MAPK15 mitogen-activated protein kinase 15 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MAPK15provided by HGNC
Official Full Name: mitogen-activated protein kinase 15provided by HGNC
Primary source: HGNC:HGNC:24667
See related: Ensembl:ENSG00000181085 MIM:618616; AllianceGenome:HGNC:24667
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ERK7; ERK8
Summary: Enables MAP kinase activity and chromatin binding activity. Involved in several processes, including dopamine uptake; positive regulation of DNA metabolic process; and regulation of organelle organization. Located in several cellular components, including Golgi apparatus; autophagosome; and microtubule organizing center. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in lung (RPKM 5.3), testis (RPKM 4.6) and 9 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q24.3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (143716349..143722458)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (144872787..144878895)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (144798519..144804628)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitogen-Activated Protein Kinase 15 Is a New Predictive Biomarker and Potential Therapeutic Target for Ovarian Cancer.
Title: Mitogen-Activated Protein Kinase 15 Is a New Predictive Biomarker and Potential Therapeutic Target for Ovarian Cancer.
MAPK15 protects from oxidative stress-dependent cellular senescence by inducing the mitophagic process.
Title: MAPK15 protects from oxidative stress-dependent cellular senescence by inducing the mitophagic process.
MAPK15-ULK1 signaling regulates mitophagy of airway epithelial cell in chronic obstructive pulmonary disease.
Title: MAPK15-ULK1 signaling regulates mitophagy of airway epithelial cell in chronic obstructive pulmonary disease.
As multiple roles of MAPK15 were observed among these studies, therefore, it remains unclear whether MAPK15 acts as a proto-oncogene or tumor suppressor. Here, the recent literature on human MAPK15 and the resulting functions will be discussed.
Title: Regulation of human mitogen-activated protein kinase 15 (extracellular signal-regulated kinase 7/8) and its functions: A recent update.
MAPK15 stimulates ULK1, is part of the ULK complex, colocalizes in autophagosomes, and is involved in autophagosome biogenesis.
Title: MAPK15 is part of the ULK complex and controls its activity to regulate early phases of the autophagic process.
Our results describe a primary cilia-related role for this poorly studied member of the MAPK family in vivo, and indicate a broad requirement for MAPK15 in the formation of multiple ciliary classes across species.
Title: Primary Cilium Formation and Ciliary Protein Trafficking Is Regulated by the Atypical MAP Kinase MAPK15 in Caenorhabditis elegans and Human Cells.
High MAPK15 expression is associated with male germ cell tumors.
Title: MAPK15 upregulation promotes cell proliferation and prevents DNA damage in male germ cell tumors.
In HeLa cells, phosphorylation of HuR by ERK8 prevents it from binding to PDCD4 mRNA and allows miR-21-mediated degradation of PDCD4.
Title: ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism.
depletion of endogenous MAPK15 expression inhibited BCR-ABL1-dependent cell proliferation, in vitro
Title: MAPK15 mediates BCR-ABL1-induced autophagy and regulates oncogene-dependent cell proliferation and tumor formation.
The present study suggests that MAPK15 overexpression may contribute to the malignant transformation of gastric mucosa by prolonging the stability of c-Jun.
Title: Overexpression of MAPK15 in gastric cancer is associated with copy number gain and contributes to the stability of c-Jun.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 binding to CD4 results in activation of the mitogen-activated protein kinase (MAPK) in CD4(+) lymphocytes prestimulated through their T-cell receptor (TCR)	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables SH3 domain binding	NAS Non-traceable Author Statement more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in dopamine uptake	IDA Inferred from Direct Assay more info	PubMed
involved_in endoplasmic reticulum organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of metaphase/anaphase transition of meiosis I	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of spindle assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of telomerase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of telomerase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of telomere capping	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of telomere capping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of telomere maintenance via telomerase	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of telomere maintenance via telomerase	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to ciliary transition zone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of COPII vesicle coating	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cilium assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in autophagosome	IDA Inferred from Direct Assay more info	PubMed
NOT located_in axoneme	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
located_in meiotic spindle	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mitogen-activated protein kinase 15

Names: ERK-7; ERK-8; MAP kinase 15; MAPK 15; extracellular regulated kinase 8 delta; extracellular signal-regulated kinase 7; extracellular signal-regulated kinase 8

NP_620590.2

EC 2.7.11.24

XP_011515227.1

EC 2.7.11.24

XP_011515228.1

EC 2.7.11.24

XP_011515229.1

EC 2.7.11.24

XP_011515230.1

EC 2.7.11.24

XP_047277522.1

EC 2.7.11.24

XP_047277523.1

EC 2.7.11.24

XP_047277524.1

EC 2.7.11.24

XP_054184724.1

EC 2.7.11.24

XP_054184725.1

EC 2.7.11.24

XP_054184726.1

EC 2.7.11.24

XP_054184727.1

EC 2.7.11.24

XP_054184728.1

EC 2.7.11.24

XP_054184729.1

EC 2.7.11.24

XP_054184730.1

EC 2.7.11.24

XP_054216067.1

EC 2.7.11.24

XP_054216068.1

EC 2.7.11.24

XP_054216069.1

EC 2.7.11.24

XP_054216070.1

EC 2.7.11.24

XP_054216071.1

EC 2.7.11.24

XP_054216072.1

EC 2.7.11.24

XP_054216073.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139021.3 → NP_620590.2 mitogen-activated protein kinase 15

See identical proteins and their annotated locations for NP_620590.2

Status: VALIDATED

Source sequence(s)

AY065978, BP357805

Consensus CDS

CCDS6409.2

UniProtKB/Swiss-Prot

Q2TCF9, Q8N362, Q8TD08

Related

ENSP00000337691.4, ENST00000338033.9

Conserved Domains (2) summary

smart00220
Location:13 → 304

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07852
Location:5 → 343

STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

143716349..143722458

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011516926.3 → XP_011515228.1 mitogen-activated protein kinase 15 isoform X2

See identical proteins and their annotated locations for XP_011515228.1

Conserved Domains (2) summary

smart00220
Location:13 → 323

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07852
Location:5 → 362

STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
XM_047421567.1 → XP_047277523.1 mitogen-activated protein kinase 15 isoform X5
XM_047421568.1 → XP_047277524.1 mitogen-activated protein kinase 15 isoform X6
XM_011516925.3 → XP_011515227.1 mitogen-activated protein kinase 15 isoform X1

See identical proteins and their annotated locations for XP_011515227.1

Conserved Domains (2) summary

smart00220
Location:25 → 325

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07852
Location:25 → 364

STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
XM_047421566.1 → XP_047277522.1 mitogen-activated protein kinase 15 isoform X4
XM_011516927.3 → XP_011515229.1 mitogen-activated protein kinase 15 isoform X3

See identical proteins and their annotated locations for XP_011515229.1

Conserved Domains (2) summary

smart00220
Location:25 → 306

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07852
Location:25 → 345

STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
XM_011516928.3 → XP_011515230.1 mitogen-activated protein kinase 15 isoform X7

See identical proteins and their annotated locations for XP_011515230.1

Conserved Domains (2) summary

smart00220
Location:25 → 325

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07852
Location:25 → 327

STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs