Avpr1b arginine vasopressin receptor 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Avpr1bprovided by MGI
Official Full Name: arginine vasopressin receptor 1Bprovided by MGI
Primary source: MGI:MGI:1347010
See related: Ensembl:ENSMUSG00000026432 AllianceGenome:MGI:1347010
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: VIBR; VPR3; AVPR3; V3/V1b; AVPR V3; AVPR V1b
Summary: Predicted to enable peptide binding activity and vasopressin receptor activity. Involved in multicellular organism aging and regulation of blood pressure. Acts upstream of or within regulation of systemic arterial blood pressure by vasopressin. Predicted to be located in Golgi apparatus and plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in autism spectrum disorder; bipolar disorder; and mood disorder. Orthologous to human AVPR1B (arginine vasopressin receptor 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 57.09 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (131526908..131539740)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (131599114..131612000)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor.
Title: Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor.
No difference between wild-type (WT) and v1a and v1b double knockout (dKO) mice was found in olfactory preferences for estrous female odor to male odor. Over all four mating tests, the number of mounts and pursuits after receptive females was significantly greater in dKO mice than in WT mice. In the elevated plus maze and the open field test, dKO mice showed lower anxiety-like behavior than WT mice.
Title: Modulation of male mouse sociosexual and anxiety-like behaviors by vasopressin receptors.
These findings indicate that inhibition of mu-opioid-receptor-associated V1bR provides an approach for enhancing morphine analgesia without increasing analgesic tolerance
Title: Complex formation between the vasopressin 1b receptor, β-arrestin-2, and the μ-opioid receptor underlies morphine tolerance.
Data indicate the upregulation of vasopressin receptor 1 (V1R) expression on hepatocytes upon liver ischemia-reperfusion injury (IRI).
Title: Signaling through hepatocyte vasopressin receptor 1 protects mouse liver from ischemia-reperfusion injury.
Data identify specific brain areas that may be a part of a neural circuit that includes Avpr1b-expressing cells in the CA2 region of the hippocampus. It is thought that this circuit, when working properly, plays a role in how an animal evaluates its social context.
Title: Genotypic differences in intruder-evoked immediate early gene activation in male, but not female, vasopressin 1b receptor knockout mice.
Data show that cryptochrome Cry1 and Cry2 expression must be circadian and appropriately phased to support rhythms, and arginine vasopressin (AVP) receptor signaling is required to impose circuit-level circadian function.
Title: Rhythmic expression of cryptochrome induces the circadian clock of arrhythmic suprachiasmatic nuclei through arginine vasopressin signaling.
The data of this study indicate that the hippocampal CA2 is important for attacking in response to a male intruder and that the Avpr1b, likely through its role in regulating CA2 synaptic plasticity, is a necessary mediator
Title: Role of the vasopressin 1b receptor in rodent aggressive behavior and synaptic plasticity in hippocampal area CA2.
this study found that circadian rhythms of behavior (locomotor activity), clock gene expression, and body temperature immediately reentrained to phase-shifted light-dark cycles in mice lacking vasopressin receptors V1a and V1b (V1a(-/-)V1b(-/-)).
Title: Mice genetically deficient in vasopressin V1a and V1b receptors are resistant to jet lag.
vasopressin V1b receptor is involved in the mediation of anxious behavior of animals but is not involved in the mechanism underlying the influence of negative psychoemotional state on Lewis lung carcinoma metastasis
Title: Effect of vasopressin V1b receptor antagonist, SSR149415, on anxiety-like behavior and Lewis lung carcinoma metastasis in mice.
distribution and functional studies of the Avpr1b have established its major role in the pituitary where it plays a pivotal part in the regulation of the HPA response to stress, and in particular to acute stress[review]
Title: The vasopressin Avpr1b receptor: molecular and pharmacological studies.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:495977 (e-PCR)
- UniSTS:495977

Avpr1b (e-PCR), detects polymorphism
- UniSTS:495977

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables peptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables vasopressin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables vasopressin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in activation of phospholipase C activity	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of arachidonic acid secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inositol phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of systemic arterial blood pressure by vasopressin	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of systemic arterial blood pressure by vasopressin	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in symbiont entry into host cell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: vasopressin V1b receptor

Names: V3/V1b pituitary vasopressin receptor; antidiuretic hormone receptor 1b; arginine vasopressin type 1b receptor; vasopressin V3 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011924.3 → NP_036054.1 vasopressin V1b receptor

See identical proteins and their annotated locations for NP_036054.1

Status: VALIDATED

Source sequence(s)

AC120217

Consensus CDS

CCDS35703.1

UniProtKB/Swiss-Prot

Q9WU02

UniProtKB/TrEMBL

Q9JLP2

Related

ENSMUSP00000027690.7, ENSMUST00000027690.7

Conserved Domains (3) summary

pfam00001
Location:51 → 335

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam08983
Location:359 → 408

DUF1856; Domain of unknown function (DUF1856)

cl21561
Location:41 → 184

7tm_4; Olfactory receptor