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ADGRL3 adhesion G protein-coupled receptor L3 [ Homo sapiens (human) ]

Gene ID: 23284, updated on 11-Apr-2024

Summary

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Official Symbol
ADGRL3provided by HGNC
Official Full Name
adhesion G protein-coupled receptor L3provided by HGNC
Primary source
HGNC:HGNC:20974
See related
Ensembl:ENSG00000150471 MIM:616417; AllianceGenome:HGNC:20974
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CL3; LEC3; CIRL3; LPHN3
Summary
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 7.2), adrenal (RPKM 1.9) and 13 other tissues See more
Orthologs
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Genomic context

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See ADGRL3 in Genome Data Viewer
Location:
4q13.1
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (61200326..62078335)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (64638264..65515643)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (62066044..62944053)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:61799272-61800471 Neighboring gene microRNA 548ag-1 Neighboring gene Sharpr-MPRA regulatory region 1933 Neighboring gene long intergenic non-protein coding RNA 2271 Neighboring gene uncharacterized LOC124900173 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:62068190-62068762 Neighboring gene ribosomal protein L17 pseudogene 19 Neighboring gene Sharpr-MPRA regulatory region 909 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:62252700-62253638 Neighboring gene Sharpr-MPRA regulatory region 11493 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:62459979-62460480 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:62512707-62513321 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:62512092-62512706 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:62629970-62630560 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:62630561-62631150 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:62633919-62634780 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:62634781-62635644 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:62635645-62636506 Neighboring gene ribosomal protein S12 pseudogene 9 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:62776506-62777086 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:62777087-62777665 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:62857945-62858479 Neighboring gene ADGRL3 antisense RNA 1 Neighboring gene uncharacterized LOC101927145 Neighboring gene ribosomal protein S15a pseudogene 17 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:63071027-63071527

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to the incretin polypeptide GIP. Vidal OM, et al. Sci Rep, 2022 Sep 23. PMID 36151371, Free PMC Article
  2. Thwarting of Lphn3 Functions in Cell Motility and Signaling by Cancer-Related GAIN Domain Somatic Mutations. Avila-Zozaya M, et al. Cells, 2022 Jun 13. PMID 35741042, Free PMC Article
  3. Convergent selective signaling impairment exposes the pathogenicity of latrophilin-3 missense variants linked to inheritable ADHD susceptibility. Moreno-Salinas AL, et al. Mol Psychiatry, 2022 May. PMID 35393556, Free PMC Article
  4. Driver mutations in ADGRL3 are involved in the evolution of ependymoma. Wang J, et al. Lab Invest, 2022 Jul. PMID 35013530
  5. Adhesion G protein-coupled receptor L3 gene variants: Statistically significant association observed in the male Indo-caucasoid Attention deficit hyperactivity disorder probands. Chatterjee M, et al. Mol Biol Rep, 2021 Apr. PMID 33914279

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms.
    Title: The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms.
  2. ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to the incretin polypeptide GIP.
    Title: ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to the incretin polypeptide GIP.
  3. Driver mutations in ADGRL3 are involved in the evolution of ependymoma.
    Title: Driver mutations in ADGRL3 are involved in the evolution of ependymoma.
  4. Thwarting of Lphn3 Functions in Cell Motility and Signaling by Cancer-Related GAIN Domain Somatic Mutations.
    Title: Thwarting of Lphn3 Functions in Cell Motility and Signaling by Cancer-Related GAIN Domain Somatic Mutations.
  5. Convergent selective signaling impairment exposes the pathogenicity of latrophilin-3 missense variants linked to inheritable ADHD susceptibility.
    Title: Convergent selective signaling impairment exposes the pathogenicity of latrophilin-3 missense variants linked to inheritable ADHD susceptibility.
  6. Machine Learning Prediction of ADHD Severity: Association and Linkage to ADGRL3, DRD4, and SNAP25.
    Title: Machine Learning Prediction of ADHD Severity: Association and Linkage to ADGRL3, DRD4, and SNAP25.
  7. Adhesion G protein-coupled receptor L3 gene variants: Statistically significant association observed in the male Indo-caucasoid Attention deficit hyperactivity disorder probands.
    Title: Adhesion G protein-coupled receptor L3 gene variants: Statistically significant association observed in the male Indo-caucasoid Attention deficit hyperactivity disorder probands.
  8. CDH13 and LPHN3 Gene Polymorphisms in Attention-Deficit/Hyperactivity Disorder: Their Relation to Clinical Characteristics.
    Title: CDH13 and LPHN3 Gene Polymorphisms in Attention-Deficit/Hyperactivity Disorder: Their Relation to Clinical Characteristics.
  9. Brain structural and functional substrates of ADGRL3 (latrophilin 3) haplotype in attention-deficit/hyperactivity disorder.
    Title: Brain structural and functional substrates of ADGRL3 (latrophilin 3) haplotype in attention-deficit/hyperactivity disorder.
  10. Expression of the adult ADHD-associated gene ADGRL3 is dysregulated by risk variants and environmental risk factors.
    Title: Expression of the adult ADHD-associated gene ADGRL3 is dysregulated by risk variants and environmental risk factors.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.
EBI GWAS Catalog
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion via plasma-membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion via plasma-membrane adhesion molecules IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adhesion G protein-coupled receptor L3
Names
calcium-independent alpha-latrotoxin receptor 3
latrophilin homolog 3 (cow)
latrophilin-3
lectomedin 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033950.2 RefSeqGene

    Range
    4071..882080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322246.3 → NP_001309175.1  adhesion G protein-coupled receptor L3 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    Consensus CDS
    CCDS82926.1
    UniProtKB/TrEMBL
    E7EMR3
    Related
    ENSP00000423388.1, ENST00000512091.6
    Conserved Domains (8) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:814 → 866
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:495 → 559
    HormR; Domain present in hormone receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1140 → 1203
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:567 → 788
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:876 → 901
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:874 → 1140
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. NM_001322402.3 → NP_001309331.1  adhesion G protein-coupled receptor L3 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E7ETE3
    Conserved Domains (8) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882 → 934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    COG0531
    Location:952 → 1179
    PotE; Amino acid transporter [Amino acid transport and metabolism]
    pfam00002
    Location:942 → 1187
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1208 → 1537
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:636 → 854
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  3. NM_001371342.1 → NP_001358271.1  adhesion G protein-coupled receptor L3 isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E9PBG4
    Conserved Domains (7) summary
    smart00284
    Location:132 → 388
    OLF; Olfactomedin-like domains
    smart00303
    Location:796 → 848
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    cd16005
    Location:856 → 1113
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1113 → 1442
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:563 → 770
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  4. NM_001371343.2 → NP_001358272.1  adhesion G protein-coupled receptor L3 isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E7ETE3
    Conserved Domains (7) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:864 → 916
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:558 → 622
    HormR; Domain present in hormone receptors
    cd16005
    Location:924 → 1181
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1181 → 1510
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:630 → 838
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  5. NM_001371344.2 → NP_001358273.1  adhesion G protein-coupled receptor L3 isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    Consensus CDS
    CCDS93541.1
    UniProtKB/TrEMBL
    E7ETE3, E7EVD6
    Related
    ENSP00000421372.1, ENST00000507625.5
    Conserved Domains (7) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882 → 934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    cd16005
    Location:942 → 1199
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1199 → 1528
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:635 → 856
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  6. NM_001371345.2 → NP_001358274.1  adhesion G protein-coupled receptor L3 isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E7ETE3
    Conserved Domains (7) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:869 → 921
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    cd16005
    Location:929 → 1186
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1186 → 1515
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:636 → 843
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  7. NM_001371346.2 → NP_001358275.1  adhesion G protein-coupled receptor L3 isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E9PBG4
    Conserved Domains (7) summary
    smart00284
    Location:132 → 388
    OLF; Olfactomedin-like domains
    smart00303
    Location:809 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    cd16005
    Location:869 → 1126
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:1126 → 1455
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:563 → 783
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd22846
    Location:29 → 126
    Gal_Rha_Lectin_LPHN3; galactose/rhamnose binding lectin domain found in latrophilin-3 and similar proteins

  8. NM_001387522.1 → NP_001374451.1  adhesion G protein-coupled receptor L3 isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    Consensus CDS
    CCDS93541.1
    UniProtKB/TrEMBL
    E7ETE3, E7EVD6
    Conserved Domains (7) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882 → 934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    cd16005
    Location:942 → 1199
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1199 → 1528
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:635 → 856
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  9. NM_001387523.1 → NP_001374452.1  adhesion G protein-coupled receptor L3 isoform 9 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E7ETE3
    Conserved Domains (7) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:864 → 916
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:558 → 622
    HormR; Domain present in hormone receptors
    cd16005
    Location:924 → 1190
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1190 → 1519
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:630 → 838
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  10. NM_001387524.1 → NP_001374453.1  adhesion G protein-coupled receptor L3 isoform 25 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E7ETE3
    Conserved Domains (7) summary
    smart00284
    Location:200 → 456
    OLF; Olfactomedin-like domains
    smart00303
    Location:864 → 916
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:558 → 622
    HormR; Domain present in hormone receptors
    cd16005
    Location:924 → 1181
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1181 → 1510
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:630 → 838
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  11. NM_001387525.1 → NP_001374454.1  adhesion G protein-coupled receptor L3 isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E7ETE3
    Conserved Domains (7) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:864 → 916
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:558 → 622
    HormR; Domain present in hormone receptors
    cd16005
    Location:924 → 1181
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1181 → 1510
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:630 → 838
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  12. NM_001387526.1 → NP_001374455.1  adhesion G protein-coupled receptor L3 isoform 10 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E7EW95
    Related
    ENSP00000421627.1, ENST00000508946.5
    Conserved Domains (7) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:809 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    cd16005
    Location:869 → 1135
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1135 → 1507
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 783
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  13. NM_001387527.1 → NP_001374456.1  adhesion G protein-coupled receptor L3 isoform 11 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E9PBG4
    Conserved Domains (7) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:809 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    cd16005
    Location:869 → 1126
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1126 → 1504
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 783
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  14. NM_001387528.1 → NP_001374457.1  adhesion G protein-coupled receptor L3 isoform 26 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E7EW95
    Conserved Domains (7) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:814 → 866
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:495 → 559
    HormR; Domain present in hormone receptors
    cd16005
    Location:874 → 1140
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1140 → 1475
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:567 → 788
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  15. NM_001387529.1 → NP_001374458.1  adhesion G protein-coupled receptor L3 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    Consensus CDS
    CCDS54768.1
    UniProtKB/TrEMBL
    E7EW95
    Conserved Domains (7) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:814 → 866
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:495 → 559
    HormR; Domain present in hormone receptors
    cd16005
    Location:874 → 1140
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1140 → 1469
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:567 → 788
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  16. NM_001387530.1 → NP_001374459.1  adhesion G protein-coupled receptor L3 isoform 12 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E7EW95
    Conserved Domains (7) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:809 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    cd16005
    Location:869 → 1135
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1135 → 1464
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 783
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  17. NM_001387531.1 → NP_001374460.1  adhesion G protein-coupled receptor L3 isoform 12 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E7EW95
    Conserved Domains (7) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:809 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    cd16005
    Location:869 → 1135
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1135 → 1464
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 783
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  18. NM_001387532.1 → NP_001374461.1  adhesion G protein-coupled receptor L3 isoform 12 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E7EW95
    Conserved Domains (7) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:809 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    cd16005
    Location:869 → 1135
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1135 → 1464
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 783
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  19. NM_001387533.1 → NP_001374462.1  adhesion G protein-coupled receptor L3 isoform 13 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E9PBG4
    Related
    ENSP00000424258.1, ENST00000514996.5
    Conserved Domains (7) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:814 → 866
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:495 → 559
    HormR; Domain present in hormone receptors
    cd16005
    Location:874 → 1131
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1131 → 1460
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:567 → 788
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  20. NM_001387534.1 → NP_001374463.1  adhesion G protein-coupled receptor L3 isoform 13 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E9PBG4
    Conserved Domains (7) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:814 → 866
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:495 → 559
    HormR; Domain present in hormone receptors
    cd16005
    Location:874 → 1131
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1131 → 1460
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:567 → 788
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  21. NM_001387535.1 → NP_001374464.1  adhesion G protein-coupled receptor L3 isoform 14 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E9PBG4
    Conserved Domains (7) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:809 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    cd16005
    Location:869 → 1126
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1126 → 1455
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 783
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  22. NM_001387536.1 → NP_001374465.1  adhesion G protein-coupled receptor L3 isoform 14 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E9PBG4
    Conserved Domains (7) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:809 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    cd16005
    Location:869 → 1126
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1126 → 1455
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 783
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  23. NM_001387537.1 → NP_001374466.1  adhesion G protein-coupled receptor L3 isoform 15 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/Swiss-Prot
    E9PE04, O94867, Q9HAR2, Q9NWK5
    UniProtKB/TrEMBL
    E9PBG4
    Conserved Domains (7) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:801 → 853
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:495 → 559
    HormR; Domain present in hormone receptors
    cd16005
    Location:861 → 1118
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1118 → 1447
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:567 → 775
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  24. NM_001387538.1 → NP_001374467.1  adhesion G protein-coupled receptor L3 isoform 15 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/Swiss-Prot
    E9PE04, O94867, Q9HAR2, Q9NWK5
    UniProtKB/TrEMBL
    E9PBG4
    Conserved Domains (7) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:801 → 853
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:495 → 559
    HormR; Domain present in hormone receptors
    cd16005
    Location:861 → 1118
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1118 → 1447
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:567 → 775
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  25. NM_001387539.1 → NP_001374468.1  adhesion G protein-coupled receptor L3 isoform 15 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/Swiss-Prot
    E9PE04, O94867, Q9HAR2, Q9NWK5
    UniProtKB/TrEMBL
    E9PBG4
    Conserved Domains (7) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:801 → 853
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:495 → 559
    HormR; Domain present in hormone receptors
    cd16005
    Location:861 → 1118
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1118 → 1447
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:567 → 775
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  26. NM_001387540.1 → NP_001374469.1  adhesion G protein-coupled receptor L3 isoform 24 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E9PBG4
    Conserved Domains (7) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:796 → 848
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    cd16005
    Location:856 → 1113
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1113 → 1442
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 770
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  27. NM_001387541.1 → NP_001374470.1  adhesion G protein-coupled receptor L3 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E9PBG4
    Conserved Domains (7) summary
    smart00284
    Location:111 → 367
    OLF; Olfactomedin-like domains
    smart00303
    Location:788 → 840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469 → 533
    HormR; Domain present in hormone receptors
    cd16005
    Location:848 → 1105
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:17 → 97
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1105 → 1434
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:541 → 762
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  28. NM_001387542.1 → NP_001374471.1  adhesion G protein-coupled receptor L3 isoform 17 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E9PBG4
    Conserved Domains (8) summary
    smart00284
    Location:132 → 388
    OLF; Olfactomedin-like domains
    smart00303
    Location:809 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1087 → 1416
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 783
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:866 → 888
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:861 → 1087
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  29. NM_001387543.1 → NP_001374472.1  adhesion G protein-coupled receptor L3 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E9PBG4
    Conserved Domains (6) summary
    smart00284
    Location:43 → 299
    OLF; Olfactomedin-like domains
    smart00303
    Location:715 → 767
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:396 → 460
    HormR; Domain present in hormone receptors
    cd16005
    Location:775 → 1032
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:1032 → 1361
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:468 → 689
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  30. NM_001387544.1 → NP_001374473.1  adhesion G protein-coupled receptor L3 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E9PBG4
    Conserved Domains (6) summary
    smart00284
    Location:43 → 299
    OLF; Olfactomedin-like domains
    smart00303
    Location:715 → 767
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:396 → 460
    HormR; Domain present in hormone receptors
    cd16005
    Location:775 → 1032
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:1032 → 1361
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:468 → 689
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  31. NM_001387545.1 → NP_001374474.1  adhesion G protein-coupled receptor L3 isoform 19 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    Consensus CDS
    CCDS93539.1
    UniProtKB/TrEMBL
    E7EN28, E7EUP0
    Conserved Domains (8) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882 → 934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1208 → 1271
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:635 → 856
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:944 → 969
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:942 → 1208
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  32. NM_001387546.1 → NP_001374475.1  adhesion G protein-coupled receptor L3 isoform 20 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E7ENK1
    Related
    ENSP00000423434.1, ENST00000504896.5
    Conserved Domains (8) summary
    smart00284
    Location:132 → 388
    OLF; Olfactomedin-like domains
    smart00303
    Location:809 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1135 → 1242
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 783
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:871 → 896
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:869 → 1135
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  33. NM_001387547.1 → NP_001374476.1  adhesion G protein-coupled receptor L3 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    Consensus CDS
    CCDS82926.1
    UniProtKB/TrEMBL
    E7EMR3
    Conserved Domains (8) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:814 → 866
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:495 → 559
    HormR; Domain present in hormone receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1140 → 1203
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:567 → 788
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:876 → 901
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:874 → 1140
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  34. NM_001387548.1 → NP_001374477.1  adhesion G protein-coupled receptor L3 isoform 21 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E7EMR3
    Conserved Domains (8) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:809 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1135 → 1198
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 783
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:871 → 896
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:869 → 1135
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  35. NM_001387549.1 → NP_001374478.1  adhesion G protein-coupled receptor L3 isoform 22 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    UniProtKB/TrEMBL
    E7EMR3
    Related
    ENSP00000424120.1, ENST00000506700.5
    Conserved Domains (8) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:809 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1126 → 1189
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 783
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:871 → 896
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:869 → 1126
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  36. NM_001387552.1 → NP_001374481.1  adhesion G protein-coupled receptor L3 isoform 23 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    Consensus CDS
    CCDS93538.1
    UniProtKB/TrEMBL
    A0A804HKL8, E7ETE3
    Related
    ENSP00000507980.1, ENST00000683033.1
    Conserved Domains (7) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882 → 934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    cd16005
    Location:942 → 1208
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1208 → 1543
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:635 → 856
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  37. NM_015236.7 → NP_056051.2  adhesion G protein-coupled receptor L3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_056051.2

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
    Consensus CDS
    CCDS54768.1
    UniProtKB/TrEMBL
    E7EW95
    Related
    ENSP00000422533.1, ENST00000514591.5
    Conserved Domains (7) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:814 → 866
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:495 → 559
    HormR; Domain present in hormone receptors
    cd16005
    Location:874 → 1140
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1140 → 1469
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:567 → 788
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    61200326..62078335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449940.1 → XP_047305896.1  adhesion G protein-coupled receptor L3 isoform X14

    Conserved Domains (7) summary
    smart00284
    Location:132 → 388
    OLF; Olfactomedin-like domains
    smart00303
    Location:809 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    cd16005
    Location:869 → 1126
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:1126 → 1455
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:563 → 783
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd22846
    Location:29 → 126
    Gal_Rha_Lectin_LPHN3; galactose/rhamnose binding lectin domain found in latrophilin-3 and similar proteins

  2. XM_047449941.1 → XP_047305897.1  adhesion G protein-coupled receptor L3 isoform X15

  3. XM_017007929.2 → XP_016863418.1  adhesion G protein-coupled receptor L3 isoform X1

    UniProtKB/TrEMBL
    E7ETE3

  4. XM_017007931.1 → XP_016863420.1  adhesion G protein-coupled receptor L3 isoform X2

    UniProtKB/TrEMBL
    E7ETE3, E7EUW2
    Related
    ENSP00000420931.1, ENST00000506720.5

  5. XM_017007940.1 → XP_016863429.1  adhesion G protein-coupled receptor L3 isoform X16

    UniProtKB/TrEMBL
    E7EN28, E7EUP0
    Related
    ENSP00000423787.1, ENST00000509896.5
    Conserved Domains (8) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882 → 934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1208 → 1271
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:635 → 856
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:944 → 969
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:942 → 1208
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  6. XM_017007941.1 → XP_016863430.1  adhesion G protein-coupled receptor L3 isoform X18

    UniProtKB/TrEMBL
    E7ESV6, E7EX52
    Related
    ENSP00000425033.1, ENST00000511324.5

  7. XM_017007933.1 → XP_016863422.1  adhesion G protein-coupled receptor L3 isoform X6

    UniProtKB/TrEMBL
    E7ETE3

  8. XM_017007936.1 → XP_016863425.1  adhesion G protein-coupled receptor L3 isoform X8

    UniProtKB/TrEMBL
    E7ETE3

  9. XM_047449935.1 → XP_047305891.1  adhesion G protein-coupled receptor L3 isoform X4

  10. XM_011531791.2 → XP_011530093.1  adhesion G protein-coupled receptor L3 isoform X12

    UniProtKB/TrEMBL
    E7ETE3
    Conserved Domains (7) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:869 → 921
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    cd16005
    Location:929 → 1186
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1186 → 1515
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:636 → 843
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  11. XM_047449934.1 → XP_047305890.1  adhesion G protein-coupled receptor L3 isoform X3

  12. XM_047449942.1 → XP_047305898.1  adhesion G protein-coupled receptor L3 isoform X17

  13. XM_017007934.1 → XP_016863423.1  adhesion G protein-coupled receptor L3 isoform X7

    UniProtKB/TrEMBL
    E7ETE3

  14. XM_047449943.1 → XP_047305899.1  adhesion G protein-coupled receptor L3 isoform X19

  15. XM_047449937.1 → XP_047305893.1  adhesion G protein-coupled receptor L3 isoform X9

  16. XM_047449936.1 → XP_047305892.1  adhesion G protein-coupled receptor L3 isoform X5

  17. XM_047449938.1 → XP_047305894.1  adhesion G protein-coupled receptor L3 isoform X10

  18. XM_047449939.1 → XP_047305895.1  adhesion G protein-coupled receptor L3 isoform X13

  19. XM_047449944.1 → XP_047305900.1  adhesion G protein-coupled receptor L3 isoform X20

    Related
    ENSP00000421476.1, ENST00000507164.5

  20. XM_047449945.1 → XP_047305901.1  adhesion G protein-coupled receptor L3 isoform X21

  21. XM_017007930.1 → XP_016863419.1  adhesion G protein-coupled receptor L3 isoform X1

    UniProtKB/TrEMBL
    E7ETE3

  22. XM_017007937.1 → XP_016863426.1  adhesion G protein-coupled receptor L3 isoform X11

    UniProtKB/TrEMBL
    E7EW95

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    64638264..65515643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349474.1 → XP_054205449.1  adhesion G protein-coupled receptor L3 isoform X14

  2. XM_054349475.1 → XP_054205450.1  adhesion G protein-coupled receptor L3 isoform X15

  3. XM_054349460.1 → XP_054205435.1  adhesion G protein-coupled receptor L3 isoform X1

  4. XM_054349461.1 → XP_054205436.1  adhesion G protein-coupled receptor L3 isoform X2

    UniProtKB/TrEMBL
    E7EUW2

  5. XM_054349477.1 → XP_054205452.1  adhesion G protein-coupled receptor L3 isoform X16

    UniProtKB/TrEMBL
    E7EUP0

  6. XM_054349479.1 → XP_054205454.1  adhesion G protein-coupled receptor L3 isoform X18

    UniProtKB/TrEMBL
    E7ESV6

  7. XM_054349465.1 → XP_054205440.1  adhesion G protein-coupled receptor L3 isoform X6

  8. XM_054349467.1 → XP_054205442.1  adhesion G protein-coupled receptor L3 isoform X8

  9. XM_054349463.1 → XP_054205438.1  adhesion G protein-coupled receptor L3 isoform X4

  10. XM_054349471.1 → XP_054205446.1  adhesion G protein-coupled receptor L3 isoform X12

  11. XM_054349462.1 → XP_054205437.1  adhesion G protein-coupled receptor L3 isoform X3

  12. XM_054349478.1 → XP_054205453.1  adhesion G protein-coupled receptor L3 isoform X17

  13. XM_054349466.1 → XP_054205441.1  adhesion G protein-coupled receptor L3 isoform X7

  14. XM_054349480.1 → XP_054205455.1  adhesion G protein-coupled receptor L3 isoform X19

  15. XM_054349468.1 → XP_054205443.1  adhesion G protein-coupled receptor L3 isoform X9

  16. XM_054349464.1 → XP_054205439.1  adhesion G protein-coupled receptor L3 isoform X5

  17. XM_054349469.1 → XP_054205444.1  adhesion G protein-coupled receptor L3 isoform X10

  18. XM_054349472.1 → XP_054205447.1  adhesion G protein-coupled receptor L3 isoform X22

  19. XM_054349473.1 → XP_054205448.1  adhesion G protein-coupled receptor L3 isoform X13

  20. XM_054349481.1 → XP_054205456.1  adhesion G protein-coupled receptor L3 isoform X20

  21. XM_054349482.1 → XP_054205457.1  adhesion G protein-coupled receptor L3 isoform X21

  22. XM_054349476.1 → XP_054205451.1  adhesion G protein-coupled receptor L3 isoform X23

  23. XM_054349459.1 → XP_054205434.1  adhesion G protein-coupled receptor L3 isoform X1

  24. XM_054349470.1 → XP_054205445.1  adhesion G protein-coupled receptor L3 isoform X11

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HAR2.2 GenPept UniProtKB/Swiss-Prot:Q9HAR2

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