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GAS6 growth arrest specific 6 [ Homo sapiens (human) ]

Gene ID: 2621, updated on 4-Jan-2025

Summary

Official Symbol
GAS6provided by HGNC
Official Full Name
growth arrest specific 6provided by HGNC
Primary source
HGNC:HGNC:4168
See related
Ensembl:ENSG00000183087 MIM:600441; AllianceGenome:HGNC:4168
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AXSF; AXLLG
Summary
This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]
Expression
Ubiquitous expression in lung (RPKM 64.9), endometrium (RPKM 57.7) and 24 other tissues See more
Orthologs
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Genomic context

See GAS6 in Genome Data Viewer
Location:
13q34
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (113820549..113864076, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (113029283..113074357, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (114523522..114567049, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene basic salivary proline-rich protein 4-like Neighboring gene ReSE screen-validated silencer GRCh37_chr13:114456174-114456392 Neighboring gene long intergenic non-protein coding RNA 552 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114461359-114461860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114462417-114462918 Neighboring gene transmembrane protein 255B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114491163-114491692 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114491693-114492221 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114504133-114505007 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114506713-114507271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8040 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8041 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8042 Neighboring gene uncharacterized LOC124903220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114523566-114524115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114524665-114525213 Neighboring gene GAS6 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8043 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114540573-114541125 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114541680-114542232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114542404-114542980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114551447-114552070 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114552071-114552692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114555417-114555918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114555919-114556418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114556794-114557508 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114557509-114558222 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114563503-114564094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5551 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114566463-114567054 Neighboring gene GAS6 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114576933-114577480 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114577481-114578027 Neighboring gene long intergenic non-protein coding RNA 454

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ34709, DKFZp666G247

Gene Ontology Provided by GOA

Items 1 - 25 of 59
Process Evidence Code Pubs
involved_in B cell chemotaxis PubMed 
involved_in activation of protein kinase B activity  
involved_in animal organ regeneration  
involved_in apoptotic cell clearance PubMed 
involved_in blood coagulation  
involved_in calcium ion transmembrane transport PubMed 
involved_in cell surface receptor signaling pathway PubMed 
involved_in cell-substrate adhesion  
involved_in cellular response to glucose stimulus  
involved_in cellular response to growth factor stimulus  
involved_in cellular response to interferon-alpha PubMed 
involved_in cellular response to starvation  
involved_in cellular response to vitamin K PubMed 
involved_in cellular response to xenobiotic stimulus PubMed 
involved_in dendritic cell differentiation PubMed 
involved_in enzyme-linked receptor protein signaling pathway  
involved_in extracellular matrix assembly  
involved_in fibroblast apoptotic process  
involved_in fusion of virus membrane with host plasma membrane PubMed 
involved_in hematopoietic stem cell migration to bone marrow PubMed 
involved_in myeloid cell apoptotic process  
involved_in negative regulation of DNA-templated transcription PubMed 
involved_in negative regulation of apoptotic process PubMed 
involved_in negative regulation of biomineral tissue development PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity PubMed 
involved_in negative regulation of dendritic cell apoptotic process PubMed 
involved_in negative regulation of endothelial cell apoptotic process PubMed 
involved_in negative regulation of fibroblast apoptotic process PubMed 
involved_in negative regulation of interleukin-1 production PubMed 
involved_in negative regulation of interleukin-6 production PubMed 
involved_in negative regulation of myeloid cell apoptotic process  
involved_in negative regulation of oligodendrocyte apoptotic process PubMed 
involved_in negative regulation of renal albumin absorption  
involved_in negative regulation of tumor necrosis factor production PubMed 
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway PubMed 
involved_in negative regulation of type II interferon production PubMed 
involved_in neuron migration  
involved_in phagocytosis PubMed 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade PubMed 
involved_in positive regulation of TOR signaling  
involved_in positive regulation of cytokine-mediated signaling pathway PubMed 
involved_in positive regulation of dendritic cell chemotaxis PubMed 
acts_upstream_of_or_within positive regulation of fibroblast proliferation PubMed 
involved_in positive regulation of fibroblast proliferation PubMed 
involved_in positive regulation of gene expression PubMed 
involved_in positive regulation of glomerular filtration  
involved_in positive regulation of natural killer cell differentiation PubMed 
involved_in positive regulation of phagocytosis PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
involved_in positive regulation of protein export from nucleus PubMed 
involved_in positive regulation of protein kinase activity PubMed 
involved_in positive regulation of protein phosphorylation PubMed 
involved_in positive regulation of protein phosphorylation  
involved_in protein localization to plasma membrane PubMed 
involved_in protein phosphorylation PubMed 
involved_in receptor-mediated virion attachment to host cell PubMed 
involved_in signal transduction PubMed 
involved_in symbiont entry into host cell PubMed 
involved_in viral genome replication PubMed 
Items 1 - 25 of 59
Component Evidence Code Pubs
located_in Golgi lumen  
located_in cytoplasm PubMed 
located_in endoplasmic reticulum lumen  
located_in extracellular exosome PubMed 
located_in extracellular region  
located_in extracellular space PubMed 
located_in platelet alpha granule lumen  

General protein information

Preferred Names
growth arrest-specific protein 6
Names
AXL receptor tyrosine kinase ligand
AXL stimulatory factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029703.1 RefSeqGene

    Range
    4998..48525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000820.4NP_000811.1  growth arrest-specific protein 6 precursor

    See identical proteins and their annotated locations for NP_000811.1

    Status: REVIEWED

    Source sequence(s)
    AA045119, BC038984, HY038614
    Consensus CDS
    CCDS45072.1
    UniProtKB/Swiss-Prot
    B3KRQ7, B3KVL4, E9PBL7, Q14393, Q6IMN1, Q7Z7N3
    Related
    ENSP00000331831.6, ENST00000327773.7
    Conserved Domains (7) summary
    smart00179
    Location:197227
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:118153
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:298450
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00594
    Location:5392
    Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
    pfam02210
    Location:513651
    Laminin_G_2; Laminin G domain
    pfam14670
    Location:160195
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:232273
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    113820549..113864076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    113029283..113074357 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374422.1XP_054230397.1  growth arrest-specific protein 6 isoform X1

    UniProtKB/TrEMBL
    B4DZY7

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