Apc APC regulator of WNT signaling pathway [ Rattus norvegicus (Norway rat) ]

Gene ID: 24205, updated on 11-Apr-2024

Summary

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Official Symbol: Apcprovided by RGD
Official Full Name: APC regulator of WNT signaling pathwayprovided by RGD
Primary source: RGD:2123
See related: Ensembl:ENSRNOG00000020423 AllianceGenome:RGD:2123
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RATAPC
Summary: Enables microtubule binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; negative regulation of cardiac muscle cell proliferation; and regulation of glutamate metabolic process. Located in several cellular components, including axonal growth cone; cell body fiber; and lateral plasma membrane. Part of protein-containing complex. Colocalizes with neuron projection and synapse. Used to study anemia; colon adenocarcinoma; colon cancer; and familial adenomatous polyposis. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer (multiple); familial adenomatous polyposis 1; hereditary desmoid disease; and medulloblastoma. Orthologous to human APC (APC regulator of WNT signaling pathway). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 510.2), Lung (RPKM 138.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Apc in Genome Data Viewer

Location:: 18p12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (26138382..26196021)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (25828558..25925511)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (27011710..27106323)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibitory effects of a selective prostaglandin E2 receptor antagonist RQ-15986 on inflammation-related colon tumorigenesis in APC-mutant rats.
Title: Inhibitory effects of a selective prostaglandin E2 receptor antagonist RQ-15986 on inflammation-related colon tumorigenesis in APC-mutant rats.
the miR-30 family/APC interaction is a potential mechanism for the transgenerational effects induced by the environmental chemical.
Title: Adenomatous polyposis coli as a predictor of environmental chemical-induced transgenerational effects related to male infertility.
Cdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons
Title: Cdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons.
Study shows APC is an RNA-binding protein and identify an RNA interactome; among the targets is beta2B-tubulin, known to be required in human neuron and axon migration; results identify APC as a platform binding functionally related protein and RNA networks, and suggest a self-organizing model for the microtubule to localize synthesis of its own subunits.
Title: APC is an RNA-binding protein, and its interactome provides a link to neural development and microtubule assembly.
APC is essential for maintenance of intestinal mucosal homeostasis and can consequently contribute to inflammatory bowel disease pathogenesis.
Title: Tumor suppressor APC protein is essential in mucosal repair from colonic inflammation through angiogenesis.
These results point to APC as a crucial regulator of intermediate filament organization.
Title: APC binds intermediate filaments and is required for their reorganization during cell migration.
APC and PSD-95 colocalize and form a protein complex in nerve fibers as well as in postsynaptic sites in matured neurons.
Title: Colocalization of APC and PSD-95 in the nerve fiber as well as in the post-synapse of matured neurons.
the Amer2-EB1-APC complex regulates cell migration by altering microtubule stability.
Title: Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration.
results identify a previously unknown APC regulatory pathway during growth-factor-induced cell extension and indicate that the GSK-3beta and ERK pathways act in parallel to regulate interactions between APC and the cytoskeleton during formation of cell extensions
Title: Mitogen-activated protein kinase (MAPK/ERK) regulates adenomatous polyposis coli during growth-factor-induced cell extension.
APC, through a direct interaction with the NPC (nuclear pore complex) protein Nup153 (nucleoporin 153), promotes the association of microtubules with the nuclear membrane.
Title: APC nuclear membrane association and microtubule polarity.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Apc (e-PCR), detects polymorphism
- UniSTS:141103

PMC122454P1 (e-PCR)
- UniSTS:270391

RH138935 (e-PCR)
- UniSTS:221021

UniSTS:237769 (e-PCR)
- UniSTS:237769

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	ISS Inferred from Sequence or Structural Similarity more info
NOT enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables dynein complex binding	IEA Inferred from Electronic Annotation more info
enables dynein complex binding	ISO Inferred from Sequence Orthology more info
enables gamma-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables gamma-catenin binding	IEA Inferred from Electronic Annotation more info
enables gamma-catenin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule plus-end binding	IEA Inferred from Electronic Annotation more info
enables microtubule plus-end binding	ISO Inferred from Sequence Orthology more info
enables microtubule plus-end binding	ISS Inferred from Sequence or Structural Similarity more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein kinase regulator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of acinar cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axis specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axonogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within canonical Wnt signaling pathway involved in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within canonical Wnt signaling pathway involved in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell division	ISO Inferred from Sequence Orthology more info
involved_in cell fate specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular component organization	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nerve growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within chromosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytoplasmic microtubule organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dorsal/ventral pattern formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell proliferation involved in prostate gland development	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of cell polarity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of fibroblast apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of fibroblast migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle development	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within metaphase/anaphase transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of microtubule depolymerization	ISO Inferred from Sequence Orthology more info
acts_upstream_of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly checkpoint signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle cell cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of acinar cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle G1/S phase transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial cell proliferation involved in prostate gland development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of microtubule depolymerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule depolymerization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in pancreas development	IEP Inferred from Expression Pattern more info	PubMed
involved_in pattern specification process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pattern specification process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within positive regulation of fibroblast apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to centrosome	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to centrosome	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pseudopodium assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of pseudopodium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within proximal/distal pattern formation	ISO Inferred from Sequence Orthology more info
involved_in regulation of attachment of spindle microtubules to kinetochore	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of attachment of spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of glutamate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in regulation of microtubule-based movement	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule-based process	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule-based process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of nitrogen compound metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in response to alcohol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skin development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somatic stem cell population maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within stem cell population maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thymus development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of Scrib-APC-beta-catenin complex	ISO Inferred from Sequence Orthology more info
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in adherens junction	ISS Inferred from Sequence or Structural Similarity more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
part_of beta-catenin destruction complex	IBA Inferred from Biological aspect of Ancestor more info
part_of beta-catenin destruction complex	IEA Inferred from Electronic Annotation more info
part_of beta-catenin destruction complex	ISO Inferred from Sequence Orthology more info
part_of beta-catenin destruction complex	ISS Inferred from Sequence or Structural Similarity more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	IEA Inferred from Electronic Annotation more info
part_of catenin complex	ISO Inferred from Sequence Orthology more info
located_in cell body fiber	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in cell projection membrane	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with cytoplasmic microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in neuron projection terminus	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: adenomatous polyposis coli protein

Names: APC, WNT signaling pathway regulator; WNT signaling pathway regulator; adenomatosis polyposis coli

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012499.1 → NP_036631.1 adenomatous polyposis coli protein

See identical proteins and their annotated locations for NP_036631.1

Status: PROVISIONAL

Source sequence(s)

D38629

UniProtKB/Swiss-Prot

P70478

UniProtKB/TrEMBL

A6J2T3, G3V8Q9

Related

ENSRNOP00000027691.1, ENSRNOT00000027691.4

Conserved Domains (15) summary

cd00020
Location:609 → 729

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam05923
Location:1635 → 1659

APC_crr; APC cysteine-rich region

pfam05924
Location:2033 → 2052

SAMP; SAMP Motif

pfam05937
Location:2670 → 2842

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2223 → 2568

APC_basic; APC basic domain

pfam11414
Location:125 → 205

Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein

pfam16629
Location:730 → 1017

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:1034 → 1133

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1280 → 1365

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1660 → 1716

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1737 → 1837

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1874 → 1945

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam16689
Location:4 → 55

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

sd00043
Location:463 → 506

ARM; armadillo repeat [structural motif]

cl21478
Location:190 → 273

ATP-synt_B; ATP synthase B/B' CF(0)