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ARHGEF12 Rho guanine nucleotide exchange factor 12 [ Homo sapiens (human) ]

Gene ID: 23365, updated on 3-Apr-2024

Summary

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Official Symbol
ARHGEF12provided by HGNC
Official Full Name
Rho guanine nucleotide exchange factor 12provided by HGNC
Primary source
HGNC:HGNC:14193
See related
Ensembl:ENSG00000196914 MIM:604763; AllianceGenome:HGNC:14193
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LARG; PRO2792
Summary
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in kidney (RPKM 33.3), thyroid (RPKM 28.1) and 25 other tissues See more
Orthologs
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Genomic context

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See ARHGEF12 in Genome Data Viewer
Location:
11q23.3
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (120336413..120489937)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (120360067..120513690)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (120207122..120360646)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369531 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:120146894-120147083 Neighboring gene POU class 2 homeobox 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:120177487-120177989 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:120176405-120176922 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_19560 and experimental_19565 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:120184592 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:120193421-120193580 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3990 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3989 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:120195689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3991 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:120224214-120224428 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:120249395 Neighboring gene TLC domain containing 5 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:120288060 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:120305787 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:120306759 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:120313899 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:120345004 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:120350393 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:120356317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3992 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3993 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:120386966-120387568 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:120387569-120388170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:120402421-120402957 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:120418648-120419393 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:120435257-120435837 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:120435838-120436417 Neighboring gene uncharacterized LOC107984400 Neighboring gene glutamate ionotropic receptor kainate type subunit 4 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:120479691-120480414 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:120480713-120481226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5639 Neighboring gene elongin C pseudogene 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Local RhoA activation induces cytokinetic furrows independent of spindle position and cell cycle stage. Wagner E, et al. J Cell Biol, 2016 Jun 20. PMID 27298323, Free PMC Article
  2. ARHGEF12 influences the risk of glaucoma by increasing intraocular pressure. Springelkamp H, et al. Hum Mol Genet, 2015 May 1. PMID 25637523
  3. Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission. Martz MK, et al. Mol Biol Cell, 2013 Sep. PMID 23885121, Free PMC Article
  4. LARG links histamine-H1-receptor-activated Gq to Rho-GTPase-dependent signaling pathways. Pfreimer M, et al. Cell Signal, 2012 Mar. PMID 22100544
  5. Real-time NMR study of guanine nucleotide exchange and activation of RhoA by PDZ-RhoGEF. Gasmi-Seabrook GM, et al. J Biol Chem, 2010 Feb 19. PMID 20018869, Free PMC Article

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Targeting ARHGEF12 promotes neuroblastoma differentiation, MYCN degradation, and reduces tumorigenicity.
    Title: Targeting ARHGEF12 promotes neuroblastoma differentiation, MYCN degradation, and reduces tumorigenicity.
  2. ArhGEF12 activates Rap1A and not RhoA in human dermal microvascular endothelial cells to reduce tumor necrosis factor-induced leak.
    Title: ArhGEF12 activates Rap1A and not RhoA in human dermal microvascular endothelial cells to reduce tumor necrosis factor-induced leak.
  3. ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients.
    Title: ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients.
  4. Data show that phosphorylation of ribosomal protein S6 kinase 2 (RSK2) at threonine 577 is essential for leukemia-associated RhoGEF (LARG)-dependent Rho GTPase activation.
    Title: RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases.
  5. We studied the function of LARG in murine and human megakaryocytes and platelets with Larg knockout (KO), shRNA-mediated knockdown and small molecule-mediated inhibition. We found that LARG is important for human, but not murine, megakaryocyte maturation.
    Title: Leukaemia-associated Rho guanine nucleotide exchange factor (LARG) plays an agonist specific role in platelet function through RhoA activation.
  6. that leukemia-associated Rho guanine-nucleotide exchange factor can be directly phosphorylated by cyclin-dependent kinase 1
    Title: Mitotic-dependent phosphorylation of leukemia-associated RhoGEF (LARG) by Cdk1.
  7. Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF and leukemia-associated RhoGEF (LARG), use their PDZ domains to bind class B plexins and play critical roles in signaling.
    Title: Secondary PDZ domain-binding site on class B plexins enhances the affinity for PDZ-RhoGEF.
  8. this study identified a novel association between IOP and ARHGEF12.
    Title: ARHGEF12 influences the risk of glaucoma by increasing intraocular pressure.
  9. TGF-beta regulates LARG and GEF-H1 during epithelial-mesenchymal transition to affect stiffening response to force and cell invasion.
    Title: TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion.
  10. LARG is a novel and temporally distinct Rho Guanine Nucleotide Exchange Factor required for completion of abscission.
    Title: Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of Rho guanine nucleotide exchange factor 12 (ARHGEF12) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with Rho guanine nucleotide exchange factor (GEF) 12 (ARHGEF12) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0382, DKFZp686O2372

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 12
Names
KMT2A/ARHGEF12 fusion protein
Rho guanine nucleotide exchange factor (GEF) 12
leukemia-associated RhoGEF
leukemia-associated rho guanine nucleotide exchange factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027960.1 RefSeqGene

    Range
    4505..158029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001198665.2 → NP_001185594.1  rho guanine nucleotide exchange factor 12 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF180681, AK304316, AP000758, AP001150, BC063117
    Consensus CDS
    CCDS55794.1
    UniProtKB/TrEMBL
    A0A2X0SFF5
    Related
    ENSP00000349056.3, ENST00000356641.7
    Conserved Domains (4) summary
    cd08754
    Location:330 → 551
    RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
    cd00992
    Location:52 → 126
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13390
    Location:976 → 1113
    PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:772 → 957
    RhoGEF; RhoGEF domain

  2. NM_001301084.2 → NP_001288013.1  rho guanine nucleotide exchange factor 12 isoform 3

    See identical proteins and their annotated locations for NP_001288013.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate first exon and initiates translation at a downstream AUG compared to variant 1. Thd resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AF180681, AP000659, AP000758, BX647785
    Consensus CDS
    CCDS76487.1
    UniProtKB/TrEMBL
    A0A2X0SFF5, E9PMR6
    Related
    ENSP00000432984.1, ENST00000532993.5
    Conserved Domains (4) summary
    cd08754
    Location:246 → 467
    RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
    cd00992
    Location:2 → 42
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13390
    Location:892 → 1029
    PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:688 → 873
    RhoGEF; RhoGEF domain

  3. NM_015313.3 → NP_056128.1  rho guanine nucleotide exchange factor 12 isoform 1

    See identical proteins and their annotated locations for NP_056128.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF180681, AK304316, AP000758, AP001150, BC063117
    Consensus CDS
    CCDS41727.1
    UniProtKB/Swiss-Prot
    O15086, Q6P526, Q9NZN5
    UniProtKB/TrEMBL
    A0A2X0SFF5
    Related
    ENSP00000380942.2, ENST00000397843.7
    Conserved Domains (4) summary
    cd08754
    Location:349 → 570
    RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
    cd00992
    Location:71 → 145
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13390
    Location:995 → 1132
    PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:791 → 976
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    120336413..120489937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718805.4 → XP_006718868.1  rho guanine nucleotide exchange factor 12 isoform X1

    UniProtKB/TrEMBL
    A0A2X0SFF5
    Conserved Domains (4) summary
    cd08754
    Location:324 → 545
    RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
    cd00992
    Location:71 → 145
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13390
    Location:970 → 1107
    PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:766 → 951
    RhoGEF; RhoGEF domain

  2. XM_047426659.1 → XP_047282615.1  rho guanine nucleotide exchange factor 12 isoform X2

  3. XM_047426661.1 → XP_047282617.1  rho guanine nucleotide exchange factor 12 isoform X5

  4. XM_047426660.1 → XP_047282616.1  rho guanine nucleotide exchange factor 12 isoform X3

  5. XM_017017420.2 → XP_016872909.1  rho guanine nucleotide exchange factor 12 isoform X4

    UniProtKB/TrEMBL
    A0A2X0SFF5
    Conserved Domains (4) summary
    cd08754
    Location:290 → 511
    RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
    smart00325
    Location:732 → 917
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:52 → 126
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13390
    Location:936 → 1073
    PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  6. XM_047426662.1 → XP_047282618.1  rho guanine nucleotide exchange factor 12 isoform X7

  7. XM_047426665.1 → XP_047282621.1  rho guanine nucleotide exchange factor 12 isoform X6

    UniProtKB/TrEMBL
    E9PMR6

  8. XM_011542720.3 → XP_011541022.1  rho guanine nucleotide exchange factor 12 isoform X6

    See identical proteins and their annotated locations for XP_011541022.1

    UniProtKB/TrEMBL
    A0A2X0SFF5, E9PMR6
    Conserved Domains (4) summary
    cd08754
    Location:246 → 467
    RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
    cd00992
    Location:2 → 42
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13390
    Location:892 → 1029
    PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:688 → 873
    RhoGEF; RhoGEF domain

  9. XM_047426666.1 → XP_047282622.1  rho guanine nucleotide exchange factor 12 isoform X8

  10. XM_047426663.1 → XP_047282619.1  rho guanine nucleotide exchange factor 12 isoform X6

    UniProtKB/TrEMBL
    E9PMR6

  11. XM_047426667.1 → XP_047282623.1  rho guanine nucleotide exchange factor 12 isoform X9

  12. XM_047426668.1 → XP_047282624.1  rho guanine nucleotide exchange factor 12 isoform X8

  13. XM_017017421.2 → XP_016872910.1  rho guanine nucleotide exchange factor 12 isoform X6

    UniProtKB/TrEMBL
    A0A2X0SFF5, E9PMR6
    Conserved Domains (4) summary
    cd08754
    Location:246 → 467
    RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
    cd00992
    Location:2 → 42
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13390
    Location:892 → 1029
    PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:688 → 873
    RhoGEF; RhoGEF domain

  14. XM_047426670.1 → XP_047282626.1  rho guanine nucleotide exchange factor 12 isoform X10

  15. XM_047426664.1 → XP_047282620.1  rho guanine nucleotide exchange factor 12 isoform X6

    UniProtKB/TrEMBL
    E9PMR6

  16. XM_047426669.1 → XP_047282625.1  rho guanine nucleotide exchange factor 12 isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    120360067..120513690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368208.1 → XP_054224183.1  rho guanine nucleotide exchange factor 12 isoform X6

    UniProtKB/TrEMBL
    E9PMR6

  2. XM_054368210.1 → XP_054224185.1  rho guanine nucleotide exchange factor 12 isoform X6

    UniProtKB/TrEMBL
    E9PMR6

  3. XM_054368215.1 → XP_054224190.1  rho guanine nucleotide exchange factor 12 isoform X9

  4. XM_054368214.1 → XP_054224189.1  rho guanine nucleotide exchange factor 12 isoform X8

  5. XM_054368216.1 → XP_054224191.1  rho guanine nucleotide exchange factor 12 isoform X8

  6. XM_054368203.1 → XP_054224178.1  rho guanine nucleotide exchange factor 12 isoform X1

  7. XM_054368204.1 → XP_054224179.1  rho guanine nucleotide exchange factor 12 isoform X2

  8. XM_054368207.1 → XP_054224182.1  rho guanine nucleotide exchange factor 12 isoform X5

  9. XM_054368205.1 → XP_054224180.1  rho guanine nucleotide exchange factor 12 isoform X3

  10. XM_054368206.1 → XP_054224181.1  rho guanine nucleotide exchange factor 12 isoform X4

  11. XM_054368209.1 → XP_054224184.1  rho guanine nucleotide exchange factor 12 isoform X7

  12. XM_054368213.1 → XP_054224188.1  rho guanine nucleotide exchange factor 12 isoform X6

    UniProtKB/TrEMBL
    E9PMR6

  13. XM_054368212.1 → XP_054224187.1  rho guanine nucleotide exchange factor 12 isoform X6

    UniProtKB/TrEMBL
    E9PMR6

  14. XM_054368218.1 → XP_054224193.1  rho guanine nucleotide exchange factor 12 isoform X10

  15. XM_054368211.1 → XP_054224186.1  rho guanine nucleotide exchange factor 12 isoform X6

    UniProtKB/TrEMBL
    E9PMR6

  16. XM_054368217.1 → XP_054224192.1  rho guanine nucleotide exchange factor 12 isoform X8

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NZN5.1 GenPept UniProtKB/Swiss-Prot:Q9NZN5

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