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DHRS7B dehydrogenase/reductase 7B [ Homo sapiens (human) ]

Gene ID: 25979, updated on 5-Mar-2024

Summary

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Official Symbol
DHRS7Bprovided by HGNC
Official Full Name
dehydrogenase/reductase 7Bprovided by HGNC
Primary source
HGNC:HGNC:24547
See related
Ensembl:ENSG00000109016 MIM:616160; AllianceGenome:HGNC:24547
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-93; SDR32C1
Summary
Predicted to enable DNA-binding transcription factor binding activity and transcription corepressor activity. Predicted to be involved in neutrophil differentiation. Predicted to act upstream of or within several processes, including brown fat cell differentiation; phosphatidylcholine biosynthetic process; and regulation of cold-induced thermogenesis. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 7.1), thyroid (RPKM 6.1) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
17p11.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (21126964..21191420)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (21068745..21140297)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (21030277..21094733)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900389 Neighboring gene ubiquitin specific peptidase 22 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:20937215-20937716 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8311 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:20946145-20947094 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:20947095-20948042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:20954728-20955314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11877 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:20970211-20970711 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:20978550-20979050 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:20987896-20989095 Neighboring gene long intergenic non-protein coding RNA 1563 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr17:21002173-21002789 and GRCh37_chr17:21002790-21003407 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:21011664-21012527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11879 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:21102215-21103012 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:21108419-21109051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11880 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8313 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11881 Neighboring gene transmembrane protein 11 Neighboring gene TMEM11 divergent transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. Evans DM, et al. Hum Mol Genet, 2013 Oct 1. PMID 23720494, Free PMC Article
  2. WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ΔNp73 levels. Chaudhary N, et al. Mol Cell Biol, 2014 Oct 1. PMID 25071155, Free PMC Article
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Lai CH, et al. Genome Res, 2000 May. PMID 10810093, Free PMC Article
  4. High Throughput Chemical Screening Reveals Multiple Regulatory Proteins on FOXA1 in Breast Cancer Cell Lines. Wang S, et al. Int J Mol Sci, 2018 Dec 19. PMID 30572598, Free PMC Article
  5. Rho-associated protein kinase-dependent moesin phosphorylation is required for PD-L1 stabilization in breast cancer. Meng F, et al. Mol Oncol, 2020 Nov. PMID 32941674, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC8916, FLJ42061, FLJ99908, DKFZp566O084

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
  
enables acylglycerone-phosphate reductase activity TAS
Traceable Author Statement
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adipose tissue development IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in ether lipid biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in neutrophil differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylcholine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cold-induced thermogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisomal membrane TAS
Traceable Author Statement
more info
  
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dehydrogenase/reductase SDR family member 7B
Names
dehydrogenase/reductase (SDR family) member 7B
short-chain dehydrogenase/reductase family 32C member 1
NP_001317088.1
NP_001380586.1
NP_001380587.1
NP_001380588.1
NP_001380589.1
NP_056325.2
XP_011522088.1
XP_024306453.1
XP_047291678.1
XP_047291679.1
XP_047291680.1
XP_047291681.1
XP_054171637.1
XP_054171638.1
XP_054171639.1
XP_054171640.1
XP_054171641.1
XP_054171642.1
XP_054171643.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330159.3 → NP_001317088.1  dehydrogenase/reductase SDR family member 7B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087393
    Consensus CDS
    CCDS82092.1
    UniProtKB/TrEMBL
    A0A0C4DGQ8
    Related
    ENSP00000468585.1, ENST00000579303.5

  2. NM_001393657.1 → NP_001380586.1  dehydrogenase/reductase SDR family member 7B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087393
    Conserved Domains (1) summary
    cd05332
    Location:50 → 309
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

  3. NM_001393658.1 → NP_001380587.1  dehydrogenase/reductase SDR family member 7B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC087393
    Conserved Domains (1) summary
    cd05332
    Location:50 → 307
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

  4. NM_001393659.1 → NP_001380588.1  dehydrogenase/reductase SDR family member 7B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC087393
    Conserved Domains (1) summary
    cl21454
    Location:50 → 260
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  5. NM_001393660.1 → NP_001380589.1  dehydrogenase/reductase SDR family member 7B isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC087393
    Conserved Domains (1) summary
    cd05332
    Location:50 → 260
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

  6. NM_015510.5 → NP_056325.2  dehydrogenase/reductase SDR family member 7B isoform 1

    See identical proteins and their annotated locations for NP_056325.2

    Status: VALIDATED

    Source sequence(s)
    AC087393
    Consensus CDS
    CCDS11215.1
    UniProtKB/Swiss-Prot
    B5MEF4, Q6IAN0, Q6UX59, Q9BTF9, Q9UFM6, Q9Y3A1
    Related
    ENSP00000378887.3, ENST00000395511.8
    Conserved Domains (1) summary
    cd05332
    Location:50 → 311
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    21126964..21191420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435722.1 → XP_047291678.1  dehydrogenase/reductase SDR family member 7B isoform X1

  2. XM_011523786.3 → XP_011522088.1  dehydrogenase/reductase SDR family member 7B isoform X4

    Conserved Domains (2) summary
    cd05332
    Location:97 → 304
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
    pfam00106
    Location:101 → 294
    adh_short; short chain dehydrogenase

  3. XM_024450685.2 → XP_024306453.1  dehydrogenase/reductase SDR family member 7B isoform X6

    Conserved Domains (1) summary
    cd05332
    Location:50 → 257
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

  4. XM_047435724.1 → XP_047291680.1  dehydrogenase/reductase SDR family member 7B isoform X3

  5. XM_047435723.1 → XP_047291679.1  dehydrogenase/reductase SDR family member 7B isoform X2

  6. XM_047435725.1 → XP_047291681.1  dehydrogenase/reductase SDR family member 7B isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    21068745..21140297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315667.1 → XP_054171642.1  dehydrogenase/reductase SDR family member 7B isoform X7

    UniProtKB/Swiss-Prot
    B5MEF4, Q6IAN0, Q6UX59, Q9BTF9, Q9UFM6, Q9Y3A1

  2. XM_054315662.1 → XP_054171637.1  dehydrogenase/reductase SDR family member 7B isoform X1

  3. XM_054315665.1 → XP_054171640.1  dehydrogenase/reductase SDR family member 7B isoform X4

  4. XM_054315668.1 → XP_054171643.1  dehydrogenase/reductase SDR family member 7B isoform X6

  5. XM_054315664.1 → XP_054171639.1  dehydrogenase/reductase SDR family member 7B isoform X3

  6. XM_054315663.1 → XP_054171638.1  dehydrogenase/reductase SDR family member 7B isoform X2

  7. XM_054315666.1 → XP_054171641.1  dehydrogenase/reductase SDR family member 7B isoform X5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001393656.1: Suppressed sequence

    Description
    NM_001393656.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IAN0.2 GenPept UniProtKB/Swiss-Prot:Q6IAN0

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