Fcer1a Fc epsilon receptor Ia [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fcer1aprovided by RGD
Official Full Name: Fc epsilon receptor Iaprovided by RGD
Primary source: RGD:2597
See related: Ensembl:ENSRNOG00000009177 AllianceGenome:RGD:2597
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Iger01; RATIGER01
Summary: Predicted to enable IgE binding activity and IgE receptor activity. Predicted to be involved in cell surface receptor signaling pathway and regulation of immune response. Predicted to act upstream of or within several processes, including leukotriene biosynthetic process; positive regulation of immune response; and positive regulation of macromolecule metabolic process. Predicted to be located in external side of plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human FCER1A (Fc fragment of IgE receptor Ia). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 3.1), Lung (RPKM 2.5) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (88218427..88224723, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (85686099..85692394, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (91727253..91737106, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differential Ca(2+) mobilization and mast cell degranulation by FcepsilonRI- and GPCR-mediated signaling has been reported.
Title: Differential Ca(2+) mobilization and mast cell degranulation by FcεRI- and GPCR-mediated signaling.
This study reveals a complex regulation for PLSCR1 tyrosine phosphorylation in FcepsilonRI-activated mast cells, and that PLSCR1 sits at a crossroads between Lyn and Fyn pathways.
Title: Regulation of the tyrosine phosphorylation of Phospholipid Scramblase 1 in mast cells that are stimulated through the high-affinity IgE receptor.
Data suggest M2PK (M2-type pyruvate kinase) is modulated in mast cell degranulation via IgE/FCERI signaling; immediate inhibition of M2PK involves tyrosine phosphorylation; subsequently fructose-1,6-biphosphate accumulates and activates M2PK.
Title: Dual regulation of mast cell degranulation through IgE receptor-mediated modulation of M₂-type pyruvate kinase.
PTP-PEST expression was significantly induced upon FcepsilonRI-crosslinking, and aggregation of FcepsilonRI induced the phosphorylation of PTP-PEST at Ser39, thus resulting in the suppression of PTP activity.
Title: Protein tyrosine phosphatase-PEST (PTP-PEST) regulates mast cell-activating signals in PTP activity-dependent and -independent manners.
NK-1 receptor is required for the activation of RBL-2H3 cells following FcepsilonRIota engagement and involved in the regulation of mitogen-activated protein kinase signaling pathways
Title: An involvement of neurokinin-1 receptor in FcεRΙ-mediated RBL-2H3 mast cell activation.
results reveal intricate functional interactions among different cis-acting elements of IgE receptor in the transcriptional regulation of cox-2. Fyn-->PI 3-kinase-->Akt pathway directly stimulate
Title: Identification of cis-acting elements and signaling components of high affinity IgE receptor that regulate the expression of cyclooxygenase-2.
Data show that among expressed chemokines and cytokines, only CCL2, CCL7 and interleukin (IL)-6 were expressed at higher levels following FcepsilonRI-CCR1 costimulation.
Title: Identification of genes and proteins specifically regulated by costimulation of mast cell Fcε Receptor I and chemokine receptor 1.
These data suggest that CD84 may play a role in modulating Fc epsilon RI-mediated signaling in mast cells.
Title: The leukocyte receptor CD84 inhibits Fc epsilon RI-mediated signaling through homophilic interaction in transfected RBL-2H3 cells.
Data show that EGFR, via interaction with FcvarepsilonRI and integrin alpha(5), is necessary for allergic inflammation associated with cellular interaction.
Title: Integrin α(5) interacts with EGFR, is necessary for FcɛRI signaling and is necessary for allergic inflammation in relation with angiogenesis.
In an immunological model, although serial engagement is not required for rat mast cell signaling, it can influence recruitment of Syk kinase to the receptor and subsequent Syk phosphorylation.
Title: A detailed mathematical model predicts that serial engagement of IgE-Fc epsilon RI complexes can enhance Syk activation in mast cells.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:489127

D13Wox17 (e-PCR)
- UniSTS:517814

RH94548 (e-PCR)
- UniSTS:119796

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables IgE binding	IBA Inferred from Biological aspect of Ancestor more info
enables IgE binding	ISO Inferred from Sequence Orthology more info
enables IgE binding	TAS Traceable Author Statement more info	PubMed
enables IgE receptor activity	ISO Inferred from Sequence Orthology more info
enables high-affinity IgE receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables high-affinity IgE receptor activity	ISO Inferred from Sequence Orthology more info
enables high-affinity IgE receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in Fc-epsilon receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in eosinophil degranulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in immune response	TAS Traceable Author Statement more info	PubMed
involved_in immunoglobulin mediated immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within leukotriene biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in mast cell degranulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of granulocyte macrophage colony-stimulating factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-3 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mast cell cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mast cell degranulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type I hypersensitivity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within serotonin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info
involved_in type 2 immune response	ISO Inferred from Sequence Orthology more info
involved_in type I hypersensitivity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: high affinity immunoglobulin epsilon receptor subunit alpha

Names: Fc fragment of IgE receptor Ia; Fc fragment of IgE, high affinity I, receptor for; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; Fc receptor, IgE, high affinity I, alpha polypeptide; alpha polypeptide; fc-epsilon RI-alpha; fcERI; igE Fc receptor subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012724.4 → NP_036856.1 high affinity immunoglobulin epsilon receptor subunit alpha precursor

See identical proteins and their annotated locations for NP_036856.1

Status: PROVISIONAL

Source sequence(s)

J03606

UniProtKB/Swiss-Prot

P12371, P12840

UniProtKB/TrEMBL

F1LSQ5

Related

ENSRNOP00000092868.1, ENSRNOT00000104245.1

Conserved Domains (3) summary

cd05752
Location:28 → 106

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:110 → 192

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

smart00410
Location:34 → 106

IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

88218427..88224723 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090373.2 → XP_038946301.1 high affinity immunoglobulin epsilon receptor subunit alpha isoform X1

UniProtKB/TrEMBL

A0A0G2JV43, F1LSQ5

Related

ENSRNOP00000069343.2

Conserved Domains (2) summary

cd05752
Location:21 → 99

Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

cd05753
Location:103 → 185

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains