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CORO1C coronin 1C [ Homo sapiens (human) ]

Gene ID: 23603, updated on 7-Apr-2024

Summary

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Official Symbol
CORO1Cprovided by HGNC
Official Full Name
coronin 1Cprovided by HGNC
Primary source
HGNC:HGNC:2254
See related
Ensembl:ENSG00000110880 MIM:605269; AllianceGenome:HGNC:2254
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCRNN4
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Expression
Ubiquitous expression in endometrium (RPKM 30.8), lung (RPKM 27.0) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
12q24.11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (108645109..108731518, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (108619700..108706142, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (109038885..109125294, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6972 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6973 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4830 Neighboring gene selectin P ligand Neighboring gene microRNA 4496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6974 Neighboring gene RNA, U7 small nuclear 169 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:109085249-109085930 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:109085931-109086612 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:109087326-109087838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6976 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:109095295-109095827 Neighboring gene Sharpr-MPRA regulatory region 4572 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6977 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:109108143-109108833 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:109108834-109109524 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:109109525-109110214 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4831 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:109125165-109125968 Neighboring gene uncharacterized LOC105369969 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:109128377-109128878 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4833 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:109164153-109164653 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6978 Neighboring gene small nucleolar RNA SNORA40 Neighboring gene slingshot protein phosphatase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Coronin 1C, Regulated by Multiple microRNAs, Facilitates Cancer Cell Aggressiveness in Pancreatic Ductal Adenocarcinoma. Fukuda K, et al. Genes (Basel), 2023 Apr 27. PMID 37239355, Free PMC Article
  2. CORO1C, a novel PAK4 binding protein, recruits phospho-PAK4 at serine 99 to the leading edge and promotes the migration of gastric cancer cells. Li X, et al. Acta Biochim Biophys Sin (Shanghai), 2022 May 25. PMID 35593474, Free PMC Article
  3. Circ_0020123 plays an oncogenic role in non-small cell lung cancer depending on the regulation of miR-512-3p/CORO1C. Zhang H, et al. Thorac Cancer, 2022 May. PMID 35388975, Free PMC Article
  4. A peptide CORO1C-47aa encoded by the circular noncoding RNA circ-0000437 functions as a negative regulator in endometrium tumor angiogenesis. Li F, et al. J Biol Chem, 2021 Nov. PMID 34534547, Free PMC Article
  5. miR-26 suppresses renal cell cancer via down-regulating coronin-3. Wang XJ, et al. Mol Cell Biochem, 2020 Jan. PMID 31595425

See all (163) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Coronin 1C, Regulated by Multiple microRNAs, Facilitates Cancer Cell Aggressiveness in Pancreatic Ductal Adenocarcinoma.
    Title: Coronin 1C, Regulated by Multiple microRNAs, Facilitates Cancer Cell Aggressiveness in Pancreatic Ductal Adenocarcinoma.
  2. CORO1C, a novel PAK4 binding protein, recruits phospho-PAK4 at serine 99 to the leading edge and promotes the migration of gastric cancer cells.
    Title: CORO1C, a novel PAK4 binding protein, recruits phospho-PAK4 at serine 99 to the leading edge and promotes the migration of gastric cancer cells.
  3. CircRNA CORO1C Regulates miR-654-3p/USP7 Axis to Mediate Laryngeal Squamous Cell Carcinoma Progression.
    Title: CircRNA CORO1C Regulates miR-654-3p/USP7 Axis to Mediate Laryngeal Squamous Cell Carcinoma Progression.
  4. Circ_0020123 plays an oncogenic role in non-small cell lung cancer depending on the regulation of miR-512-3p/CORO1C.
    Title: Circ_0020123 plays an oncogenic role in non-small cell lung cancer depending on the regulation of miR-512-3p/CORO1C.
  5. Circ_0025039 acts an oncogenic role in the progression of non-small cell lung cancer through miR-636-dependent regulation of CORO1C.
    Title: Circ_0025039 acts an oncogenic role in the progression of non-small cell lung cancer through miR-636-dependent regulation of CORO1C.
  6. Cytoplasmic RAD23B interacts with CORO1C to synergistically promote colorectal cancer progression and metastasis.
    Title: Cytoplasmic RAD23B interacts with CORO1C to synergistically promote colorectal cancer progression and metastasis.
  7. A peptide CORO1C-47aa encoded by the circular noncoding RNA circ-0000437 functions as a negative regulator in endometrium tumor angiogenesis.
    Title: A peptide CORO1C-47aa encoded by the circular noncoding RNA circ-0000437 functions as a negative regulator in endometrium tumor angiogenesis.
  8. Circ_0003998 Regulates the Progression and Docetaxel Sensitivity of DTX-Resistant Non-Small Cell Lung Cancer Cells by the miR-136-5p/CORO1C Axis.
    Title: Circ_0003998 Regulates the Progression and Docetaxel Sensitivity of DTX-Resistant Non-Small Cell Lung Cancer Cells by the miR-136-5p/CORO1C Axis.
  9. MiR-206 may suppress non-small lung cancer metastasis by targeting CORO1C.
    Title: MiR-206 may suppress non-small lung cancer metastasis by targeting CORO1C.
  10. miR-26 suppresses renal cell cancer via down-regulating coronin-3.
    Title: miR-26 suppresses renal cell cancer via down-regulating coronin-3.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in activation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in corpus callosum development IEA
Inferred from Electronic Annotation
more info
  
involved_in endosomal transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in endosome fission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in endosome membrane tubulation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in establishment of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in membrane fission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phagocytosis TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of lamellipodium morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of epithelial cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of fibroblast migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of focal adhesion assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of ruffle assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of substrate adhesion-dependent cell spreading IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in ventricular system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of flotillin complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in focal adhesion HDA PubMed 
NOT colocalizes_with focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
  
located_in sarcomere IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
coronin-1C
Names
coronin, actin binding protein, 1C
coronin-3

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105237.2 → NP_001098707.1  coronin-1C isoform a

    See identical proteins and their annotated locations for NP_001098707.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC007569, AM849478, BM677390
    Consensus CDS
    CCDS61236.1
    UniProtKB/TrEMBL
    B3KN06, Q53G58
    Related
    ENSP00000394496.2, ENST00000420959.6
    Conserved Domains (5) summary
    pfam05873
    Location:471 → 527
    Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
    pfam08953
    Location:59 → 116
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:396 → 438
    WD40_4; Type of WD40 repeat
    sd00039
    Location:89 → 131
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:128 → 353
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001276471.2 → NP_001263400.1  coronin-1C isoform b

    See identical proteins and their annotated locations for NP_001263400.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate first exon and initiates translation at a downstream AUG compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC007569, AK096363, BM677390
    Consensus CDS
    CCDS9120.1
    UniProtKB/Swiss-Prot
    A7MAP0, A7MAP1, B3KU12, Q9NSK5, Q9ULV4
    UniProtKB/TrEMBL
    B3KN06, Q53G58
    Related
    ENSP00000438341.1, ENST00000541050.5
    Conserved Domains (3) summary
    sd00039
    Location:36 → 78
    7WD40; WD40 repeat [structural motif]
    pfam05873
    Location:418 → 474
    Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
    cl25676
    Location:8 → 402
    WD40_4; Type of WD40 repeat

  3. NM_014325.4 → NP_055140.1  coronin-1C isoform b

    See identical proteins and their annotated locations for NP_055140.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate first exon and initiates translation at a downstream AUG compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AB030656, AC007569, BM677390
    Consensus CDS
    CCDS9120.1
    UniProtKB/Swiss-Prot
    A7MAP0, A7MAP1, B3KU12, Q9NSK5, Q9ULV4
    UniProtKB/TrEMBL
    B3KN06, Q53G58
    Related
    ENSP00000261401.3, ENST00000261401.8
    Conserved Domains (3) summary
    sd00039
    Location:36 → 78
    7WD40; WD40 repeat [structural motif]
    pfam05873
    Location:418 → 474
    Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
    cl25676
    Location:8 → 402
    WD40_4; Type of WD40 repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    108645109..108731518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    108619700..108706142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ULV4.1 GenPept UniProtKB/Swiss-Prot:Q9ULV4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous