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MON1B MON1 homolog B, secretory trafficking associated [ Homo sapiens (human) ]

Gene ID: 22879, updated on 5-Mar-2024

Summary

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Official Symbol
MON1Bprovided by HGNC
Official Full Name
MON1 homolog B, secretory trafficking associatedprovided by HGNC
Primary source
HGNC:HGNC:25020
See related
Ensembl:ENSG00000103111 MIM:608954; AllianceGenome:HGNC:25020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRG1; HSRG1; SAND2
Summary
Involved in early viral transcription and late viral transcription. Located in cytoplasm. Part of Mon1-Ccz1 complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 20.4), thyroid (RPKM 15.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
16q23.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (77191190..77202398)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (83247364..83258572)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (77225087..77236295)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903724 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_44883 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:77098253-77098456 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:77113401-77113619 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_44931 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_44984 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_45056 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_45073 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_45133 Neighboring gene MPRA-validated peak2646 silencer Neighboring gene uncharacterized LOC124903725 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:77224805-77225753 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_45171 Neighboring gene uncharacterized LOC124903726 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:77246135-77247108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11151 Neighboring gene synaptonemal complex central element protein 1 like Neighboring gene vomeronasal 2 receptor 10, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein encoded by HSV-1 stimulation-related gene 1 (HSRG1) interacts with and inhibits SV40 large T antigen. Guo HX, et al. Cell Prolif, 2006 Dec. PMID 17109635, Free PMC Article
  2. Identification of a novel human sand family protein in human fibroblasts induced by herpes simplex virus 1 binding. Dong S, et al. Acta Virol, 2003. PMID 12828340
  3. Numb regulates vesicular docking for homotypic fusion of early endosomes via membrane recruitment of Mon1b. Shao X, et al. Cell Res, 2016 May. PMID 26987402, Free PMC Article
  4. HSV-1 stimulation-related protein HSRG1 inhibits viral gene transcriptional elongation by interacting with Cyclin T2. Wu W, et al. Sci China Life Sci, 2011 Apr. PMID 21509660
  5. Systematic Analysis of Human Cells Lacking ATG8 Proteins Uncovers Roles for GABARAPs and the CCZ1/MON1 Regulator C18orf8/RMC1 in Macroautophagic and Selective Autophagic Flux. Vaites LP, et al. Mol Cell Biol, 2018 Jan 1. PMID 29038162, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Numb binds to another docking regulator, Mon1b, and is required for the recruitment of cytosolic Mon1b to the early endosomes membrane.
    Title: Numb regulates vesicular docking for homotypic fusion of early endosomes via membrane recruitment of Mon1b.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.
  3. HSRG1 interacts with SV40 large T antigen (LT) in yeast two-hybrid assay
    Title: Protein encoded by HSV-1 stimulation-related gene 1 (HSRG1) interacts with and inhibits SV40 large T antigen.
  4. Identification of HSV-1 stimulation-related gene 1, a novel sand family protein, induced by herpes simplex virus 1 binding. (HSV-1 stimulation-related gene 1 (HSRG1)
    Title: Identification of a novel human sand family protein in human fibroblasts induced by herpes simplex virus 1 binding.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in early viral transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in late viral transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein targeting to vacuole IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Mon1-Ccz1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Mon1-Ccz1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
vacuolar fusion protein MON1 homolog B
Names
HSV-1 stimulation-related gene 1 protein
HSV-I stimulating-related protein
MON1 secretory trafficking family member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286639.2 → NP_001273568.1  vacuolar fusion protein MON1 homolog B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC009139
    Consensus CDS
    CCDS67083.1
    UniProtKB/TrEMBL
    B4DKA0, E7EW32
    Related
    ENSP00000404053.2, ENST00000439557.6
    Conserved Domains (1) summary
    pfam03164
    Location:48 → 416
    Mon1; Trafficking protein Mon1

  2. NM_001286640.2 → NP_001273569.1  vacuolar fusion protein MON1 homolog B isoform 3

    See identical proteins and their annotated locations for NP_001273569.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC009139
    Consensus CDS
    CCDS67082.1
    UniProtKB/TrEMBL
    Q6ZR87
    Related
    ENSP00000444881.1, ENST00000545553.1
    Conserved Domains (1) summary
    pfam03164
    Location:9 → 379
    Mon1; Trafficking protein Mon1

  3. NM_014940.4 → NP_055755.1  vacuolar fusion protein MON1 homolog B isoform 1

    See identical proteins and their annotated locations for NP_055755.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC009139
    Consensus CDS
    CCDS10925.1
    UniProtKB/Swiss-Prot
    B4DDZ0, O94949, Q7L1V2
    UniProtKB/TrEMBL
    B3KN76
    Related
    ENSP00000248248.3, ENST00000248248.8
    Conserved Domains (1) summary
    pfam03164
    Location:108 → 525
    Mon1; Trafficking protein Mon1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    77191190..77202398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    83247364..83258572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7L1V2.1 GenPept UniProtKB/Swiss-Prot:Q7L1V2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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