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Axl AXL receptor tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 26362, updated on 4-Jan-2025

Summary

Official Symbol
Axlprovided by MGI
Official Full Name
AXL receptor tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:1347244
See related
Ensembl:ENSMUSG00000002602 AllianceGenome:MGI:1347244
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ark; Ufo; Tyro7
Summary
Predicted to enable several functions, including phosphatidylinositol 3-kinase binding activity; phosphatidylserine binding activity; and virus receptor activity. Involved in negative regulation of apoptotic process and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of or within several processes, including negative regulation of cytokine production; nervous system development; and neutrophil clearance. Predicted to be located in several cellular components, including actin cytoskeleton; cell surface; and extracellular space. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and respiratory system. Used to study autoimmune disease. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human AXL (AXL receptor tyrosine kinase). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in ovary adult (RPKM 53.4), mammary gland adult (RPKM 42.5) and 28 other tissues See more
Orthologs
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Genomic context

See Axl in Genome Data Viewer
Location:
7 A3; 7 14.02 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (25455925..25488502, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25756500..25788924, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:26503991-26504174 Neighboring gene coiled-coil domain containing 97 Neighboring gene heterogeneous nuclear ribonucleoprotein U-like 1 Neighboring gene STARR-seq mESC enhancer starr_18313 Neighboring gene predicted gene, 29763 Neighboring gene cytochrome P450, family 2, subfamily s, polypeptide 1 Neighboring gene 60S ribosomal protein L37a pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 30
Function Evidence Code Pubs
enables ATP binding  
enables GPI-linked ephrin receptor activity  
enables boss receptor activity  
enables brain-derived neurotrophic factor receptor activity  
enables epidermal growth factor receptor activity  
enables fibroblast growth factor receptor activity  
enables hepatocyte growth factor receptor activity  
enables histone H2AXY142 kinase activity  
enables histone H3Y41 kinase activity  
enables insulin receptor activity  
enables insulin-like growth factor receptor activity  
enables macrophage colony-stimulating factor receptor activity  
enables myosin heavy chain binding  
enables myosin heavy chain binding  
enables phosphatidylinositol 3-kinase binding  
enables phosphatidylinositol 3-kinase binding  
enables phosphatidylserine binding  
enables phosphatidylserine binding  
enables placental growth factor receptor activity  
enables platelet-derived growth factor alpha-receptor activity  
enables platelet-derived growth factor beta-receptor activity  
enables protein binding PubMed 
enables protein tyrosine kinase activity  
enables protein tyrosine kinase collagen receptor activity  
enables stem cell factor receptor activity  
enables transmembrane receptor protein tyrosine kinase activity  
enables transmembrane-ephrin receptor activity  
enables vascular endothelial growth factor receptor activity  
enables virus receptor activity  
enables virus receptor activity  
Items 1 - 25 of 30
Items 1 - 25 of 91
Process Evidence Code Pubs
involved_in Kit signaling pathway  
involved_in animal organ regeneration  
acts_upstream_of_or_within apoptotic cell clearance PubMed 
involved_in apoptotic cell clearance PubMed 
acts_upstream_of_or_within apoptotic cell clearance PubMed 
acts_upstream_of apoptotic process PubMed 
acts_upstream_of_or_within blood vessel remodeling PubMed 
involved_in brain-derived neurotrophic factor receptor signaling pathway  
involved_in cell differentiation  
involved_in cell maturation  
involved_in cell migration  
involved_in cell surface receptor protein tyrosine kinase signaling pathway  
involved_in cellular response to hydrogen peroxide  
involved_in cellular response to hydrogen peroxide  
involved_in cellular response to interferon-alpha  
involved_in cellular response to interferon-alpha  
involved_in cellular response to lipopolysaccharide  
involved_in cellular response to lipopolysaccharide  
involved_in chromatin remodeling  
involved_in collagen-activated tyrosine kinase receptor signaling pathway  
involved_in dendritic cell differentiation  
acts_upstream_of_or_within enzyme-linked receptor protein signaling pathway PubMed 
involved_in ephrin receptor signaling pathway  
involved_in epidermal growth factor receptor signaling pathway  
acts_upstream_of_or_within erythrocyte homeostasis PubMed 
acts_upstream_of_or_within erythrocyte homeostasis PubMed 
acts_upstream_of_or_within establishment of localization in cell PubMed 
acts_upstream_of_or_within establishment of localization in cell PubMed 
involved_in fibroblast growth factor receptor signaling pathway  
acts_upstream_of_or_within forebrain cell migration PubMed 
involved_in hepatocyte growth factor receptor signaling pathway  
acts_upstream_of_or_within inflammatory response PubMed 
involved_in innate immune response  
involved_in insulin receptor signaling pathway  
involved_in insulin-like growth factor receptor signaling pathway  
acts_upstream_of lymphocyte activation PubMed 
involved_in macrophage colony-stimulating factor signaling pathway  
acts_upstream_of macrophage cytokine production PubMed 
involved_in multicellular organism development  
involved_in natural killer cell differentiation  
acts_upstream_of_or_within natural killer cell differentiation PubMed 
involved_in negative regulation of apoptotic process  
acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
involved_in negative regulation of apoptotic process PubMed 
involved_in negative regulation of apoptotic process  
acts_upstream_of_or_within negative regulation of cytokine production PubMed 
involved_in negative regulation of dendritic cell apoptotic process  
involved_in negative regulation of dendritic cell apoptotic process  
acts_upstream_of_or_within negative regulation of lymphocyte activation PubMed 
acts_upstream_of_or_within negative regulation of macrophage cytokine production PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process PubMed 
acts_upstream_of_or_within negative regulation of tumor necrosis factor production PubMed 
involved_in negative regulation of type II interferon production  
involved_in negative regulation of type II interferon production  
involved_in nervous system development  
acts_upstream_of neuron apoptotic process PubMed 
acts_upstream_of_or_within neuron migration PubMed 
acts_upstream_of_or_within neuron migration PubMed 
acts_upstream_of_or_within neutrophil clearance PubMed 
acts_upstream_of_or_within ovulation cycle PubMed 
involved_in phagocytosis  
acts_upstream_of_or_within phagocytosis PubMed 
involved_in phagocytosis  
involved_in platelet activation  
acts_upstream_of_or_within platelet activation PubMed 
involved_in platelet-derived growth factor receptor-alpha signaling pathway  
involved_in platelet-derived growth factor receptor-beta signaling pathway  
involved_in positive regulation of cytokine-mediated signaling pathway  
involved_in positive regulation of cytokine-mediated signaling pathway  
involved_in positive regulation of natural killer cell differentiation  
involved_in positive regulation of natural killer cell differentiation  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
involved_in positive regulation of pinocytosis  
involved_in positive regulation of pinocytosis  
involved_in positive regulation of viral life cycle  
involved_in positive regulation of viral life cycle  
involved_in response to axon injury  
acts_upstream_of_or_within secretion by cell PubMed 
acts_upstream_of_or_within spermatogenesis PubMed 
acts_upstream_of_or_within substrate adhesion-dependent cell spreading PubMed 
involved_in symbiont entry into host cell  
involved_in symbiont entry into host cell  
acts_upstream_of tumor necrosis factor production PubMed 
acts_upstream_of_or_within vagina development PubMed 
involved_in vascular endothelial growth factor receptor-1 signaling pathway  
involved_in vascular endothelial growth factor signaling pathway  
Items 1 - 25 of 91
Component Evidence Code Pubs
located_in actin cytoskeleton  
located_in actin cytoskeleton  
located_in cell surface  
located_in cell surface  
located_in extracellular space  
located_in extracellular space  
located_in intracellular membrane-bounded organelle  
located_in intracellular membrane-bounded organelle  
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
part_of receptor complex  

General protein information

Preferred Names
tyrosine-protein kinase receptor UFO
Names
adhesion-related kinase
ufo oncogene homolog
NP_001177903.1
NP_001177904.1
NP_033491.2
XP_006540052.1
XP_006540054.1
XP_006540055.1
XP_006540056.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190974.1NP_001177903.1  tyrosine-protein kinase receptor UFO isoform 2 precursor

    See identical proteins and their annotated locations for NP_001177903.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC119211, AC162614, AK033237, BC058230
    Consensus CDS
    CCDS57528.1
    UniProtKB/TrEMBL
    Q6PE80
    Related
    ENSMUSP00000083110.5, ENSMUST00000085948.11
    Conserved Domains (5) summary
    cd00063
    Location:219322
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:520796
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cd00096
    Location:47114
    Ig; Immunoglobulin domain
    pfam00041
    Location:329411
    fn3; Fibronectin type III domain
    cl11960
    Location:135216
    Ig; Immunoglobulin domain
  2. NM_001190975.1NP_001177904.1  tyrosine-protein kinase receptor UFO isoform 3 precursor

    See identical proteins and their annotated locations for NP_001177904.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons, resulting in the loss of an in-frame segment in the central coding region, compared to variant 1. The resulting protein (isoform 3) is shorter, compared to isoform 1.
    Source sequence(s)
    AC119211, AC162614
    Conserved Domains (4) summary
    cd00063
    Location:219322
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:432708
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cd00096
    Location:47114
    Ig; Immunoglobulin domain
    cl11960
    Location:135216
    Ig; Immunoglobulin domain
  3. NM_009465.4NP_033491.2  tyrosine-protein kinase receptor UFO isoform 1 precursor

    See identical proteins and their annotated locations for NP_033491.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC119211, AC162614, AK033237, BC050914
    Consensus CDS
    CCDS20996.1
    UniProtKB/Swiss-Prot
    Q00993, Q80YQ3
    Related
    ENSMUSP00000002677.5, ENSMUST00000002677.11
    Conserved Domains (5) summary
    cd00063
    Location:219322
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:529805
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cd00096
    Location:47114
    Ig; Immunoglobulin domain
    pfam00041
    Location:329411
    fn3; Fibronectin type III domain
    cl11960
    Location:135216
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    25455925..25488502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539991.5XP_006540054.1  tyrosine-protein kinase receptor UFO isoform X2

    See identical proteins and their annotated locations for XP_006540054.1

    UniProtKB/TrEMBL
    Q6PE80
    Conserved Domains (5) summary
    cd00063
    Location:219322
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:520796
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cd00096
    Location:47114
    Ig; Immunoglobulin domain
    pfam00041
    Location:329411
    fn3; Fibronectin type III domain
    cl11960
    Location:135216
    Ig; Immunoglobulin domain
  2. XM_006539989.5XP_006540052.1  tyrosine-protein kinase receptor UFO isoform X1

    See identical proteins and their annotated locations for XP_006540052.1

    UniProtKB/Swiss-Prot
    Q00993, Q80YQ3
    Conserved Domains (5) summary
    cd00063
    Location:219322
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:529805
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cd00096
    Location:47114
    Ig; Immunoglobulin domain
    pfam00041
    Location:329411
    fn3; Fibronectin type III domain
    cl11960
    Location:135216
    Ig; Immunoglobulin domain
  3. XM_006539992.3XP_006540055.1  tyrosine-protein kinase receptor UFO isoform X3

    See identical proteins and their annotated locations for XP_006540055.1

    Conserved Domains (4) summary
    cd00063
    Location:219322
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:432708
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cd00096
    Location:47114
    Ig; Immunoglobulin domain
    cl11960
    Location:135216
    Ig; Immunoglobulin domain
  4. XM_006539993.4XP_006540056.1  tyrosine-protein kinase receptor UFO isoform X4

    Conserved Domains (4) summary
    cd00063
    Location:219322
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:423699
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cd00096
    Location:47114
    Ig; Immunoglobulin domain
    cl11960
    Location:135216
    Ig; Immunoglobulin domain
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