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FLT1 fms related receptor tyrosine kinase 1 [ Homo sapiens (human) ]

Gene ID: 2321, updated on 11-Apr-2024

Summary

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Official Symbol
FLT1provided by HGNC
Official Full Name
fms related receptor tyrosine kinase 1provided by HGNC
Primary source
HGNC:HGNC:3763
See related
Ensembl:ENSG00000102755 MIM:165070; AllianceGenome:HGNC:3763
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FLT; FLT-1; VEGFR1; VEGFR-1
Summary
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]
Expression
Biased expression in placenta (RPKM 90.6), thyroid (RPKM 20.1) and 8 other tissues See more
Orthologs
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Genomic context

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See FLT1 in Genome Data Viewer
Location:
13q12.3
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (28300346..28495128, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (27522576..27717351, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (28874483..29069265, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene poly(A) specific ribonuclease subunit PAN3 Neighboring gene NANOG hESC enhancer GRCh37_chr13:28812056-28812711 Neighboring gene RNA, U6 small nuclear 82, pseudogene Neighboring gene uncharacterized LOC124903140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:28863191-28863692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:28863693-28864192 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:28870451-28870609 Neighboring gene uncharacterized LOC124903141 Neighboring gene Sharpr-MPRA regulatory region 10890 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:28896366-28897565 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:28902230-28902730 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7511 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7513 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7514 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:29004443-29005102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:29010702-29011644 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:29012644-29013428 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:29014214-29014998 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32819 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:29041404-29041635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5212 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5213 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:29078159-29078659 Neighboring gene Sharpr-MPRA regulatory region 5274 Neighboring gene Sharpr-MPRA regulatory region 7947 Neighboring gene uncharacterized LOC124903142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5215 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7516 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:29148510-29149709 Neighboring gene uncharacterized LOC105370135 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:29157670-29158170

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Vascular endothelial growth factor receptor 1 gene (FLT1) longevity variant increases lifespan by reducing mortality risk posed by hypertension. Morris BJ, et al. Aging (Albany NY), 2023 May 12. PMID 37178326, Free PMC Article
  2. The Soluble Fms-like Tyrosine Kinase-1 Contributes to Structural and Functional Changes in Endothelial Cells in Chronic Kidney Disease. Schulz A, et al. Int J Mol Sci, 2022 Dec 16. PMID 36555698, Free PMC Article
  3. sFlt-1 in Chronic Kidney Disease: Friend or Foe? Matsui M, et al. Int J Mol Sci, 2022 Nov 16. PMID 36430665, Free PMC Article
  4. Soluble FMS-Like Tyrosine Kinase-1: Role in placenta accreta spectrum disorder. Lumbanraja S, et al. F1000Res, 2021. PMID 36127888, Free PMC Article
  5. Systemic Maternal Human sFLT1 Overexpression Leads to an Impaired Foetal Brain Development of Growth-Restricted Foetuses upon Experimental Preeclampsia. Vogtmann R, et al. Oxid Med Cell Longev, 2022. PMID 35693702, Free PMC Article

See all (812) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gasdermin D regulates soluble fms-like tyrosine kinase 1 release in macrophages.
    Title: Gasdermin D regulates soluble fms-like tyrosine kinase 1 release in macrophages.
  2. Overexpression of Human sFLT1 in the Spongiotrophoblast Is Sufficient to Induce Placental Dysfunction and Fetal Growth Restriction in Transgenic Mice.
    Title: Overexpression of Human sFLT1 in the Spongiotrophoblast Is Sufficient to Induce Placental Dysfunction and Fetal Growth Restriction in Transgenic Mice.
  3. A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells.
    Title: A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells.
  4. Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells.
    Title: Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells.
  5. Persistently elevated sFlt-1 and recovery of reduced ADAMTS13 activity in malignant hypertension.
    Title: Persistently elevated sFlt-1 and recovery of reduced ADAMTS13 activity in malignant hypertension.
  6. Preeclamptic serum and soluble fms-like tyrosine kinase-1 suppress endothelial inward rectifier potassium currents.
    Title: Preeclamptic serum and soluble fms-like tyrosine kinase-1 suppress endothelial inward rectifier potassium currents.
  7. SOD3 regulates FLT1 to affect bone metabolism by promoting osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK pathways.
    Title: SOD3 regulates FLT1 to affect bone metabolism by promoting osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK pathways.
  8. Reference Interval of Soluble FMS-like Tyrosine Kinase-1 in Non-Pregnant and Pregnant Females: A Novel Biomarker for Pre-eclampsia.
    Title: Reference Interval of Soluble FMS‑like Tyrosine Kinase‑1 in Non-Pregnant and Pregnant Females: A Novel Biomarker for Pre-eclampsia.
  9. High placental expression of FLT1, LEP, PHYHIP and IL3RA - In persons of African ancestry with severe preeclampsia.
    Title: High placental expression of FLT1, LEP, PHYHIP and IL3RA - In persons of African ancestry with severe preeclampsia.
  10. Wnt5a-Flt1 activation contributes to preterm altered cerebral angiogenesis after prenatal inflammation.
    Title: Wnt5a-Flt1 activation contributes to preterm altered cerebral angiogenesis after prenatal inflammation.
Submit: New GeneRIF Correction See all GeneRIFs (723)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of a coronary artery disease risk variant.
EBI GWAS Catalog
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates Flt-1 expression in human mesenchymal stem cells PubMed
Nef nef HIV-1 Nef upregulates FLT1 in podocytes PubMed
Tat tat HIV-1 Tat inhibits the differentiation of mesenchymal stem cells (MSCs) to endothelial cells by downregulating the expression of VEGF-induced endothelial markers such as Flt-1, KDR and vWF PubMed
tat HIV-1 Tat-mediated inhibition of autophagy in bystander macrophages/monocytic cells requires CXCR4, VEGFR1, and beta-integrins PubMed
tat The mechanism of monocyte activation by HIV-1 Tat involves the binding of Tat to VEGFR-1/Flt-1 and activating signals through this receptor PubMed
tat The soluble form of VEGFR-1 inhibits monocyte polarization and migration induced by HIV-1 Tat PubMed
tat The biologic activities of HIV-1 Tat in human monocytes are, at least in part, elicited by Tat activation of VEGFR-1/Flt-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables growth factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables placental growth factor receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables vascular endothelial growth factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables vascular endothelial growth factor receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables vascular endothelial growth factor receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in blood vessel morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in cellular response to vascular endothelial growth factor stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in embryonic morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in hyaloid vascular plexus regression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in monocyte chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of vascular endothelial cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell population proliferation TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of phospholipase C activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vascular endothelial growth factor receptor-1 signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vascular endothelial growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space TAS
Traceable Author Statement
more info
 PubMed 
located_in focal adhesion HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
vascular endothelial growth factor receptor 1
Names
fms related tyrosine kinase 1
fms-like tyrosine kinase 1
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
tyrosine-protein kinase FRT
tyrosine-protein kinase receptor FLT
vascular permeability factor receptor
NP_001153392.1
NP_001153502.1
NP_001153503.1
NP_002010.2

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012003.1 RefSeqGene

    Range
    5001..199783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_425

mRNA and Protein(s)

  1. NM_001159920.2 → NP_001153392.1  vascular endothelial growth factor receptor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001153392.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as sFlt1 or sVEGFR-1, differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded soluble protein (isoform 2) has a shorter, distinct C-terminus and lacks the transmembrane and cytoplasmic regions of isoform 1.
    Source sequence(s)
    AL138712, AL139005
    Consensus CDS
    CCDS73556.1
    UniProtKB/TrEMBL
    A0A1W2PNW4
    Related
    ENSP00000484039.1, ENST00000615840.5
    Conserved Domains (5) summary
    cd07702
    Location:353 → 424
    Ig_VEGFR-1; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
    smart00409
    Location:143 → 219
    IG; Immunoglobulin
    smart00410
    Location:568 → 640
    IG_like; Immunoglobulin like
    pfam13927
    Location:427 → 539
    Ig_3; Immunoglobulin domain
    cl11960
    Location:245 → 327
    Ig; Immunoglobulin domain

  2. NM_001160030.2 → NP_001153502.1  vascular endothelial growth factor receptor 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001153502.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded soluble protein (isoform 3) has a shorter, distinct C-terminus and lacks the transmembrane and cytoplasmic regions of isoform 1.
    Source sequence(s)
    AK300392, AL138712, EU360600, EU368830
    Consensus CDS
    CCDS53860.1
    UniProtKB/TrEMBL
    A0A1W2PNW4
    Related
    ENSP00000437631.1, ENST00000541932.5
    Conserved Domains (5) summary
    smart00410
    Location:568 → 640
    IG_like; Immunoglobulin like
    cd00096
    Location:248 → 252
    Ig; Ig strand B [structural motif]
    cd07702
    Location:333 → 424
    IgI_VEGFR-1; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1); member of the I-set of Ig superfamily (IgSF) domains
    pfam13927
    Location:427 → 539
    Ig_3; Immunoglobulin domain
    cl11960
    Location:230 → 330
    Ig; Immunoglobulin domain

  3. NM_001160031.1 → NP_001153503.1  vascular endothelial growth factor receptor 1 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001153503.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded soluble protein (isoform 4) has a shorter, distinct C-terminus and lacks the transmembrane and cytoplasmic regions of isoform 1.
    Source sequence(s)
    DA844548, EU826561
    Consensus CDS
    CCDS53861.1
    UniProtKB/Swiss-Prot
    P17948
    Related
    ENSP00000442630.1, ENST00000539099.2
    Conserved Domains (4) summary
    cd05742
    Location:245 → 327
    Ig1_VEGFR_like; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins
    cd07702
    Location:353 → 424
    Ig2_VEGFR-1; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
    smart00410
    Location:237 → 328
    IG_like; Immunoglobulin like
    cl11960
    Location:439 → 466
    Ig; Immunoglobulin domain

  4. NM_002019.4 → NP_002010.2  vascular endothelial growth factor receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_002010.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) the longest isoform (1). Isoform 1 is a transmembrane protein.
    Source sequence(s)
    AF063657, AL138712, BU151621, BX504049, DA851664
    Consensus CDS
    CCDS9330.1
    UniProtKB/Swiss-Prot
    A3E342, A3E344, A8KA71, B0LPF1, B2BF46, B2BF47, B2BF48, B3FR89, B5A923, F5H5L6, O60722, P16057, P17948, Q12954
    UniProtKB/TrEMBL
    L7RSL3
    Related
    ENSP00000282397.4, ENST00000282397.9
    Conserved Domains (8) summary
    cd05742
    Location:245 → 327
    Ig1_VEGFR_like; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins
    cd07702
    Location:353 → 424
    Ig2_VEGFR-1; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
    smart00408
    Location:676 → 738
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:568 → 640
    IG; Immunoglobulin
    smart00410
    Location:237 → 328
    IG_like; Immunoglobulin like
    pfam07679
    Location:661 → 748
    I-set; Immunoglobulin I-set domain
    cd14207
    Location:819 → 1157
    PTKc_VEGFR1; Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors
    pfam07714
    Location:827 → 1154
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    28300346..28495128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    27522576..27717351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17948.2 GenPept UniProtKB/Swiss-Prot:P17948

Gene LinkOut

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