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ALOX15B arachidonate 15-lipoxygenase type B [ Homo sapiens (human) ]

Gene ID: 247, updated on 4-Jan-2025

Summary

Official Symbol
ALOX15Bprovided by HGNC
Official Full Name
arachidonate 15-lipoxygenase type Bprovided by HGNC
Primary source
HGNC:HGNC:434
See related
Ensembl:ENSG00000179593 MIM:603697; AllianceGenome:HGNC:434
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
15-LOX-2
Summary
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in prostate (RPKM 42.3), esophagus (RPKM 13.5) and 2 other tissues See more
Orthologs
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Genomic context

See ALOX15B in Genome Data Viewer
Location:
17p13.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (8039059..8049134)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7944477..7954568)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7942377..7952452)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene guanylate cyclase 2D, retinal Neighboring gene ReSE screen-validated silencer GRCh37_chr17:7920053-7920233 Neighboring gene uncharacterized LOC124904131 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:7960995-7961512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7967665-7968166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7972295-7972796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7976377-7976910 Neighboring gene arachidonate lipoxygenase 3 pseudogene 1 Neighboring gene arachidonate 12-lipoxygenase, 12R type Neighboring gene uncharacterized LOC107985075 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8149 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11660

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables arachidonate 15-lipoxygenase activity  
enables arachidonate 15-lipoxygenase activity PubMed 
enables arachidonate 8(S)-lipoxygenase activity  
enables calcium ion binding PubMed 
enables iron ion binding PubMed 
enables linoleate 13S-lipoxygenase activity PubMed 
enables linoleate 9S-lipoxygenase activity  
enables lipid binding  
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in apoptotic process PubMed 
involved_in arachidonate metabolic process  
involved_in arachidonate metabolic process PubMed 
involved_in cannabinoid biosynthetic process PubMed 
involved_in endocannabinoid signaling pathway PubMed 
involved_in hepoxilin biosynthetic process  
involved_in hepoxilin biosynthetic process  
involved_in linoleic acid metabolic process  
involved_in lipid metabolic process PubMed 
involved_in lipid metabolic process PubMed 
involved_in lipid oxidation  
involved_in lipoxin A4 biosynthetic process PubMed 
involved_in lipoxygenase pathway  
involved_in negative regulation of cell cycle PubMed 
involved_in negative regulation of cell migration PubMed 
involved_in negative regulation of cell population proliferation PubMed 
involved_in negative regulation of cell population proliferation PubMed 
involved_in negative regulation of growth PubMed 
involved_in phospholipid metabolic process PubMed 
involved_in positive regulation of chemokine production PubMed 
involved_in positive regulation of keratinocyte differentiation  
involved_in positive regulation of macrophage derived foam cell differentiation PubMed 
involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway  
involved_in prostate gland development PubMed 
involved_in regulation of epithelial cell differentiation PubMed 
Component Evidence Code Pubs
located_in adherens junction PubMed 
located_in cytoskeleton PubMed 
located_in cytosol PubMed 
located_in cytosol  
located_in extracellular exosome PubMed 
located_in focal adhesion PubMed 
located_in membrane PubMed 
NOT located_in nucleus PubMed 
located_in nucleus PubMed 
located_in nucleus  
located_in plasma membrane PubMed 

General protein information

Preferred Names
polyunsaturated fatty acid lipoxygenase ALOX15B
Names
15-LOX-B
15S-lipoxygenase
arachidonate 15-lipoxygenase 2
arachidonate 15-lipoxygenase type II
arachidonate 15-lipoxygenase, second type
arachidonate omega(6) lipoxygenase
linoleate 13-lipoxygenase 15-LOb
NP_001034219.1
NP_001034220.1
NP_001132.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029482.1 RefSeqGene

    Range
    5020..15095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039130.2NP_001034219.1  polyunsaturated fatty acid lipoxygenase ALOX15B isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) lacks an exon in the 3' coding region but maintains the reading frame, compared to variant d. The encoded isoform (a) is shorter than isoform d.
    Source sequence(s)
    AF468052, BC063647, BP327830, CA307212, CA405703
    Consensus CDS
    CCDS32558.1
    UniProtKB/TrEMBL
    A8K9R4
    Related
    ENSP00000369520.2, ENST00000380173.6
    Conserved Domains (2) summary
    cd01753
    Location:2121
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:232638
    Lipoxygenase; Lipoxygenase
  2. NM_001039131.2NP_001034220.1  polyunsaturated fatty acid lipoxygenase ALOX15B isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) has multiple differences in the coding region but maintains the reading frame, compared to variant d. The encoded isoform (b) is shorter than isoform d.
    Source sequence(s)
    AF468053, BC063647, BP327830, CA307212, CA405703
    Consensus CDS
    CCDS32559.1
    UniProtKB/TrEMBL
    I3L1D5
    Related
    ENSP00000460332.2, ENST00000573359.1
    Conserved Domains (2) summary
    cd01753
    Location:2121
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:232593
    Lipoxygenase; Lipoxygenase
  3. NM_001141.3NP_001132.2  polyunsaturated fatty acid lipoxygenase ALOX15B isoform d

    See identical proteins and their annotated locations for NP_001132.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) represents the longest transcript and encodes the longest isoform (d).
    Source sequence(s)
    AF468051, BC063647, BP327830, CA307212, CA405703
    Consensus CDS
    CCDS11128.1
    UniProtKB/Swiss-Prot
    D3DTR2, O15296, Q8IYQ2, Q8TEV3, Q8TEV4, Q8TEV5, Q8TEV6, Q9UKM4
    UniProtKB/TrEMBL
    A8K9R4
    Related
    ENSP00000369530.4, ENST00000380183.9
    Conserved Domains (2) summary
    cd01753
    Location:2121
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:232667
    Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    8039059..8049134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    7944477..7954568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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