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Gucy2f guanylate cyclase 2f [ Mus musculus (house mouse) ]

Gene ID: 245650, updated on 11-Apr-2024

Summary

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Official Symbol
Gucy2fprovided by MGI
Official Full Name
guanylate cyclase 2fprovided by MGI
Primary source
MGI:MGI:105119
See related
Ensembl:ENSMUSG00000042282 AllianceGenome:MGI:105119
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GC2; GC-F; A930002I06
Summary
Predicted to enable guanylate cyclase activity; identical protein binding activity; and peptide receptor activity. Involved in detection of light stimulus involved in visual perception. Located in rod photoreceptor outer segment. Is expressed in ear; inner ear; inner ear labyrinth; nervous system; and retina outer nuclear layer. Orthologous to human GUCY2F (guanylate cyclase 2F, retinal). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Gucy2f in Genome Data Viewer
Location:
X F2; X 62.85 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (140862282..140980399, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (142079286..142197276, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene 5762 Neighboring gene predicted gene 6373 Neighboring gene STARR-seq mESC enhancer starr_48017 Neighboring gene STARR-positive B cell enhancer mm9_chrX:138662261-138662562 Neighboring gene retinoblastoma binding protein 7 pseudogene Neighboring gene nuclear transport factor 2-like export factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors. Baehr W, et al. J Biol Chem, 2007 Mar 23. PMID 17255100, Free PMC Article
  2. Application of functional genomic technologies in a mouse model of retinal degeneration. Shearstone JR, et al. Genomics, 2005 Mar. PMID 15718098
  3. Guanylate cyclase-activating protein 2 contributes to phototransduction and light adaptation in mouse cone photoreceptors. Vinberg F, et al. J Biol Chem, 2018 May 11. PMID 29549122, Free PMC Article
  4. Esx1, a novel X chromosome-linked homeobox gene expressed in mouse extraembryonic tissues and male germ cells. Li Y, et al. Dev Biol, 1997 Aug 1. PMID 9245514
  5. Retinal guanylyl cyclase activation by calcium sensor proteins mediates photoreceptor degeneration in an rd3 mouse model of congenital human blindness. Dizhoor AM, et al. J Biol Chem, 2019 Sep 13. PMID 31346032, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. rd3 colocalizes and interacts with GC1 and GC2 in rod and cone photoreceptor cells of normal mice
    Title: RD3, the protein associated with Leber congenital amaurosis type 12, is required for guanylate cyclase trafficking in photoreceptor cells.
  2. guanylate cyclase 1 and guanylate cyclase 2 have roles in function of rod and cone photoreceptors
    Title: The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of light stimulus involved in visual perception IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in rod photoreceptor outer segment IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
retinal guanylyl cyclase 2
NP_001007577.1
XP_006528904.1
XP_036017858.1
XP_036017859.1
XP_036017860.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007576.2 → NP_001007577.1  retinal guanylyl cyclase 2 precursor

    See identical proteins and their annotated locations for NP_001007577.1

    Status: VALIDATED

    Source sequence(s)
    AK044234, AL671916, AY651761
    Consensus CDS
    CCDS30446.1
    UniProtKB/Swiss-Prot
    Q5SDA5, Q8BLL8
    Related
    ENSMUSP00000044521.4, ENSMUST00000042530.4
    Conserved Domains (4) summary
    smart00044
    Location:848 → 1040
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd06371
    Location:54 → 435
    PBP1_sensory_GC_DEF-like; ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
    pfam07701
    Location:824 → 869
    HNOBA; Heme NO binding associated
    cl21453
    Location:545 → 815
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    140862282..140980399 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161966.1 → XP_036017859.1  retinal guanylyl cyclase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5SDA5, Q8BLL8
    Conserved Domains (4) summary
    smart00044
    Location:848 → 1040
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd06371
    Location:54 → 435
    PBP1_sensory_GC_DEF-like; ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
    pfam07701
    Location:824 → 869
    HNOBA; Heme NO binding associated
    cl21453
    Location:545 → 815
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006528841.5 → XP_006528904.1  retinal guanylyl cyclase 2 isoform X1

    See identical proteins and their annotated locations for XP_006528904.1

    UniProtKB/Swiss-Prot
    Q5SDA5, Q8BLL8
    Conserved Domains (4) summary
    smart00044
    Location:848 → 1040
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd06371
    Location:54 → 435
    PBP1_sensory_GC_DEF-like; ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
    pfam07701
    Location:824 → 869
    HNOBA; Heme NO binding associated
    cl21453
    Location:545 → 815
    PKc_like; Protein Kinases, catalytic domain

  3. XM_036161965.1 → XP_036017858.1  retinal guanylyl cyclase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5SDA5, Q8BLL8
    Conserved Domains (4) summary
    smart00044
    Location:848 → 1040
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd06371
    Location:54 → 435
    PBP1_sensory_GC_DEF-like; ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
    pfam07701
    Location:824 → 869
    HNOBA; Heme NO binding associated
    cl21453
    Location:545 → 815
    PKc_like; Protein Kinases, catalytic domain

  4. XM_036161967.1 → XP_036017860.1  retinal guanylyl cyclase 2 isoform X2

    Conserved Domains (2) summary
    cd06371
    Location:54 → 435
    PBP1_sensory_GC_DEF-like; ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
    cl21453
    Location:545 → 708
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SDA5.1 GenPept UniProtKB/Swiss-Prot:Q5SDA5

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