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TAB2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 [ Homo sapiens (human) ]

Gene ID: 23118, updated on 5-Mar-2024

Summary

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Official Symbol
TAB2provided by HGNC
Official Full Name
TGF-beta activated kinase 1 (MAP3K7) binding protein 2provided by HGNC
Primary source
HGNC:HGNC:17075
See related
Ensembl:ENSG00000055208 MIM:605101; AllianceGenome:HGNC:17075
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHTD2; TAB-2; MAP3K7IP2
Summary
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression
Ubiquitous expression in thyroid (RPKM 17.2), esophagus (RPKM 14.8) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
6q25.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (149217926..149411607)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (150417736..150611453)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (149539062..149732743)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25246 Neighboring gene Sharpr-MPRA regulatory region 12512 Neighboring gene small nuclear ribonucleoprotein polypeptide B2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17656 Neighboring gene uncharacterized LOC124901426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25247 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25249 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25250 Neighboring gene MPRA-validated peak6208 silencer Neighboring gene MPRA-validated peak6209 silencer Neighboring gene TAB2 antisense RNA 1 Neighboring gene MPRA-validated peak6210 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25251 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17657 Neighboring gene RNA, 7SL, cytoplasmic 234, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17658 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17659 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17660 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25252 Neighboring gene MPRA-validated peak6211 silencer Neighboring gene fatty acid binding protein 12 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25254 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:149699707-149700906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149746425-149746924 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:149753111-149753397 Neighboring gene small ubiquitin like modifier 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149761776-149762690 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:149772303-149772854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149772855-149773406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25255 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25256 Neighboring gene zinc finger CCCH-type containing 12D Neighboring gene ReSE screen-validated silencer GRCh37_chr6:149794343-149794528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149802875-149803730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149805477-149806341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25260 Neighboring gene coiled-coil domain containing 59 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Sacral abnormalities including caudal appendage, skeletal dysplasia, and prenatal cardiomyopathy associated with a pathogenic TAB2 variant in a 3-generation family. Koene S, et al. Am J Med Genet A, 2022 Dec. PMID 36000780, Free PMC Article
  2. TAB2 Promotes the Biological Functions of Head and Neck Squamous Cell Carcinoma Cells via EMT and PI3K Pathway. Liu H, et al. Dis Markers, 2022. PMID 35978886, Free PMC Article
  3. Expanding the phenotype of TAB2 variants and literature review. Woods E, et al. Am J Med Genet A, 2022 Nov. PMID 35971781, Free PMC Article
  4. [Association Between TAB2 Gene Polymorphisms and Susceptibility to Cryptorchidism in Han Chinese Population in Southwest China]. Su M, et al. Sichuan Da Xue Xue Bao Yi Xue Ban, 2022 Jul. PMID 35871735, Free PMC Article
  5. There is more to it than just congenital heart defects - The phenotypic spectrum of TAB2-related syndrome. Westphal DS, et al. Gene, 2022 Mar 10. PMID 34995729

See all (231) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sacral abnormalities including caudal appendage, skeletal dysplasia, and prenatal cardiomyopathy associated with a pathogenic TAB2 variant in a 3-generation family.
    Title: Sacral abnormalities including caudal appendage, skeletal dysplasia, and prenatal cardiomyopathy associated with a pathogenic TAB2 variant in a 3-generation family.
  2. Expanding the phenotype of TAB2 variants and literature review.
    Title: Expanding the phenotype of TAB2 variants and literature review.
  3. TAB2 Promotes the Biological Functions of Head and Neck Squamous Cell Carcinoma Cells via EMT and PI3K Pathway.
    Title: TAB2 Promotes the Biological Functions of Head and Neck Squamous Cell Carcinoma Cells via EMT and PI3K Pathway.
  4. [Association Between TAB2 Gene Polymorphisms and Susceptibility to Cryptorchidism in Han Chinese Population in Southwest China].
    Title: [Association Between TAB2 Gene Polymorphisms and Susceptibility to Cryptorchidism in Han Chinese Population in Southwest China].
  5. TAB2 variants cause cardiovascular heart disease, connective tissue disorder, and developmental delay.
    Title: TAB2 variants cause cardiovascular heart disease, connective tissue disorder, and developmental delay.
  6. TAB2 deletions and variants cause a highly recognisable syndrome with mitral valve disease, cardiomyopathy, short stature and hypermobility.
    Title: TAB2 deletions and variants cause a highly recognisable syndrome with mitral valve disease, cardiomyopathy, short stature and hypermobility.
  7. Loss-of-function variants in exon 4 of TAB2 cause a recognizable multisystem disorder with cardiovascular, facial, cutaneous, and musculoskeletal involvement.
    Title: Loss-of-function variants in exon 4 of TAB2 cause a recognizable multisystem disorder with cardiovascular, facial, cutaneous, and musculoskeletal involvement.
  8. Circular RNA WHSC1 exerts oncogenic properties by regulating miR-7/TAB2 in lung cancer.
    Title: Circular RNA WHSC1 exerts oncogenic properties by regulating miR-7/TAB2 in lung cancer.
  9. There is more to it than just congenital heart defects - The phenotypic spectrum of TAB2-related syndrome.
    Title: There is more to it than just congenital heart defects - The phenotypic spectrum of TAB2-related syndrome.
  10. Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population.
    Title: Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population.
Submit: New GeneRIF Correction See all GeneRIFs (54)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Congenital heart defects, multiple types, 2
MedGen: C3554279 OMIM: 614980 GeneReviews: Not available
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Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2020-05-27)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated 2020-05-27)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study.
EBI GWAS Catalog
Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer.
EBI GWAS Catalog
Genome-wide meta-analysis for severe diabetic retinopathy.
EBI GWAS Catalog
Wnt signaling and Dupuytren's disease.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2; MAP3K7IP2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Tat tat Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of TAB-2 PubMed
capsid gag The TAK1 kinase complex (TAK1/TAB2/TAB3) contributes to capsid-specific restriction mediated by TRIM5alpha. TRIM5alpha activates TAK1 autophosphorylation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21885, KIAA0733, DKFZp781G0741

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of autophagy TAS
Traceable Author Statement
more info
 PubMed 
involved_in non-canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endosome membrane TAS
Traceable Author Statement
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
Names
TAK1-binding protein 2
mitogen-activated protein kinase kinase kinase 7-interacting protein 2

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021386.2 RefSeqGene

    Range
    104789..198684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001292034.3 → NP_001278963.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform a

    See identical proteins and their annotated locations for NP_001278963.1

    Status: REVIEWED

    Source sequence(s)
    AB018276, AL138727, BC035910
    Consensus CDS
    CCDS5214.1
    UniProtKB/Swiss-Prot
    B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7
    Related
    ENSP00000490618.1, ENST00000637181.2
    Conserved Domains (4) summary
    smart00547
    Location:667 → 690
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:9 → 50
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    TIGR04523
    Location:537 → 614
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    sd00029
    Location:668 → 687
    zf-RanBP2; RanBP2-type Zn finger [structural motif]

  2. NM_001292035.3 → NP_001278964.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform b

    See identical proteins and their annotated locations for NP_001278964.1

    Status: REVIEWED

    Source sequence(s)
    AK295750, BC035910, BX645362
    UniProtKB/TrEMBL
    B4DIR9
    Conserved Domains (3) summary
    smart00547
    Location:635 → 658
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:636 → 655
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cl00087
    Location:502 → 570
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

  3. NM_001369506.1 → NP_001356435.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL031133, AL138727, AL139103
    Consensus CDS
    CCDS5214.1
    UniProtKB/Swiss-Prot
    B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7
    Conserved Domains (4) summary
    smart00547
    Location:667 → 690
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:9 → 50
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    TIGR04523
    Location:537 → 614
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    sd00029
    Location:668 → 687
    zf-RanBP2; RanBP2-type Zn finger [structural motif]

  4. NM_015093.6 → NP_055908.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform a

    See identical proteins and their annotated locations for NP_055908.1

    Status: REVIEWED

    Source sequence(s)
    AK307650, AK315038, BC035910
    Consensus CDS
    CCDS5214.1
    UniProtKB/Swiss-Prot
    B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7
    Conserved Domains (4) summary
    smart00547
    Location:667 → 690
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:9 → 50
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    TIGR04523
    Location:537 → 614
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    sd00029
    Location:668 → 687
    zf-RanBP2; RanBP2-type Zn finger [structural motif]

RNA

  1. NR_125861.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AI159838, BX645362, DB467477

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    149217926..149411607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535633.3 → XP_011533935.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011533935.1

    UniProtKB/Swiss-Prot
    B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7
    Related
    ENSP00000356426.1, ENST00000367456.5
    Conserved Domains (4) summary
    smart00547
    Location:667 → 690
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:9 → 50
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    TIGR04523
    Location:537 → 614
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    sd00029
    Location:668 → 687
    zf-RanBP2; RanBP2-type Zn finger [structural motif]

  2. XM_047418487.1 → XP_047274443.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

  3. XM_047418489.1 → XP_047274445.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

  4. XM_047418486.1 → XP_047274442.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

  5. XM_047418488.1 → XP_047274444.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

  6. XM_017010592.3 → XP_016866081.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7
    Conserved Domains (4) summary
    smart00547
    Location:667 → 690
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:9 → 50
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    TIGR04523
    Location:537 → 614
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    sd00029
    Location:668 → 687
    zf-RanBP2; RanBP2-type Zn finger [structural motif]

  7. XM_047418485.1 → XP_047274441.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

  8. XM_047418490.1 → XP_047274446.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    150417736..150611453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354841.1 → XP_054210816.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

  2. XM_054354843.1 → XP_054210818.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

  3. XM_054354840.1 → XP_054210815.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

  4. XM_054354842.1 → XP_054210817.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

  5. XM_054354845.1 → XP_054210820.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

  6. XM_054354844.1 → XP_054210819.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

  7. XM_054354839.1 → XP_054210814.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9NYJ8, Q9UFP7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145342.1: Suppressed sequence

    Description
    NM_145342.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NYJ8.1 GenPept UniProtKB/Swiss-Prot:Q9NYJ8

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