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Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 [ Mus musculus (house mouse) ]

Gene ID: 26432, updated on 12-May-2024

Summary

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Official Symbol
Plod2provided by MGI
Official Full Name
procollagen lysine, 2-oxoglutarate 5-dioxygenase 2provided by MGI
Primary source
MGI:MGI:1347007
See related
Ensembl:ENSMUSG00000032374 AllianceGenome:MGI:1347007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LH2; Plod-2; D530025C14Rik
Summary
Predicted to enable procollagen-lysine 5-dioxygenase activity. Predicted to be involved in hydroxylysine biosynthetic process and peptidyl-lysine hydroxylation. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; cardiovascular system; sensory organ; and skeleton. Orthologous to human PLOD2 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 27.1), adrenal adult (RPKM 20.7) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 E3.3; 9 48.4 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (92421828..92490481)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (92539636..92608428)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene phospholipid scramblase 4 Neighboring gene STARR-seq mESC enhancer starr_24899 Neighboring gene RIKEN cDNA B430319G15 gene Neighboring gene predicted gene, 25417 Neighboring gene STARR-seq mESC enhancer starr_24900 Neighboring gene STARR-seq mESC enhancer starr_24901 Neighboring gene predicted gene 2495 Neighboring gene STARR-seq mESC enhancer starr_24902 Neighboring gene predicted gene 29396

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lysyl hydroxylase 2 deficiency promotes filopodia formation and fibroblast migration. Nozaki R, et al. Biochem Biophys Res Commun, 2022 Jan 8. PMID 34875533, Free PMC Article
  2. Osteoarthritis-related fibrosis is associated with both elevated pyridinoline cross-link formation and lysyl hydroxylase 2b expression. Remst DF, et al. Osteoarthritis Cartilage, 2013 Jan. PMID 23069856
  3. Overexpression of lysyl hydroxylase-2b leads to defective collagen fibrillogenesis and matrix mineralization. Pornprasertsuk S, et al. J Bone Miner Res, 2005 Jan. PMID 15619673
  4. Lysyl hydroxylase-2b directs collagen cross-linking pathways in MC3T3-E1 cells. Pornprasertsuk S, et al. J Bone Miner Res, 2004 Aug. PMID 15231023
  5. Decrease of lysyl hydroxylase 2 activity causes abnormal collagen molecular phenotypes, defective mineralization and compromised mechanical properties of bone. Saito T, et al. Bone, 2022 Jan. PMID 34718219

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The HIF-1alpha/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair.
    Title: The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair.
  2. PLOD2, a key factor for MRL MSC metabolism and chondroprotective properties.
    Title: PLOD2, a key factor for MRL MSC metabolism and chondroprotective properties.
  3. Lysyl hydroxylase 2 deficiency promotes filopodia formation and fibroblast migration.
    Title: Lysyl hydroxylase 2 deficiency promotes filopodia formation and fibroblast migration.
  4. Homozygous lysyl hydroxylase 2 knockout (LH2(-/-)) embryos failed to develop normally and died at early embryonic stage E10.5 with abnormal common ventricle in a heart, i.e., an insufficient wall, a thin ventricular wall, and loosely packed cells.
    Title: Deficiency of lysyl hydroxylase 2 in mice causes systemic endoplasmic reticulum stress leading to early embryonic lethality.
  5. Data suggest a pro-metastatic GATA3 Transcription Factor (GATA3)- lysyl hydroxylases (LHs) axis for lung cancer, supporting the notion that targeting LHs may be useful for treating lung cancer.
    Title: Lysyl hydroxylases are transcription targets for GATA3 driving lung cancer cell metastasis.
  6. FKBP65 regulates LH2-mediated collagen cross-linking.
    Title: FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch.
  7. The finding that LH2 modifies collagen in the extracellular space challenges the current view that LH2 functions solely on the endoplasmic reticulum and could also have important implications for cancer biology.
    Title: Lysyl Hydroxylase 2 Is Secreted by Tumor Cells and Can Modify Collagen in the Extracellular Space.
  8. Authors propose that lysyl hydroxylase 2, and the subsequent increase in pyridinoline cross-links, is responsible for the persistent fibrosis in experimental osteoarthritis.
    Title: Osteoarthritis-related fibrosis is associated with both elevated pyridinoline cross-link formation and lysyl hydroxylase 2b expression.
  9. TIA1 and TIAL1 regulate the alternate splicing of lysyl hydroxylase 2
    Title: TIA nuclear proteins regulate the alternate splicing of lysyl hydroxylase 2.
  10. LH2b catalyzes post-translational modification of collagen in collagen matrix formation and mineralization in bone.
    Title: Overexpression of lysyl hydroxylase-2b leads to defective collagen fibrillogenesis and matrix mineralization.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables procollagen-lysine 5-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables procollagen-lysine 5-dioxygenase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in hydroxylysine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-lysine hydroxylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-lysine hydroxylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Names
lysyl hydroxylase 2
NP_001136388.1
NP_036091.2
XP_030100253.1
XP_036010914.1
XP_036010915.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142916.1 → NP_001136388.1  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as LH2b).
    Source sequence(s)
    AC165156, AF080572, AK033363, AV488215, BB644981, CF615856
    Consensus CDS
    CCDS52887.1
    UniProtKB/TrEMBL
    E9Q718, Q3U055
    Related
    ENSMUSP00000125373.2, ENSMUST00000160359.2
    Conserved Domains (1) summary
    smart00702
    Location:593 → 756
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

  2. NM_011961.3 → NP_036091.2  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_036091.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal in-frame coding exon compared to transcript variant 1, resulting in a shorter isoform (2, also known as LH2a) missing a 21 aa protein segment compared to isoform 1.
    Source sequence(s)
    AC165156, AF080572, AV488215, BB644981, CF615856
    Consensus CDS
    CCDS23408.1
    UniProtKB/Swiss-Prot
    E9QM54, Q8VDT4, Q9R0B9
    UniProtKB/TrEMBL
    Q3U055
    Related
    ENSMUSP00000068611.8, ENSMUST00000070522.14
    Conserved Domains (2) summary
    smart00702
    Location:572 → 735
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    COG0463
    Location:347 → 572
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    92421828..92490481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155022.1 → XP_036010915.1  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform X2

    Conserved Domains (1) summary
    smart00702
    Location:220 → 383
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

  2. XM_030244393.2 → XP_030100253.1  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform X2

    Conserved Domains (1) summary
    smart00702
    Location:220 → 383
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

  3. XM_036155021.1 → XP_036010914.1  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0B9.2 GenPept UniProtKB/Swiss-Prot:Q9R0B9

Gene LinkOut

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