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EID1 EP300 interacting inhibitor of differentiation 1 [ Homo sapiens (human) ]

Gene ID: 23741, updated on 2-May-2024

Summary

Official Symbol
EID1provided by HGNC
Official Full Name
EP300 interacting inhibitor of differentiation 1provided by HGNC
Primary source
HGNC:HGNC:1191
See related
Ensembl:ENSG00000255302 MIM:605894; AllianceGenome:HGNC:1191
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRI1; EID-1; RBP21; PTD014; C15orf3; PNAS-22; IRO45620
Summary
Enables histone acetyltransferase binding activity and histone acetyltransferase regulator activity. Involved in cell differentiation and negative regulation of transcription, DNA-templated. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasmic ribonucleoprotein granule and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

Location:
15q21.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (48878134..48880173)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (46686343..46688382)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (49170331..49172370)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene oxidation resistance 1 pseudogene Neighboring gene centrosomal protein 152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9377 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:49090426-49090965 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:49099693-49100193 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:49102416-49102977 Neighboring gene uncharacterized LOC124903487 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:49103270-49103460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9378 Neighboring gene MPRA-validated peak2329 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr15:49136024-49136191 Neighboring gene Sharpr-MPRA regulatory region 4235 Neighboring gene SHC adaptor protein 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:49166520-49166841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9380 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:49180996-49181177 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:49204976-49206175 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:49237854-49239053 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:49254590-49255092 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:49255093-49255594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9381 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:49267886-49268121 Neighboring gene keratin 8 pseudogene 24 Neighboring gene SECIS binding protein 2 like Neighboring gene MPRA-validated peak2330 silencer Neighboring gene MPRA-validated peak2331 silencer Neighboring gene Sharpr-MPRA regulatory region 10237 Neighboring gene RNA, 7SL, cytoplasmic 577, pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC138883, MGC138884

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone acetyltransferase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
EP300-interacting inhibitor of differentiation 1
Names
21 kDa pRb-associated protein
CREBBP/EP300 inhibitor 1
CREBBP/EP300 inhibitory protein 1
E1A-like inhibitor of differentiation 1
NB4 apoptosis related protein
Rb- and p300-binding protein EID-1
retinoblastoma protein-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014335.3NP_055150.1  EP300-interacting inhibitor of differentiation 1

    See identical proteins and their annotated locations for NP_055150.1

    Status: VALIDATED

    Source sequence(s)
    AF349444, AI360508
    Consensus CDS
    CCDS53941.1
    UniProtKB/Swiss-Prot
    B2RD11, Q8N7I4, Q9BZT9, Q9Y6B2
    UniProtKB/TrEMBL
    H0YN68
    Related
    ENSP00000431162.2, ENST00000530028.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    48878134..48880173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    46686343..46688382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)