Gnb1 G protein subunit beta 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gnb1provided by RGD
Official Full Name: G protein subunit beta 1provided by RGD
Primary source: RGD:2718
See related: Ensembl:ENSRNOG00000016638 AllianceGenome:RGD:2718
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables alkylglycerophosphoethanolamine phosphodiesterase activity and spectrin binding activity. Involved in G protein-coupled receptor signaling pathway and positive regulation of cytosolic calcium ion concentration. Acts upstream of or within cardiac muscle cell apoptotic process and cellular response to hypoxia. Located in several cellular components, including cell body; photoreceptor inner segment; and photoreceptor outer segment membrane. Part of heterotrimeric G-protein complex. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; autosomal dominant non-syndromic intellectual disability 42; and myelodysplastic syndrome. Orthologous to human GNB1 (G protein subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 1154.7), Lung (RPKM 759.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (171357778..171424489)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (166075508..166142223)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (172914025..172981403)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PAX8-AS1 knockdown facilitates cell growth and inactivates autophagy in osteoblasts via the miR-1252-5p/GNB1 axis in osteoporosis.
Title: PAX8-AS1 knockdown facilitates cell growth and inactivates autophagy in osteoblasts via the miR-1252-5p/GNB1 axis in osteoporosis.
G-protein betagamma subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity.
Title: G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity.
AGS3 and G betagamma are hypothesized to gate the uncontrolled motivation to seek EtOH during abstinence
Title: Nucleus accumbens AGS3 expression drives ethanol seeking through G betagamma.
A2A-receptors couple to G(salpha) subunits which is essential for facilitation to occur, also involving G(i/o)-protein coupling and/or G(betagamma) subunits (anti-G(betagamma).
Title: A2A adenosine-receptor-mediated facilitation of noradrenaline release in rat tail artery involves protein kinase C activation and betagamma subunits formed after alpha2-adrenoceptor activation.
G betagamma binds HDAC5 and inhibits its transcriptional co-repression activity
Title: G betagamma binds histone deacetylase 5 (HDAC5) and inhibits its transcriptional co-repression activity.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:496680 (e-PCR)
- UniSTS:496680

Gnb1 (e-PCR), detects polymorphism
- UniSTS:496680

RH127715 (e-PCR)
- UniSTS:211025

RH124831 (e-PCR)
- UniSTS:161653

RH140264 (e-PCR)
- UniSTS:222342

AA900898 (e-PCR)
- UniSTS:226203

PMC197251P1 (e-PCR)
- UniSTS:271850

BE099765 (e-PCR)
- UniSTS:245748

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables alkylglycerophosphoethanolamine phosphodiesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor complex adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables spectrin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cardiac muscle cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of taste	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of heterotrimeric G-protein complex	ISO Inferred from Sequence Orthology more info
part_of heterotrimeric G-protein complex	TAS Traceable Author Statement more info	PubMed
located_in photoreceptor inner segment	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info
located_in photoreceptor outer segment membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Names: Guanine nucleotide-binding protein beta 1; guanine nucleotide binding protein (G protein), beta 1; guanine nucleotide binding protein (G protein), beta polypeptide 1; guanine nucleotide binding protein, beta 1; guanine nucleotide-binding protein, beta-1 subunit; transducin beta chain 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030987.2 → NP_112249.2 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

See identical proteins and their annotated locations for NP_112249.2

Status: PROVISIONAL

Source sequence(s)

BC078809

UniProtKB/Swiss-Prot

P54311, Q6Q8B1, Q9QWG8

UniProtKB/TrEMBL

A6IUQ6

Related

ENSRNOP00000044340.2, ENSRNOT00000041789.3

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

171357778..171424489

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287153.1 → XP_063143223.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

P54311, Q6Q8B1, Q9QWG8

UniProtKB/TrEMBL

A6IUQ6
XM_008764335.4 → XP_008762557.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

See identical proteins and their annotated locations for XP_008762557.1

UniProtKB/Swiss-Prot

P54311, Q6Q8B1, Q9QWG8

UniProtKB/TrEMBL

A6IUQ6

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]
XM_063287154.1 → XP_063143224.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

P54311, Q6Q8B1, Q9QWG8

UniProtKB/TrEMBL

A6IUQ6
XM_063287155.1 → XP_063143225.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

P54311, Q6Q8B1, Q9QWG8

UniProtKB/TrEMBL

A6IUQ6
XM_063287156.1 → XP_063143226.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

P54311, Q6Q8B1, Q9QWG8

UniProtKB/TrEMBL

A6IUQ6
XM_039109260.2 → XP_038965188.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

P54311, Q6Q8B1, Q9QWG8

UniProtKB/TrEMBL

A6IUQ6

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]
XM_006239517.5 → XP_006239579.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

See identical proteins and their annotated locations for XP_006239579.1

UniProtKB/Swiss-Prot

P54311, Q6Q8B1, Q9QWG8

UniProtKB/TrEMBL

A6IUQ6

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]
XM_039109261.2 → XP_038965189.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

P54311, Q6Q8B1, Q9QWG8

UniProtKB/TrEMBL

A6IUQ6

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]
XM_039109262.2 → XP_038965190.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

P54311, Q6Q8B1, Q9QWG8

UniProtKB/TrEMBL

A6IUQ6

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]
XM_039109263.2 → XP_038965191.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

P54311, Q6Q8B1, Q9QWG8

UniProtKB/TrEMBL

A6IUQ6

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]