Abce1 ATP-binding cassette, sub-family E member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abce1provided by MGI
Official Full Name: ATP-binding cassette, sub-family E member 1provided by MGI
Primary source: MGI:MGI:1195458
See related: Ensembl:ENSMUSG00000058355 AllianceGenome:MGI:1195458
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RLI; Oabp; RNS41; RNS4I; Rnaseli
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in liver E14 (RPKM 27.7), CNS E11.5 (RPKM 26.2) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C1; 8 37.77 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (80410071..80438369, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (79683442..79711740, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

our study pinpoints that Abce1 plays an important role in meiosis resumption, spindle integrity and chromosome alignment in meiotic oocytes
Title: Abce1 orchestrates M-phase entry and cytoskeleton architecture in mouse oocyte.
Expression of RNase L is a signal generated by NMDA receptor in cortical neurons. RNase L expression and RNA degradation may be events that cause neuronal damage induced by NMDA receptor activation.
Title: Enhanced expression of RNase L as a novel intracellular signal generated by NMDA receptors in mouse cortical neurons.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (4)
Transgenic (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

UniSTS:498297 (e-PCR)
- UniSTS:498297

Abce1 (e-PCR), detects polymorphism
- UniSTS:498297

RH126496 (e-PCR)
- UniSTS:163204

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables CTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables endoribonuclease inhibitor activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables ribonucleoside triphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal small subunit binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of endoribonuclease activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in rescue of stalled ribosome	ISO Inferred from Sequence Orthology more info
involved_in ribosomal subunit export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosome disassembly	ISO Inferred from Sequence Orthology more info
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational termination	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational termination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP-binding cassette sub-family E member 1

Names: ATP-binding cassette, sub-family E (OABP), member 1; ATP-binding cassette, subfamily E, member 1; RNS4l (Eye); RNase L inhibitor; ribonuclease 4 inhibitor; ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_015751.2 → NP_056566.2 ATP-binding cassette sub-family E member 1

See identical proteins and their annotated locations for NP_056566.2

Status: VALIDATED

Source sequence(s)

AK167370, AV213051, BB651928, CD564438

Consensus CDS

CCDS22438.1

UniProtKB/Swiss-Prot

P61222

UniProtKB/TrEMBL

Q3TIU8, Q3TJM9, Q3UHY8

Related

ENSMUSP00000079379.7, ENSMUST00000080536.8

Conserved Domains (1) summary

COG1245
Location:4 → 597

Rli1; Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis]