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Cd80 Cd80 molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 25408, updated on 3-Apr-2024

Summary

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Symbol
Cd80provided by RGD
Full Name
Cd80 moleculeprovided by RGD
Primary source
RGD:2314
See related
Ensembl:ENSRNOG00000001527 AllianceGenome:RGD:2314
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
B7-1
Summary
Predicted to enable coreceptor activity. Involved in positive regulation of T cell proliferation. Located in cell surface. Used to study adult T-cell leukemia; anti-basement membrane glomerulonephritis; high grade glioma; and periodontal disease. Biomarker of kidney failure. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human CD80 (CD80 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 25.4), Thymus (RPKM 23.2) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
11q21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (75760073..75798978, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (62254543..62293414, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (64815201..64855293, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene protein O-glucosyltransferase 1 Neighboring gene uncharacterized LOC103693581 Neighboring gene translocase of inner mitochondrial membrane domain containing 1 Neighboring gene uncharacterized LOC108352341 Neighboring gene ADP-ribosylarginine hydrolase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cholecystokinin octapeptide significantly suppresses collagen-induced arthritis in mice by inhibiting Th17 polarization primed by dendritic cells. Li Q, et al. Cell Immunol, 2011. PMID 22004797
  2. Clonorchis sinensis-derived total protein attenuates airway inflammation in murine asthma model by inducing regulatory T cells and modulating dendritic cell functions. Jeong YI, et al. Biochem Biophys Res Commun, 2011 Apr 22. PMID 21440530
  3. A soluble thymic stromal lymphopoietin (TSLP) antagonist, TSLPR-immunoglobulin, reduces the severity of allergic disease by regulating pulmonary dendritic cells. Zhang F, et al. Clin Exp Immunol, 2011 May. PMID 21352203, Free PMC Article
  4. Primed status of transitional B cells associated with their presence in the cerebrospinal fluid in early phases of multiple sclerosis. Lee-Chang C, et al. Clin Immunol, 2011 Apr. PMID 21310664
  5. Anti-allergic effects of Lactobacillus crispatus KT-11 strain on ovalbumin-sensitized BALB/c mice. Tobita K, et al. Anim Sci J, 2010 Dec. PMID 21108691

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Losartan Protects Podocytes against High Glucose-induced Injury by Inhibiting B7-1 Expression.
    Title: Losartan Protects Podocytes against High Glucose-induced Injury by Inhibiting B7-1 Expression.
  2. Diabetes-Mediated Toxicity Resulted in the Expression of CD80 and CD86 on Neutrophils after Delayed Wound Healing in Male Rats.
    Title: Diabetes-Mediated Toxicity Resulted in the Expression of CD80 and CD86 on Neutrophils after Delayed Wound Healing in Male Rats.
  3. ETRA antagonist restores podocyte foot process effacement as well as the aberrant expression of TLR-3, nuclear factor-kappaB (NF-kappaB), and CD80 in puromycin aminonucleoside-injured kidneys
    Title: Antiproteinuric effect of an endothelin-1 receptor antagonist in puromycin aminonucleoside-induced nephrosis in rat.
  4. Selective expression of B7-1 (CD80) is important and may serve as a guide for future therapies aimed at transplant tolerance.
    Title: HLA-G-treated tolerogenic dendritic cells induce tolerogenic potential by increasing expression of B7-1 (CD80) molecules.
  5. Blocking expression of B7.1 in donor spleens by antisense gene therapy represents a potential alloantigen-specific immunosuppressive strategy to inhibit acute rejection against splenic allografts.
    Title: Gene transfer of antisense B7.1 attenuates acute rejection against splenic allografts in rats.
  6. Upregulation of B7.1 with the downregulation of GLEPP1, Wilms' tumor gene (WT1), megalin, and vascular endothelial growth factor started early and persisted through the course of rimary glomerular disease.
    Title: Early changes in gene expression that influence the course of primary glomerular disease.
  7. B7.1 and B7.2 are expressed in the eye at different times during experimental autoimmune anterior uveitis. Both B7 molecules are required for the induction of EAAU, although they probably have different roles.
    Title: Expression of B7 molecules in the eye during experimental autoimmune anterior uveitis (EAAU).
  8. CTLA4Ig gene therapy is a successful strategy for the prevention of allogeneic graft rejection in corneal transplantation. Our work has further elucidated the mechanisms of corneal allograft rejection which may lead to novel therapeutic strategies.
    Title: Influence of local and systemic CTLA4Ig gene transfer on corneal allograft survival.
  9. Differential effect of CD28 versus B7 blockade on direct pathway of allorecognition and self-restricted responses.
    Title: Differential effect of CD28 versus B7 blockade on direct pathway of allorecognition and self-restricted responses.
  10. an inducible diabetes model in transgenic mice based on rat insulin promotor (RIP)-driven expression of CD80 (B7-1) on pancreatic beta cells.
    Title: Cytotoxic T cell-mediated diabetes in RIP-CD80 transgenic mice: autoantigen peptide sensitivity and fine specificity.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables coreceptor activity IEA
Inferred from Electronic Annotation
more info
  
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell costimulation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within T cell costimulation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of T cell mediated immunity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of alpha-beta T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein complex involved in cell adhesion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
T-lymphocyte activation antigen CD80
Names
CD80 antigen
CD80-like
Cd80 a rat homolog of the human CD28/CTLA - 4 ligand (B7-1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418663.2 → NP_001405592.1  T-lymphocyte activation antigen CD80 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A6IR66

  2. NM_012926.2 → NP_037058.2  T-lymphocyte activation antigen CD80 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A6IR66, O35187
    Conserved Domains (3) summary
    cd00096
    Location:41 → 46
    Ig; Ig strand A [structural motif]
    cd16083
    Location:147 → 237
    IgC1_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) 80; member of the C1-set of Ig superfamily (IgSF) domains
    cl11960
    Location:40 → 144
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    75760073..75798978 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088035.2 → XP_038943963.1  T-lymphocyte activation antigen CD80 isoform X1

    UniProtKB/TrEMBL
    G3V671, O35187
    Conserved Domains (3) summary
    cd00096
    Location:41 → 46
    Ig; Ig strand A [structural motif]
    cd16083
    Location:147 → 237
    IgC1_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) 80; member of the C1-set of Ig superfamily (IgSF) domains
    cl11960
    Location:40 → 144
    Ig; Immunoglobulin domain

  2. XM_039088036.2 → XP_038943964.1  T-lymphocyte activation antigen CD80 isoform X1

    UniProtKB/TrEMBL
    G3V671, O35187
    Related
    ENSRNOP00000002089.5
    Conserved Domains (3) summary
    cd00096
    Location:41 → 46
    Ig; Ig strand A [structural motif]
    cd16083
    Location:147 → 237
    IgC1_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) 80; member of the C1-set of Ig superfamily (IgSF) domains
    cl11960
    Location:40 → 144
    Ig; Immunoglobulin domain

  3. XM_063270308.1 → XP_063126378.1  T-lymphocyte activation antigen CD80 isoform X2

    UniProtKB/TrEMBL
    A6IR66

  4. XM_063270307.1 → XP_063126377.1  T-lymphocyte activation antigen CD80 isoform X1

    UniProtKB/TrEMBL
    G3V671

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001418662.1: Suppressed sequence

    Description
    NM_001418662.1: This RefSeq was removed because it is redundant with another Refseq.
Nucleotide Protein Strain
Heading Accession and Version

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