Agtr2 angiotensin II receptor, type 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Agtr2provided by RGD
Official Full Name: angiotensin II receptor, type 2provided by RGD
Primary source: RGD:2072
See related: Ensembl:ENSRNOG00000050006 AllianceGenome:RGD:2072
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AT2R; AT2-R; AT<sub>2</sub>R
Summary: Predicted to enable angiotensin type II receptor activity. Involved in several processes, including aldosterone secretion; animal organ development; and regulation of secretion. Located in perinuclear region of cytoplasm and plasma membrane. Used to study chronic kidney disease; congenital diaphragmatic hernia; glomerulonephritis (multiple); hypertension (multiple); and meconium aspiration syndrome. Biomarker of several diseases, including asthma; congestive heart failure; glomerulosclerosis (multiple); hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; end stage renal disease; hypoglycemia; intellectual disability; and vesicoureteral reflux. Orthologous to human AGTR2 (angiotensin II receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 176.0), Uterus (RPKM 25.3) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq34

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (116914320..116918504)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (112119876..112124060)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (119389480..119393845)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Angiotensin II type 2 receptor activation preserves megalin in the kidney and prevents proteinuria in high salt diet fed rats.
Title: Angiotensin II type 2 receptor activation preserves megalin in the kidney and prevents proteinuria in high salt diet fed rats.
The effect of AT1R-1166A/C and AT2R-1675A/G polymorphisms on susceptibility to preeclampsia: A systematic review and meta-analysis.
Title: The effect of AT1R-1166A/C and AT2R-1675A/G polymorphisms on susceptibility to preeclampsia: A systematic review and meta-analysis.
Relaxin Attenuates Organ Fibrosis via an Angiotensin Type 2 Receptor Mechanism in Aged Hypertensive Female Rats.
Title: Relaxin Attenuates Organ Fibrosis via an Angiotensin Type 2 Receptor Mechanism in Aged Hypertensive Female Rats.
The Expression of RAAS Key Receptors, Agtr2 and Bdkrb1, Is Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome.
Title: The Expression of RAAS Key Receptors, Agtr2 and Bdkrb1, Is Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome.
Activation of angiotensin type 2 receptor attenuates testosterone-induced hypertension and uterine vascular resistance in pregnant ratsdagger.
Title: Activation of angiotensin type 2 receptor attenuates testosterone-induced hypertension and uterine vascular resistance in pregnant rats†.
Estrogen normalizes maternal HFD-induced cardiac hypertrophy in offspring by regulating AT2R.
Title: Estrogen normalizes maternal HFD-induced cardiac hypertrophy in offspring by regulating AT2R.
Effects of renal ischemia injury on brain in diabetic and non-diabetic rats: Role of angiotensin II type 2 receptor and angiotensin-converting enzyme 2.
Title: Effects of renal ischemia injury on brain in diabetic and non-diabetic rats: Role of angiotensin II type 2 receptor and angiotensin-converting enzyme 2.
Ameliorative effect of AT2R and ACE2 activation on ischemic renal injury associated cardiac and hepatic dysfunction.
Title: Ameliorative effect of AT2R and ACE2 activation on ischemic renal injury associated cardiac and hepatic dysfunction.
Function of AT1 and AT2 receptors in atrial contractions from spontaneous hypertensive and diabetic-induced streptozotocin rats
Title: Function of AT1 and AT2 receptors in atrial contractions from spontaneous hypertensive and diabetic-induced streptozotocin rats.
Study found that activation of AT2R decrease insulin receptor expression and function in renal proximal tubule (RPT) cells from Wistar-Kyoto rats, whereas this inhibitory effect disturbed in RPT cells from spontaneously hypertensive rats. Results suggest that interaction between AT2R and insulin receptor may play an important role in the abnormal regulation of sodium excretion and consequently implicated in hypertension.
Title: Angiotensin II type 2 receptor inhibits expression and function of insulin receptor in rat renal proximal tubule cells.

Submit: New GeneRIF Correction See all GeneRIFs (179)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

dxmgh7 (e-PCR)
- UniSTS:120588

AW107640 (e-PCR)
- UniSTS:181279

RH139933 (e-PCR)
- UniSTS:222017

Agtr2 (e-PCR), detects polymorphism
- UniSTS:516681

UniSTS:496533 (e-PCR)
- UniSTS:496533

Agtr2 (e-PCR), detects polymorphism
- UniSTS:496533

DXWox27 (e-PCR)
- UniSTS:517781

PMC153509P1 (e-PCR)
- UniSTS:271257

Agtr2 (e-PCR), detects polymorphism
- UniSTS:265641

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	TAS Traceable Author Statement more info	PubMed
enables angiotensin type II receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables angiotensin type II receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables angiotensin type II receptor activity	ISO Inferred from Sequence Orthology more info
enables angiotensin type II receptor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	ISO Inferred from Sequence Orthology more info
involved_in angiotensin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brain renin-angiotensin system	ISO Inferred from Sequence Orthology more info
involved_in cell growth involved in cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dexamethasone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cerebellar cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dopamine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exploration behavior	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in intracellular sodium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in kidney morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of icosanoid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neurotrophin TRK receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of norepinephrine secretion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	TAS Traceable Author Statement more info	PubMed
involved_in nitric oxide-cGMP-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in nitric oxide-cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of metanephric glomerulus development	ISO Inferred from Sequence Orthology more info
involved_in regulation of metanephros size	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of systemic arterial blood pressure by circulatory renin-angiotensin	ISO Inferred from Sequence Orthology more info
involved_in renin-angiotensin regulation of aldosterone production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to organonitrogen compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in vasodilation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: type-2 angiotensin II receptor

Names: AT2; AT2 receptor; angiotensin II type 2 receptor; angiotensin receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012494.4 → NP_036626.1 type-2 angiotensin II receptor

See identical proteins and their annotated locations for NP_036626.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

P35351

UniProtKB/TrEMBL

B1WBL8

Related

ENSRNOP00000064709.1, ENSRNOT00000074269.2

Conserved Domains (1) summary

cd15191
Location:45 → 329

7tmA_AT2R; type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors