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RGS22 regulator of G protein signaling 22 [ Homo sapiens (human) ]

Gene ID: 26166, updated on 3-Apr-2024

Summary

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Official Symbol
RGS22provided by HGNC
Official Full Name
regulator of G protein signaling 22provided by HGNC
Primary source
HGNC:HGNC:24499
See related
Ensembl:ENSG00000132554 MIM:615650; AllianceGenome:HGNC:24499
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT145; PRTD-NY2
Summary
Enables G-protein alpha-subunit binding activity. Predicted to be involved in negative regulation of signal transduction. Located in actin cytoskeleton; cytosol; and fibrillar center. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 35.2), ovary (RPKM 3.9) and 1 other tissue See more
Orthologs
mouse all
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Genomic context

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Location:
8q22.2
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (99960936..100106049, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (101085830..101230841, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (100973164..101118277, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 13 homolog B Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:100782591-100783790 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 1 pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:100871617-100872116 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:100880771-100881278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:100883624-100884124 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:100904777-100905425 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:100905426-100906073 Neighboring gene MPRA-validated peak7123 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr8:100947244-100947479 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:100955411-100956610 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:100959374-100959874 Neighboring gene cytochrome c oxidase subunit 6C Neighboring gene small nucleolar RNA, C/D box 77B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27684 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19407 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19408 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:101162699-101163202 Neighboring gene F-box protein 43 Neighboring gene RNA polymerase II, I and III subunit K

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RGS22, a novel cancer/testis antigen, inhibits epithelial cell invasion and metastasis. Hu Y, et al. Clin Exp Metastasis, 2011 Aug. PMID 21533872
  2. miR-1260b promotes cell migration and invasion of hepatocellular carcinoma by targeting the regulator of G-protein signaling 22. Li X, et al. Biotechnol Lett, 2018 Jan. PMID 29038925
  3. RGS22 inhibits pancreatic adenocarcinoma cell migration through the G12/13 α subunit/F-actin pathway. Hu Y, et al. Oncol Rep, 2015 Nov. PMID 26323264
  4. RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits. Hu Y, et al. Biol Reprod, 2008 Dec. PMID 18703424
  5. Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma. Stacey SN, et al. Hum Mol Genet, 2014 Jun 1. PMID 24403052, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulator of G-protein signaling 22 (RGS22) was identified as a direct target of miR-1260b and was inhibited by miR-1260b. Knockdown of RGS22 increased proliferation of hepatocellular carcinoma cells.
    Title: miR-1260b promotes cell migration and invasion of hepatocellular carcinoma by targeting the regulator of G-protein signaling 22.
  2. RGS22 acts as a tumor suppressor, repressing human pancreatic adenocarcinoma cell migration by coupling to GNA12/13.
    Title: RGS22 inhibits pancreatic adenocarcinoma cell migration through the G12/13 α subunit/F-actin pathway.
  3. New basal cell carcinoma susceptibility loci were identified at TGM3 (rs214782) and RGS22(rs7006527).
    Title: Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.
  4. Over-expression of RGS22 in a highly metastatic esophageal cancer cell line causes decrease in cell migration and reduction in the invasive potential of the cells.
    Title: RGS22, a novel cancer/testis antigen, inhibits epithelial cell invasion and metastasis.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.
  6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  7. RGS22 may also play a role in GNA13 translocation from the cytoplasm to the nucleus during spermiogenesis
    Title: RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ40080, FLJ75004, MGC102908, DKFZp434I092

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G-protein alpha-subunit binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in fibrillar center IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
regulator of G-protein signaling 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286692.2 → NP_001273621.1  regulator of G-protein signaling 22 isoform 2

    See identical proteins and their annotated locations for NP_001273621.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK292559, AP005356, BC092411, BM684810
    Consensus CDS
    CCDS69521.1
    UniProtKB/Swiss-Prot
    Q8NE09
    Related
    ENSP00000428212.1, ENST00000523437.5
    Conserved Domains (3) summary
    cd08725
    Location:1014 → 1136
    RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
    cd08726
    Location:841 → 970
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cd08727
    Location:658 → 773
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2

  2. NM_001286693.2 → NP_001273622.1  regulator of G-protein signaling 22 isoform 3

    See identical proteins and their annotated locations for NP_001273622.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC021590, AP005356, BC050053, BM684810
    Consensus CDS
    CCDS75775.1
    UniProtKB/TrEMBL
    G3V112
    Related
    ENSP00000429382.1, ENST00000523287.5
    Conserved Domains (3) summary
    cd08725
    Location:845 → 967
    RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
    cd08726
    Location:672 → 801
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cd08727
    Location:489 → 604
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2

  3. NM_015668.5 → NP_056483.3  regulator of G-protein signaling 22 isoform 1

    See identical proteins and their annotated locations for NP_056483.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC021590, AP005356, BC036665, BM684810
    Consensus CDS
    CCDS43758.1
    UniProtKB/Swiss-Prot
    A8K944, Q569L2, Q86Y71, Q8NE09, Q9BYZ4, Q9UFN6
    Related
    ENSP00000354109.6, ENST00000360863.11
    Conserved Domains (3) summary
    cd08725
    Location:1026 → 1148
    RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
    cd08726
    Location:853 → 982
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cd08727
    Location:670 → 785
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    99960936..100106049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013310.3 → XP_016868799.1  regulator of G-protein signaling 22 isoform X7

  2. XM_017013309.3 → XP_016868798.1  regulator of G-protein signaling 22 isoform X5

  3. XM_005250856.4 → XP_005250913.1  regulator of G-protein signaling 22 isoform X2

    Conserved Domains (3) summary
    cd08725
    Location:973 → 1095
    RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
    cd08727
    Location:670 → 785
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
    cl02565
    Location:853 → 931
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  4. XM_047421681.1 → XP_047277637.1  regulator of G-protein signaling 22 isoform X6

  5. XM_005250858.4 → XP_005250915.1  regulator of G-protein signaling 22 isoform X3

    Conserved Domains (3) summary
    cd08726
    Location:853 → 982
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cd08727
    Location:670 → 785
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
    cl02565
    Location:1005 → 1094
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  6. XM_005250857.4 → XP_005250914.1  regulator of G-protein signaling 22 isoform X1

    Conserved Domains (3) summary
    cd08726
    Location:853 → 982
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cd08727
    Location:670 → 785
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
    cl02565
    Location:1026 → 1120
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  7. XM_047421679.1 → XP_047277635.1  regulator of G-protein signaling 22 isoform X4

  8. XM_017013311.2 → XP_016868800.1  regulator of G-protein signaling 22 isoform X9

    UniProtKB/TrEMBL
    B3KUK3

  9. XM_024447121.2 → XP_024302889.1  regulator of G-protein signaling 22 isoform X11

    UniProtKB/TrEMBL
    B3KUK3
    Related
    ENST00000517769.5
    Conserved Domains (3) summary
    cd08725
    Location:415 → 537
    RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
    cd08726
    Location:242 → 371
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cd08727
    Location:59 → 174
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2

  10. XM_005250860.4 → XP_005250917.1  regulator of G-protein signaling 22 isoform X8

    UniProtKB/TrEMBL
    B4DYK1
    Conserved Domains (1) summary
    cd08727
    Location:670 → 785
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2

  11. XM_047421682.1 → XP_047277638.1  regulator of G-protein signaling 22 isoform X12

  12. XM_011516959.4 → XP_011515261.1  regulator of G-protein signaling 22 isoform X10

    Conserved Domains (1) summary
    cl02565
    Location:670 → 722
    RGS; Regulator of G protein signaling (RGS) domain superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    101085830..101230841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360268.1 → XP_054216243.1  regulator of G-protein signaling 22 isoform X7

  2. XM_054360266.1 → XP_054216241.1  regulator of G-protein signaling 22 isoform X5

  3. XM_054360263.1 → XP_054216238.1  regulator of G-protein signaling 22 isoform X2

  4. XM_054360267.1 → XP_054216242.1  regulator of G-protein signaling 22 isoform X6

  5. XM_054360264.1 → XP_054216239.1  regulator of G-protein signaling 22 isoform X3

  6. XM_054360262.1 → XP_054216237.1  regulator of G-protein signaling 22 isoform X1

  7. XM_054360265.1 → XP_054216240.1  regulator of G-protein signaling 22 isoform X4

  8. XM_054360270.1 → XP_054216245.1  regulator of G-protein signaling 22 isoform X9

  9. XM_054360272.1 → XP_054216247.1  regulator of G-protein signaling 22 isoform X11

  10. XM_054360269.1 → XP_054216244.1  regulator of G-protein signaling 22 isoform X8

  11. XM_054360273.1 → XP_054216248.1  regulator of G-protein signaling 22 isoform X12

  12. XM_054360271.1 → XP_054216246.1  regulator of G-protein signaling 22 isoform X10

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NE09.3 GenPept UniProtKB/Swiss-Prot:Q8NE09

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