Pde10a phosphodiesterase 10A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pde10aprovided by MGI
Official Full Name: phosphodiesterase 10Aprovided by MGI
Primary source: MGI:MGI:1345143
See related: Ensembl:ENSMUSG00000023868 AllianceGenome:MGI:1345143
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables 3',5'-cyclic-nucleotide phosphodiesterase activity. Acts upstream of or within regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of protein kinase A signaling. Predicted to be located in membrane and perikaryon. Is expressed in alimentary system; cardiovascular system; nervous system; and sensory organ. Orthologous to human PDE10A (phosphodiesterase 10A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 7.5), cortex adult (RPKM 4.9) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A1; 17 4.96 cM

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (8742719..9205480)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (8525187..8986648)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphodiesterase 10A deactivation induces long-term neurological recovery, Peri-infarct remodeling and pyramidal tract plasticity after transient focal cerebral ischemia in mice.
Title: Phosphodiesterase 10A deactivation induces long-term neurological recovery, Peri-infarct remodeling and pyramidal tract plasticity after transient focal cerebral ischemia in mice.
Role of PDE10A in vascular smooth muscle cell hyperplasia and pathological vascular remodelling.
Title: Role of PDE10A in vascular smooth muscle cell hyperplasia and pathological vascular remodelling.
Pivotal role of phosphodiesterase 10A in the integration of dopamine signals in mice striatal D1 and D2 medium-sized spiny neurones.
Title: Pivotal role of phosphodiesterase 10A in the integration of dopamine signals in mice striatal D(1) and D(2) medium-sized spiny neurones.
Phosphodiesterase 10A Is a Key Mediator of Lung Inflammation.
Title: Phosphodiesterase 10A Is a Key Mediator of Lung Inflammation.
study elucidates a novel role for PDE10A in the regulation of pathological cardiac remodeling and development of heart failure. Given that PDE10A has been proven to be a safe drug target, PDE10A inhibition may represent a novel therapeutic strategy for preventing and treating cardiac diseases associated with cardiac remodeling.
Title: A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction.
Through a combination of pharmacological and genetic tools, study provides convergent evidence of D2 (rather than D1) pathway dominant effects of PDE10A inhibition in rodents
Title: Phosphodiesterase 10A inhibitor, MP-10 (PF-2545920), produces greater induction of c-Fos in dopamine D2 neurons than in D1 neurons in the neostriatum.
A knock-in mouse model carrying the homologous p.Tyr97Cys variant had decreased striatal PDE10A and also displayed motor abnormalities
Title: Biallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a Hyperkinetic Movement Disorder with Onset in Infancy.
Its alteration leads to a cause of Huntington disease.
Title: Early decrease of type 1 cannabinoid receptor binding and phosphodiesterase 10A activity in vivo in R6/2 Huntington mice.
phosphorylation of PDE10 has an impact on the interaction with other signaling proteins in the corpus striatum
Title: Phosphodiesterase 10A Is Tethered to a Synaptic Signaling Complex in Striatum.
data show that PDE10A plays a pivotal role in striatal signaling and striatum-mediated salience attribution
Title: Genetic deletion of PDE10A selectively impairs incentive salience attribution and decreases medium spiny neuron excitability.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH69933 (e-PCR)
- UniSTS:78643

D17Mit247 (e-PCR), detects polymorphism
- UniSTS:128059

D17Pri2 (e-PCR), detects polymorphism
- UniSTS:142156

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cAMP binding	ISO Inferred from Sequence Orthology more info
enables cGMP binding	IEA Inferred from Electronic Annotation more info
enables cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables cyclic-nucleotide phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cGMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein kinase A signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Names: dual-substrate cAMP and cGMP, cyclic nucleotide phosphodiesterase

NP_001277636.1

EC 3.1.4.17

NP_001334250.1

EC 3.1.4.17

NP_035996.2

EC 3.1.4.17

XP_006523379.1

EC 3.1.4.17

XP_006523381.1

EC 3.1.4.17

XP_006523382.1

EC 3.1.4.17

XP_006523383.1

EC 3.1.4.17

XP_006523384.1

EC 3.1.4.17

XP_006523386.1

EC 3.1.4.17

XP_017172949.1

EC 3.1.4.17

XP_017172951.1

EC 3.1.4.17

XP_036016478.1

EC 3.1.4.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290707.1 → NP_001277636.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 1

See identical proteins and their annotated locations for NP_001277636.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC122893, AC154579, AK039249

Consensus CDS

CCDS88988.1

UniProtKB/TrEMBL

A0A384DV92, Q7TPG1

Related

ENSMUSP00000111389.3, ENSMUST00000115724.9

Conserved Domains (3) summary

smart00065
Location:331 → 486

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:578 → 810

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam01590
Location:155 → 298

GAF; GAF domain
NM_001347321.1 → NP_001334250.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus compared to isoform 1.

Source sequence(s)

AC122893, BP753427

Consensus CDS

CCDS84274.1

UniProtKB/TrEMBL

Q7TPG1

Related

ENSMUSP00000111385.2, ENSMUST00000115720.8
NM_011866.2 → NP_035996.2 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 2

See identical proteins and their annotated locations for NP_035996.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC104323, AK014090, AK039249

Consensus CDS

CCDS28384.1

UniProtKB/TrEMBL

Q7TPG1

Related

ENSMUSP00000086485.3, ENSMUST00000089085.10

Conserved Domains (3) summary

smart00065
Location:277 → 432

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:524 → 756

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam01590
Location:101 → 244

GAF; GAF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

8742719..9205480

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523318.5 → XP_006523381.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X3

UniProtKB/TrEMBL

Q7TPG1

Conserved Domains (3) summary

smart00065
Location:312 → 467

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:559 → 791

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam01590
Location:136 → 279

GAF; GAF domain
XM_036160585.1 → XP_036016478.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X7

UniProtKB/Swiss-Prot

Q3TLU6, Q3TRG6, Q69C21, Q8CA95, Q9WVI1

UniProtKB/TrEMBL

Q7TPG1

Related

ENSMUSP00000111380.2, ENSMUST00000115715.8

Conserved Domains (3) summary

smart00065
Location:271 → 426

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:518 → 750

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam01590
Location:95 → 238

GAF; GAF domain
XM_017317460.3 → XP_017172949.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1

UniProtKB/TrEMBL

Q7TPG1

Conserved Domains (3) summary

smart00065
Location:372 → 527

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:619 → 851

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam01590
Location:196 → 339

GAF; GAF domain
XM_006523316.3 → XP_006523379.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X2

UniProtKB/TrEMBL

Q7TPG1

Conserved Domains (3) summary

smart00065
Location:370 → 525

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:617 → 849

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam01590
Location:194 → 337

GAF; GAF domain
XM_017317462.2 → XP_017172951.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X9

Conserved Domains (1) summary

pfam01590
Location:383 → 526

GAF; GAF domain
XM_006523323.2 → XP_006523386.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X8

UniProtKB/TrEMBL

F8WHK3

Conserved Domains (3) summary

smart00065
Location:136 → 291

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:383 → 615

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam01590
Location:12 → 103

GAF; GAF domain
XM_006523319.5 → XP_006523382.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X4

UniProtKB/TrEMBL

Q7TPG1

Conserved Domains (3) summary

smart00065
Location:278 → 433

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:525 → 757

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam01590
Location:102 → 245

GAF; GAF domain
XM_006523321.5 → XP_006523384.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X6

UniProtKB/TrEMBL

Q7TPG1

Conserved Domains (3) summary

smart00065
Location:275 → 430

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:522 → 754

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam01590
Location:99 → 242

GAF; GAF domain
XM_006523320.5 → XP_006523383.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X5

See identical proteins and their annotated locations for XP_006523383.1

UniProtKB/TrEMBL

Q7TPG1, Q7TPG2

Conserved Domains (3) summary

smart00065
Location:278 → 433

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:525 → 757

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam01590
Location:102 → 245

GAF; GAF domain