ptgs2a prostaglandin-endoperoxide synthase 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptgs2aprovided by ZNC
Official Full Name: prostaglandin-endoperoxide synthase 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020530-2
See related: Ensembl:ENSDARG00000004539 AllianceGenome:ZFIN:ZDB-GENE-020530-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ptgs2; zCOX-2; fj02a10; unp1239; wu:fj02a10
Summary: Enables peroxidase activity. Acts upstream of or within animal organ development; cellular response to organic cyclic compound; and response to steroid hormone. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and neuron projection. Is expressed in several structures, including cardiovascular system; digestive system; endoderm; gonad; and head. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; arthritis (multiple); cardiovascular system disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human PTGS2 (prostaglandin-endoperoxide synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (20916497..20923864, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (21258435..21265802, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cyclooxygenase production of PGE2 promotes phagocyte control of A. fumigatus hyphal growth in larval zebrafish.
Title: Cyclooxygenase production of PGE2 promotes phagocyte control of A. fumigatus hyphal growth in larval zebrafish.
ptgs1-/- ptgs2a-/- double mutant female zebrafish were infertile due to ovulation failure; knockdown of ptgs2b in ptgs1-/- ptgs2a-/- double mutant embryos induced severe defects in the formation of connecting cilia and photoreceptor cell development
Title: Photoreceptor cell development requires prostaglandin signaling in the zebrafish retina.
Luteinizing hormone signaling induced ptgs2a expression is required for ovulation in zebrafish.
Title: LH signaling induced ptgs2a expression is required for ovulation in zebrafish.
Retinoic acid inhibits beta-catenin through suppression of Cox-2
Title: Retinoic acid inhibits beta-catenin through suppression of Cox-2: a role for truncated adenomatous polyposis coli.
Mutations in the APC gene resultt in impaired retinoic acid biosynthesis and upegulation of cox2.
Title: The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables peroxidase activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin-endoperoxide synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin-endoperoxide synthase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
involved_in cyclooxygenase pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prostaglandin G/H synthase 2a

Names: Cox-2a; cox2; prostaglandin-endoperoxide synthase 2

NP_705943.1

EC 1.14.99.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153657.1 → NP_705943.1 prostaglandin G/H synthase 2a precursor

See identical proteins and their annotated locations for NP_705943.1

Status: PROVISIONAL

Source sequence(s)

AY028585

UniProtKB/TrEMBL

Q8JH43

Related

ENSDARP00000022450.7, ENSDART00000006870.8

Conserved Domains (2) summary

cd09816
Location:78 → 559

prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins

cd00054
Location:25 → 58

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...