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Kmt2c lysine (K)-specific methyltransferase 2C [ Mus musculus (house mouse) ]

Gene ID: 231051, updated on 12-May-2024

Summary

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Official Symbol
Kmt2cprovided by MGI
Official Full Name
lysine (K)-specific methyltransferase 2Cprovided by MGI
Primary source
MGI:MGI:2444959
See related
Ensembl:ENSMUSG00000038056 AllianceGenome:MGI:2444959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HALR; Mll3; E330008K23Rik
Summary
Predicted to enable histone binding activity; histone methyltransferase activity (H3-K4 specific); and transcription coactivator activity. Involved in histone methylation. Acts upstream of or within several processes, including eyelid development in camera-type eye; positive regulation of fibroblast proliferation; and single fertilization. Predicted to be located in nucleus. Predicted to be part of MLL3/4 complex. Is expressed in several structures, including eye; genitourinary system; limb; nervous system; and neural ectoderm. Human ortholog(s) of this gene implicated in Klatskin's tumor; Kleefstra syndrome 2; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human KMT2C (lysine methyltransferase 2C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 7.3), whole brain E14.5 (RPKM 6.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Kmt2c in Genome Data Viewer
Location:
5 B1; 5 12.35 cM
Exon count:
63
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (25476793..25703853, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (25271795..25498855, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5 Neighboring gene STARR-seq mESC enhancer starr_12661 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 11 Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 3 Neighboring gene sperm associated antigen 7 pseudogene Neighboring gene RIKEN cDNA 4831440E17 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:25015100-25015283 Neighboring gene predicted gene, 22656

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of Kmt2c in vivo leads to EMT, mitochondrial dysfunction and improved response to lapatinib in breast cancer. Simigdala N, et al. Cell Mol Life Sci, 2023 Mar 18. PMID 36933062, Free PMC Article
  2. Circadian clock function does not require the histone methyltransferase MLL3. Baxter M, et al. FASEB J, 2022 Jul. PMID 35704036, Free PMC Article
  3. Loss of Mll3 Catalytic Function Promotes Aberrant Myelopoiesis. Arcipowski KM, et al. PLoS One, 2016. PMID 27610619, Free PMC Article
  4. Histone methyltransferase MLL3 contributes to genome-scale circadian transcription. Valekunja UK, et al. Proc Natl Acad Sci U S A, 2013 Jan 22. PMID 23297224, Free PMC Article
  5. Characterization and expression analysis during embryo development of the mouse ortholog of MLL3. Brun ME, et al. Gene, 2006 Apr 12. PMID 16459028

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Macromolecular Complex Including MLL3, Carabin and Calcineurin Regulates Cardiac Remodeling.
    Title: Macromolecular Complex Including MLL3, Carabin and Calcineurin Regulates Cardiac Remodeling.
  2. MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.
    Title: MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.
  3. Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.
    Title: Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.
  4. Loss of Kmt2c in vivo leads to EMT, mitochondrial dysfunction and improved response to lapatinib in breast cancer.
    Title: Loss of Kmt2c in vivo leads to EMT, mitochondrial dysfunction and improved response to lapatinib in breast cancer.
  5. KMT2C deficiency promotes small cell lung cancer metastasis through DNMT3A-mediated epigenetic reprogramming.
    Title: KMT2C deficiency promotes small cell lung cancer metastasis through DNMT3A-mediated epigenetic reprogramming.
  6. Circadian clock function does not require the histone methyltransferase MLL3.
    Title: Circadian clock function does not require the histone methyltransferase MLL3.
  7. KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis.
    Title: KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis.
  8. Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy.
    Title: Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy.
  9. Long non-coding RNA DANCR regulate MLL3 and thereby it determines the progression of pancreatic cancer.
    Title: Long non-coding RNA DANCR regulate MLL3 and thereby it determines the progression of pancreatic cancer.
  10. MLL4 is required after implantation, whereas MLL3 becomes essential during late gestation.
    Title: MLL4 is required after implantation, whereas MLL3 becomes essential during late gestation.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1506

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K4 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K4 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K4 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables histone H3K4 monomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within eyelid development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within single fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MLL3/4 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MLL3/4 complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of histone methyltransferase complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
histone-lysine N-methyltransferase 2C
Names
histone-lysine N-methyltransferase MLL3
myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog
NP_001074852.1
XP_006535745.1
XP_006535746.1
XP_006535748.1
XP_006535749.1
XP_006535751.1
XP_006535752.1
XP_006535753.1
XP_006535755.1
XP_006535756.1
XP_006535757.1
XP_006535759.1
XP_006535760.1
XP_006535761.1
XP_006535762.1
XP_006535763.1
XP_006535764.1
XP_006535766.1
XP_011248068.1
XP_017176308.1
XP_017176309.1
XP_017176310.1
XP_017176311.1
XP_017176312.1
XP_017176313.1
XP_017176314.1
XP_017176315.1
XP_030110235.1
XP_036020903.1
XP_036020904.1
XP_036020905.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081383.2 → NP_001074852.1  histone-lysine N-methyltransferase 2C

    Status: VALIDATED

    Source sequence(s)
    AC116469, AC127319, AC134910
    Consensus CDS
    CCDS39033.1
    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    UniProtKB/TrEMBL
    F8WI37
    Related
    ENSMUSP00000043874.8, ENSMUST00000045291.14
    Conserved Domains (18) summary
    smart00317
    Location:4765 → 4886
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:4888 → 4904
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:4718 → 4904
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    sd00025
    Location:1078 → 1100
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:342 → 387
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:465 → 516
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:1003 → 1049
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:389 → 434
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:946 → 1002
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1080 → 1130
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:246 → 329
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4395 → 4499
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam05964
    Location:4545 → 4595
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4601 → 4682
    FYRC; F/Y rich C-terminus
    pfam07223
    Location:3271 → 3562
    DUF1421; Protein of unknown function (DUF1421)
    pfam11176
    Location:1682 → 1765
    DUF2962; Protein of unknown function (DUF2962)
    pfam15233
    Location:3175 → 3251
    SYCE1; Synaptonemal complex central element protein 1
    cl00082
    Location:1644 → 1695
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    25476793..25703853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249766.3 → XP_011248068.1  histone-lysine N-methyltransferase 2C isoform X29

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1789 → 2279
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1039 → 1061
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343 → 388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466 → 517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:964 → 1010
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390 → 435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1041 → 1091
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247 → 330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4250 → 4354
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam01576
    Location:3101 → 3183
    Myosin_tail_1; Myosin tail
    pfam03154
    Location:3197 → 3499
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4399 → 4450
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4456 → 4540
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1608 → 1691
    Tma16; Translation machinery-associated protein 16
    cd19171
    Location:4602 → 4754
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1570 → 1621
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cl22851
    Location:907 → 963
    PHD_SF; PHD finger superfamily

  2. XM_036165012.1 → XP_036020905.1  histone-lysine N-methyltransferase 2C isoform X28

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (16) summary
    smart00398
    Location:1643 → 1696
    HMG; high mobility group
    PHA03247
    Location:1864 → 2354
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1079 → 1101
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343 → 388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466 → 517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:1004 → 1050
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390 → 435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:947 → 1003
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1081 → 1131
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247 → 330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4451 → 4555
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam09606
    Location:3275 → 3559
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd19171
    Location:4803 → 4955
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    pfam05964
    Location:4600 → 4651
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4657 → 4741
    FYRC; F/Y rich C-terminus
    pfam13868
    Location:3171 → 3258
    TPH; Trichohyalin-plectin-homology domain

  3. XM_006535682.4 → XP_006535745.1  histone-lysine N-methyltransferase 2C isoform X1

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1880 → 2370
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1079 → 1101
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343 → 388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466 → 517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:1004 → 1050
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390 → 435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:947 → 1003
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1081 → 1131
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247 → 330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4467 → 4571
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3288 → 3590
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4616 → 4667
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4673 → 4757
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1699 → 1782
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3189 → 3275
    PKK; Polo kinase kinase
    cd19171
    Location:4823 → 4975
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1661 → 1712
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  4. XM_017320819.2 → XP_017176308.1  histone-lysine N-methyltransferase 2C isoform X3

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1879 → 2369
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1078 → 1100
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343 → 388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466 → 517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:1003 → 1049
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390 → 435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:946 → 1002
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1080 → 1130
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247 → 330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4466 → 4570
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3287 → 3589
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4615 → 4666
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4672 → 4756
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1698 → 1781
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3188 → 3274
    PKK; Polo kinase kinase
    cd19171
    Location:4822 → 4974
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1660 → 1711
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  5. XM_006535697.4 → XP_006535760.1  histone-lysine N-methyltransferase 2C isoform X19

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1789 → 2279
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1039 → 1061
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343 → 388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466 → 517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:964 → 1010
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390 → 435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:907 → 963
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1041 → 1091
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247 → 330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4376 → 4480
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3197 → 3499
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4525 → 4576
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4582 → 4666
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1608 → 1691
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3098 → 3184
    PKK; Polo kinase kinase
    cd19171
    Location:4732 → 4884
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1570 → 1621
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  6. XM_017320824.2 → XP_017176313.1  histone-lysine N-methyltransferase 2C isoform X18

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1824 → 2314
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1039 → 1061
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343 → 388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466 → 517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:964 → 1010
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390 → 435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:907 → 963
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1041 → 1091
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247 → 330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4411 → 4515
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3232 → 3534
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4560 → 4611
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4617 → 4701
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1643 → 1726
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3133 → 3219
    PKK; Polo kinase kinase
    cd19171
    Location:4767 → 4919
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1605 → 1656
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  7. XM_006535694.4 → XP_006535757.1  histone-lysine N-methyltransferase 2C isoform X15

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1840 → 2330
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1039 → 1061
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343 → 388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466 → 517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:964 → 1010
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390 → 435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:907 → 963
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1041 → 1091
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247 → 330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4427 → 4531
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3248 → 3550
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4576 → 4627
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4633 → 4717
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1659 → 1742
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3149 → 3235
    PKK; Polo kinase kinase
    cd19171
    Location:4783 → 4935
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1621 → 1672
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  8. XM_006535696.4 → XP_006535759.1  histone-lysine N-methyltransferase 2C isoform X17

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1829 → 2319
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1079 → 1101
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343 → 388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466 → 517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:1004 → 1050
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390 → 435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:947 → 1003
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1081 → 1131
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247 → 330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4416 → 4520
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3237 → 3539
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4565 → 4616
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4622 → 4706
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1648 → 1731
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3138 → 3224
    PKK; Polo kinase kinase
    cd19171
    Location:4772 → 4924
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1610 → 1661
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  9. XM_006535689.4 → XP_006535752.1  histone-lysine N-methyltransferase 2C isoform X10

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1864 → 2354
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1079 → 1101
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343 → 388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466 → 517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:1004 → 1050
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390 → 435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:947 → 1003
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1081 → 1131
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247 → 330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4451 → 4555
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3272 → 3574
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4600 → 4651
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4657 → 4741
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1683 → 1766
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3173 → 3259
    PKK; Polo kinase kinase
    cd19171
    Location:4807 → 4959
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1645 → 1696
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  10. XM_017320826.2 → XP_017176315.1  histone-lysine N-methyltransferase 2C isoform X25

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1880 → 2370
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1079 → 1101
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343 → 388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466 → 517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:1004 → 1050
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390 → 435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:947 → 1003
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1081 → 1131
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247 → 330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4317 → 4421
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3288 → 3590
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4466 → 4517
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4523 → 4607
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1699 → 1782
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3189 → 3275
    PKK; Polo kinase kinase
    cd19171
    Location:4669 → 4821
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1661 → 1712
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  11. XM_006535701.4 → XP_006535764.1  histone-lysine N-methyltransferase 2C isoform X24

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1880 → 2370
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1079 → 1101
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343 → 388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466 → 517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:1004 → 1050
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390 → 435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:947 → 1003
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1081 → 1131
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247 → 330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4317 → 4421
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3288 → 3590
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4466 → 4517
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4523 → 4607
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1699 → 1782
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3189 → 3275
    PKK; Polo kinase kinase
    cd19171
    Location:4673 → 4825
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1661 → 1712
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  12. XM_017320825.2 → XP_017176314.1  histone-lysine N-methyltransferase 2C isoform X23

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1880 → 2370
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1079 → 1101
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343 → 388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466 → 517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:1004 → 1050
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390 → 435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:947 → 1003
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1081 → 1131
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247 → 330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4340 → 4444
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3288 → 3590
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4489 → 4540
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4546 → 4630
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1699 → 1782
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3189 → 3275
    PKK; Polo kinase kinase
    cd19171
    Location:4692 → 4844
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1661 → 1712
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  13. XM_006535699.4 → XP_006535762.1  histone-lysine N-methyltransferase 2C isoform X21

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1880 → 2370
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1079 → 1101
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343 → 388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466 → 517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:1004 → 1050
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390 → 435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:947 → 1003
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1081 → 1131
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247 → 330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4340 → 4444
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3288 → 3590
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4489 → 4540
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4546 → 4630
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1699 → 1782
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3189 → 3275
    PKK; Polo kinase kinase
    cd19171
    Location:4696 → 4848
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1661 → 1712
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  14. XM_006535700.4 → XP_006535763.1  histone-lysine N-methyltransferase 2C isoform X22

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1880 → 2370
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1079 → 1101
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343 → 388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466 → 517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:1004 → 1050
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390 → 435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:947 → 1003
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1081 → 1131
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247 → 330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4341 → 4445
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3288 → 3590
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4490 → 4541
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4547 → 4631
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1699 → 1782
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3189 → 3275
    PKK; Polo kinase kinase
    cd19171
    Location:4693 → 4845
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1661 → 1712
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  15. XM_006535698.4 → XP_006535761.1  histone-lysine N-methyltransferase 2C isoform X20

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1880 → 2370
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1079 → 1101
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343 → 388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466 → 517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:1004 → 1050
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390 → 435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:947 → 1003
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1081 → 1131
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247 → 330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4341 → 4445
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3288 → 3590
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4490 → 4541
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4547 → 4631
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1699 → 1782
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3189 → 3275
    PKK; Polo kinase kinase
    cd19171
    Location:4697 → 4849
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1661 → 1712
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  16. XM_017320823.2 → XP_017176312.1  histone-lysine N-methyltransferase 2C isoform X13

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1880 → 2370
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1079 → 1101
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343 → 388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466 → 517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:1004 → 1050
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390 → 435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:947 → 1003
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1081 → 1131
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247 → 330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4442 → 4546
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3288 → 3590
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4591 → 4642
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4648 → 4732
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1699 → 1782
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3189 → 3275
    PKK; Polo kinase kinase
    cd19171
    Location:4798 → 4950
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1661 → 1712
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  17. XM_017320821.2 → XP_017176310.1  histone-lysine N-methyltransferase 2C isoform X8

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1880 → 2370
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1079 → 1101
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343 → 388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466 → 517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:1004 → 1050
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390 → 435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:947 → 1003
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1081 → 1131
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247 → 330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4466 → 4570
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3288 → 3590
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4615 → 4666
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4672 → 4756
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1699 → 1782
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3189 → 3275
    PKK; Polo kinase kinase
    cd19171
    Location:4818 → 4970
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1661 → 1712
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  18. XM_006535685.4 → XP_006535748.1  histone-lysine N-methyltransferase 2C isoform X4

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1880 → 2370
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1079 → 1101
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343 → 388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466 → 517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:1004 → 1050
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390 → 435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:947 → 1003
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1081 → 1131
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247 → 330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4466 → 4570
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3288 → 3590
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4615 → 4666
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4672 → 4756
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1699 → 1782
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3189 → 3275
    PKK; Polo kinase kinase
    cd19171
    Location:4822 → 4974
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1661 → 1712
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  19. XM_006535693.4 → XP_006535756.1  histone-lysine N-methyltransferase 2C isoform X14

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1880 → 2370
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1079 → 1101
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343 → 388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466 → 517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:1004 → 1050
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390 → 435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:947 → 1003
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1081 → 1131
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247 → 330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4443 → 4547
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3288 → 3590
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4592 → 4643
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4649 → 4733
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1699 → 1782
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3189 → 3275
    PKK; Polo kinase kinase
    cd19171
    Location:4795 → 4947
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1661 → 1712
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  20. XM_006535692.4 → XP_006535755.1  histone-lysine N-methyltransferase 2C isoform X12

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1880 → 2370
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1079 → 1101
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343 → 388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466 → 517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:1004 → 1050
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390 → 435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:947 → 1003
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1081 → 1131
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247 → 330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4443 → 4547
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3288 → 3590
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4592 → 4643
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4649 → 4733
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1699 → 1782
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3189 → 3275
    PKK; Polo kinase kinase
    cd19171
    Location:4799 → 4951
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1661 → 1712
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  21. XM_017320822.2 → XP_017176311.1  histone-lysine N-methyltransferase 2C isoform X9

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1880 → 2370
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1079 → 1101
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343 → 388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466 → 517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:1004 → 1050
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390 → 435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:947 → 1003
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1081 → 1131
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247 → 330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4466 → 4570
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3288 → 3590
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4615 → 4666
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4672 → 4756
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1699 → 1782
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3189 → 3275
    PKK; Polo kinase kinase
    cd19171
    Location:4818 → 4970
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1661 → 1712
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  22. XM_006535686.4 → XP_006535749.1  histone-lysine N-methyltransferase 2C isoform X5

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1880 → 2370
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1079 → 1101
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343 → 388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466 → 517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:1004 → 1050
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390 → 435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:947 → 1003
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1081 → 1131
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247 → 330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4466 → 4570
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3288 → 3590
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4615 → 4666
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4672 → 4756
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1699 → 1782
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3189 → 3275
    PKK; Polo kinase kinase
    cd19171
    Location:4822 → 4974
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1661 → 1712
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  23. XM_006535688.4 → XP_006535751.1  histone-lysine N-methyltransferase 2C isoform X7

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1880 → 2370
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1079 → 1101
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343 → 388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466 → 517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:1004 → 1050
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390 → 435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:947 → 1003
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1081 → 1131
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247 → 330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4467 → 4571
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3288 → 3590
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4616 → 4667
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4673 → 4757
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1699 → 1782
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3189 → 3275
    PKK; Polo kinase kinase
    cd19171
    Location:4819 → 4971
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1661 → 1712
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  24. XM_017320820.3 → XP_017176309.1  histone-lysine N-methyltransferase 2C isoform X6

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1878 → 2368
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1077 → 1099
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:342 → 387
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:465 → 516
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:1002 → 1048
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:389 → 434
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:945 → 1001
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1079 → 1129
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:246 → 329
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4465 → 4569
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3286 → 3588
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4614 → 4665
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4671 → 4755
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1697 → 1780
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3187 → 3273
    PKK; Polo kinase kinase
    cd19171
    Location:4821 → 4973
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1659 → 1710
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  25. XM_030254375.2 → XP_030110235.1  histone-lysine N-methyltransferase 2C isoform X16

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1839 → 2329
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1038 → 1060
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:342 → 387
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:465 → 516
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:963 → 1009
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:389 → 434
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:906 → 962
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1040 → 1090
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:246 → 329
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4426 → 4530
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3247 → 3549
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4575 → 4626
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4632 → 4716
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1658 → 1741
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3148 → 3234
    PKK; Polo kinase kinase
    cd19171
    Location:4782 → 4934
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1620 → 1671
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  26. XM_006535690.5 → XP_006535753.1  histone-lysine N-methyltransferase 2C isoform X11

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1863 → 2353
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1078 → 1100
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:342 → 387
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:465 → 516
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:1003 → 1049
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:389 → 434
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:946 → 1002
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1080 → 1130
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:246 → 329
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4450 → 4554
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3271 → 3573
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4599 → 4650
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4656 → 4740
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1682 → 1765
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3172 → 3258
    PKK; Polo kinase kinase
    cd19171
    Location:4806 → 4958
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1644 → 1695
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  27. XM_006535683.5 → XP_006535746.1  histone-lysine N-methyltransferase 2C isoform X2

    UniProtKB/Swiss-Prot
    Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
    Conserved Domains (17) summary
    PHA03247
    Location:1879 → 2369
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1078 → 1100
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:342 → 387
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:465 → 516
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:1003 → 1049
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:389 → 434
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:946 → 1002
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1080 → 1130
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:246 → 329
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:4466 → 4570
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam03154
    Location:3287 → 3589
    Atrophin-1; Atrophin-1 family
    pfam05964
    Location:4615 → 4666
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4672 → 4756
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:1698 → 1781
    Tma16; Translation machinery-associated protein 16
    pfam12474
    Location:3188 → 3274
    PKK; Polo kinase kinase
    cd19171
    Location:4822 → 4974
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    cl00082
    Location:1660 → 1711
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  28. XM_036165011.1 → XP_036020904.1  histone-lysine N-methyltransferase 2C isoform X26

    Conserved Domains (7) summary
    smart00398
    Location:154 → 207
    HMG; high mobility group
    PHA03247
    Location:375 → 865
    PHA03247; large tegument protein UL36; Provisional
    cd15697
    Location:2962 → 3066
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd19171
    Location:3318 → 3470
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    pfam05964
    Location:3111 → 3162
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:3168 → 3252
    FYRC; F/Y rich C-terminus
    pfam13868
    Location:1682 → 1769
    TPH; Trichohyalin-plectin-homology domain

  29. XM_036165010.1 → XP_036020903.1  histone-lysine N-methyltransferase 2C isoform X26

    Conserved Domains (7) summary
    smart00398
    Location:154 → 207
    HMG; high mobility group
    PHA03247
    Location:375 → 865
    PHA03247; large tegument protein UL36; Provisional
    cd15697
    Location:2962 → 3066
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd19171
    Location:3318 → 3470
    SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
    pfam05964
    Location:3111 → 3162
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:3168 → 3252
    FYRC; F/Y rich C-terminus
    pfam13868
    Location:1682 → 1769
    TPH; Trichohyalin-plectin-homology domain

  30. XM_006535703.3 → XP_006535766.1  histone-lysine N-methyltransferase 2C isoform X27

    Conserved Domains (11) summary
    PHA03247
    Location:1880 → 2370
    PHA03247; large tegument protein UL36; Provisional
    sd00025
    Location:1079 → 1101
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343 → 388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466 → 517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:1004 → 1050
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390 → 435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:1081 → 1131
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247 → 330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam11176
    Location:1699 → 1782
    Tma16; Translation machinery-associated protein 16
    cl00082
    Location:1661 → 1712
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cl22851
    Location:947 → 1003
    PHD_SF; PHD finger superfamily

RNA

  1. XR_003955625.1 RNA Sequence

  2. XR_001784670.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177283.2: Suppressed sequence

    Description
    NM_177283.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BRH4.2 GenPept UniProtKB/Swiss-Prot:Q8BRH4

Gene LinkOut

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