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Nog noggin [ Rattus norvegicus (Norway rat) ]

Gene ID: 25495, updated on 4-Jan-2025

Summary

Official Symbol
Nogprovided by RGD
Official Full Name
nogginprovided by RGD
Primary source
RGD:3183
See related
EnsemblRapid:ENSRNOG00000023683 AllianceGenome:RGD:3183
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cytokine binding activity and protein homodimerization activity. Involved in several processes, including cellular response to BMP stimulus; learning or memory; and regulation of gliogenesis. Located in axon and extracellular space. Part of protein-containing complex. Biomarker of acute kidney tubular necrosis and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Huntington's disease; bone disease (multiple); cleft lip; and hyperopia. Orthologous to human NOG (noggin). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Nog in Genome Data Viewer
Location:
10q26
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (74625874..74627501, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (74128712..74130339, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (76811759..76813386, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480709 Neighboring gene uncharacterized LOC120095173 Neighboring gene noggin like 1 Neighboring gene ankyrin-repeat and fibronectin type III domain containing 1 Neighboring gene uncharacterized LOC134480856 Neighboring gene uncharacterized LOC120095174

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine binding  
enables cytokine binding  
enables protein binding PubMed 
enables protein homodimerization activity  
enables protein homodimerization activity  
enables protein-containing complex binding PubMed 
Items 1 - 25 of 168
Process Evidence Code Pubs
involved_in BMP signaling pathway  
acts_upstream_of BMP signaling pathway  
involved_in BMP signaling pathway  
acts_upstream_of_or_within anatomical structure formation involved in morphogenesis  
involved_in atrial cardiac muscle tissue morphogenesis  
involved_in atrial cardiac muscle tissue morphogenesis  
involved_in axial mesoderm development  
acts_upstream_of_or_within axial mesoderm development  
acts_upstream_of_or_within axon guidance  
acts_upstream_of_or_within brain development  
involved_in cartilage development  
acts_upstream_of cartilage development  
involved_in cell differentiation in hindbrain  
involved_in cell differentiation in hindbrain  
involved_in cell population proliferation  
involved_in cellular response to BMP stimulus PubMed 
acts_upstream_of_or_within cellular response to BMP stimulus  
involved_in cellular response to hypoxia PubMed 
acts_upstream_of_or_within central nervous system development  
involved_in cranial skeletal system development  
involved_in cranial skeletal system development  
involved_in dorsal/ventral pattern formation  
involved_in dorsal/ventral pattern formation  
involved_in embryonic digit morphogenesis  
involved_in embryonic digit morphogenesis  
involved_in embryonic skeletal joint morphogenesis  
involved_in embryonic skeletal joint morphogenesis  
involved_in embryonic skeletal system development  
involved_in endocardial cushion formation  
involved_in endocardial cushion formation  
acts_upstream_of_or_within endoderm development  
involved_in endoderm formation  
acts_upstream_of_or_within endoderm formation  
involved_in epithelial cell proliferation  
acts_upstream_of epithelial cell proliferation  
involved_in epithelial to mesenchymal transition  
involved_in epithelial to mesenchymal transition  
involved_in epithelial to mesenchymal transition  
involved_in exploration behavior  
involved_in exploration behavior  
involved_in face morphogenesis  
acts_upstream_of_or_within face morphogenesis  
involved_in fibroblast growth factor receptor signaling pathway  
involved_in fibroblast growth factor receptor signaling pathway  
involved_in forebrain development PubMed 
involved_in forebrain development  
involved_in heart trabecula morphogenesis  
involved_in heart trabecula morphogenesis  
involved_in hippocampus development PubMed 
involved_in in utero embryonic development  
acts_upstream_of_or_within in utero embryonic development  
involved_in limb development  
involved_in long-term synaptic potentiation  
involved_in long-term synaptic potentiation  
involved_in lung morphogenesis  
acts_upstream_of_or_within lung morphogenesis  
involved_in membranous septum morphogenesis  
involved_in membranous septum morphogenesis  
involved_in memory PubMed 
involved_in mesenchymal cell differentiation PubMed 
acts_upstream_of_or_within mesenchymal cell differentiation  
involved_in mesoderm formation  
acts_upstream_of_or_within mesoderm formation  
involved_in middle ear morphogenesis  
involved_in middle ear morphogenesis  
involved_in motor neuron axon guidance  
acts_upstream_of_or_within motor neuron axon guidance  
involved_in negative regulation of BMP signaling pathway  
acts_upstream_of_or_within negative regulation of BMP signaling pathway  
involved_in negative regulation of BMP signaling pathway  
involved_in negative regulation of BMP signaling pathway  
involved_in negative regulation of SMAD protein signal transduction  
involved_in negative regulation of SMAD protein signal transduction  
involved_in negative regulation of apoptotic signaling pathway  
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway  
involved_in negative regulation of astrocyte differentiation  
involved_in negative regulation of astrocyte differentiation PubMed 
involved_in negative regulation of astrocyte differentiation  
involved_in negative regulation of astrocyte differentiation  
involved_in negative regulation of canonical Wnt signaling pathway  
involved_in negative regulation of canonical Wnt signaling pathway  
involved_in negative regulation of cardiac epithelial to mesenchymal transition  
involved_in negative regulation of cardiac epithelial to mesenchymal transition  
involved_in negative regulation of cardiac muscle cell proliferation  
involved_in negative regulation of cardiac muscle cell proliferation  
involved_in negative regulation of cardiac muscle cell proliferation  
involved_in negative regulation of cartilage development  
acts_upstream_of_or_within negative regulation of cartilage development  
involved_in negative regulation of cell migration  
involved_in negative regulation of cell migration  
involved_in negative regulation of cytokine activity  
involved_in negative regulation of gene expression  
acts_upstream_of_or_within negative regulation of gene expression  
involved_in negative regulation of osteoblast differentiation  
involved_in negative regulation of osteoblast differentiation  
involved_in negative regulation of transcription by RNA polymerase II  
involved_in negative regulation of transcription by RNA polymerase II  
involved_in neural plate anterior/posterior regionalization  
involved_in neural plate anterior/posterior regionalization  
involved_in neural plate morphogenesis  
acts_upstream_of_or_within neural plate morphogenesis  
involved_in neural tube closure  
acts_upstream_of_or_within neural tube closure  
acts_upstream_of_or_within neural tube development  
involved_in nodal signaling pathway  
involved_in nodal signaling pathway  
involved_in notochord morphogenesis  
acts_upstream_of_or_within notochord morphogenesis  
involved_in ossification PubMed 
involved_in osteoblast differentiation  
involved_in osteoblast differentiation  
involved_in osteoblast differentiation  
involved_in outflow tract morphogenesis  
involved_in outflow tract morphogenesis  
acts_upstream_of_or_within pattern specification process  
involved_in pharyngeal arch artery morphogenesis  
involved_in pharyngeal arch artery morphogenesis  
involved_in pituitary gland development  
acts_upstream_of_or_within pituitary gland development  
involved_in positive regulation of branching involved in ureteric bud morphogenesis  
involved_in positive regulation of branching involved in ureteric bud morphogenesis  
involved_in positive regulation of branching involved in ureteric bud morphogenesis  
involved_in positive regulation of cell population proliferation PubMed 
involved_in positive regulation of epithelial cell proliferation  
acts_upstream_of_or_within positive regulation of epithelial cell proliferation  
involved_in positive regulation of gene expression  
involved_in positive regulation of gene expression  
involved_in positive regulation of glomerulus development  
involved_in positive regulation of glomerulus development  
involved_in positive regulation of glomerulus development  
involved_in positive regulation of oligodendrocyte progenitor proliferation PubMed 
involved_in positive regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
involved_in presynaptic modulation of chemical synaptic transmission  
involved_in presynaptic modulation of chemical synaptic transmission  
involved_in prostatic bud formation  
acts_upstream_of_or_within prostatic bud formation  
acts_upstream_of_or_within regulation of BMP signaling pathway  
involved_in regulation of fibroblast growth factor receptor signaling pathway  
involved_in regulation of fibroblast growth factor receptor signaling pathway  
involved_in regulation of neuronal synaptic plasticity  
involved_in regulation of neuronal synaptic plasticity  
involved_in short-term synaptic potentiation  
involved_in short-term synaptic potentiation  
acts_upstream_of_or_within skeletal system development  
involved_in smoothened signaling pathway  
involved_in smoothened signaling pathway  
involved_in somatic stem cell population maintenance  
involved_in somatic stem cell population maintenance  
involved_in somite development  
acts_upstream_of_or_within somite development  
involved_in spinal cord development  
acts_upstream_of_or_within spinal cord development  
involved_in stem cell differentiation  
acts_upstream_of_or_within stem cell differentiation  
acts_upstream_of_or_within ureteric bud development  
involved_in ureteric bud formation  
involved_in ureteric bud formation  
acts_upstream_of_or_within urogenital system development  
involved_in ventricular compact myocardium morphogenesis  
involved_in ventricular compact myocardium morphogenesis  
involved_in ventricular septum morphogenesis  
involved_in visual learning  
involved_in visual learning PubMed 
involved_in visual learning  
involved_in wound healing  
involved_in wound healing  
involved_in wound healing  
Items 1 - 25 of 168
Component Evidence Code Pubs
located_in axon PubMed 
located_in extracellular space PubMed 
located_in extracellular space  
located_in extracellular space  
located_in presynapse  
part_of protein-containing complex PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012990.1 → NP_037122.1  noggin precursor

    See identical proteins and their annotated locations for NP_037122.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HI02, G3V8X8
    Related
    ENSRNOP00000030212.3, ENSRNOT00000032388.6
    Conserved Domains (1) summary
    pfam05806
    Location:12 → 232
    Noggin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    74625874..74627501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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