferred from Electronic Annotation more info
involved_in positive chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ATP-dependent activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Ras protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epithelial cell proliferation involved in wound healing	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of hair follicle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of keratinocyte migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of keratinocyte proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of lymphocyte proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of stem cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of urothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of urothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of white fat cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in prostatic bud formation	IEA Inferred from Electronic Annotation more info
involved_in protein localization to cell surface	IDA Inferred from Direct Assay more info	PubMed
involved_in radial glial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of activin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of saliva secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of smoothened signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in salivary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in secretion by lung epithelial cell involved in lung growth	IDA Inferred from Direct Assay more info	PubMed
involved_in semicircular canal fusion	IEA Inferred from Electronic Annotation more info
involved_in smooth muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in somatic stem cell population maintenance	IEA Inferred from Electronic Annotation more info
involved_in spleen development	IEA Inferred from Electronic Annotation more info
involved_in stem cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in submandibular salivary gland formation	IEA Inferred from Electronic Annotation more info
involved_in tear secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thymus development	IDA Inferred from Direct Assay more info	PubMed
involved_in thyroid gland development	IEA Inferred from Electronic Annotation more info
involved_in tissue regeneration	IEA Inferred from Electronic Annotation more info
involved_in type II pneumocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in urothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in white fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in white fat cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in wound healing	IBA Inferred from Biological aspect of Ancestor more info
involved_in wound healing	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	NAS Non-traceable Author Statement more info	PubMed
colocalizes_with collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fibroblast growth factor 10

Names: FGF-10; keratinocyte growth factor 2; produced by fibroblasts of urinary bladder lamina propria

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.