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OR10J1 olfactory receptor family 10 subfamily J member 1 [ Homo sapiens (human) ]

Gene ID: 26476, updated on 11-Apr-2024

Summary

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Official Symbol
OR10J1provided by HGNC
Official Full Name
olfactory receptor family 10 subfamily J member 1provided by HGNC
Primary source
HGNC:HGNC:8175
See related
Ensembl:ENSG00000196184 AllianceGenome:HGNC:8175
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HGMP07J; HSHGMP07J
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 1.9) See more
Orthologs
all
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Genomic context

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See OR10J1 in Genome Data Viewer
Location:
1q23.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (159397465..159440967)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (158534496..158578008)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159367255..159410757)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904433 Neighboring gene olfactory receptor family 10 subfamily J member 7 pseudogene Neighboring gene olfactory receptor family 10 subfamily J member 8 pseudogene Neighboring gene olfactory receptor family 10 subfamily J member 9 pseudogene Neighboring gene Sharpr-MPRA regulatory region 7346 Neighboring gene olfactory receptor family 10 subfamily J member 4 (gene/pseudogene) Neighboring gene long intergenic non-protein coding RNA 2819 Neighboring gene olfactory receptor family 10 subfamily J member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Chemerin, a novel adipokine in the regulation of angiogenesis. Bozaoglu K, et al. J Clin Endocrinol Metab, 2010 May. PMID 20237162, Free PMC Article
  2. Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. Reiner AP, et al. Am J Hum Genet, 2012 Sep 7. PMID 22939635, Free PMC Article
  3. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. Yang Q, et al. BMC Med Genet, 2007 Sep 19. PMID 17903294, Free PMC Article
  4. Genome-wide association with select biomarker traits in the Framingham Heart Study. Benjamin EJ, et al. BMC Med Genet, 2007 Sep 19. PMID 17903293, Free PMC Article
  5. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. Parmentier M, et al. Nature, 1992 Jan 30. PMID 1370859

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Chemerin, a novel adipokine in the regulation of angiogenesis.
EBI GWAS Catalog
Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study.
EBI GWAS Catalog
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
EBI GWAS Catalog
Genome-wide association with select biomarker traits in the Framingham Heart Study.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC138495, MGC138497

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables odorant binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of chemical stimulus TAS
Traceable Author Statement
more info
 PubMed 
involved_in single fertilization TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
olfactory receptor 10J1
Names
olfactory receptor OR1-26
olfactory receptor-like protein HGMP07J

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363557.2 → NP_001350486.1  olfactory receptor 10J1

    Status: VALIDATED

    Source sequence(s)
    AL513323, AL663023
    Consensus CDS
    CCDS86023.1
    UniProtKB/Swiss-Prot
    P30954, Q2M1M8, Q5VSV1, Q6IET5, Q96R56
    UniProtKB/TrEMBL
    A0A126GWQ9
    Conserved Domains (1) summary
    cd15225
    Location:25 → 300
    7tmA_OR10A-like; olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001363558.2 → NP_001350487.1  olfactory receptor 10J1

    Status: VALIDATED

    Source sequence(s)
    AL513323, AL663023
    Consensus CDS
    CCDS86023.1
    UniProtKB/Swiss-Prot
    P30954, Q2M1M8, Q5VSV1, Q6IET5, Q96R56
    UniProtKB/TrEMBL
    A0A126GWQ9
    Conserved Domains (1) summary
    cd15225
    Location:25 → 300
    7tmA_OR10A-like; olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_012351.3 → NP_036483.3  olfactory receptor 10J1

    Status: VALIDATED

    Source sequence(s)
    AL663023, BC069150
    Consensus CDS
    CCDS86023.1
    UniProtKB/Swiss-Prot
    P30954, Q2M1M8, Q5VSV1, Q6IET5, Q96R56
    UniProtKB/TrEMBL
    A0A126GWQ9
    Related
    ENSP00000399078.4, ENST00000423932.6
    Conserved Domains (1) summary
    cd15225
    Location:25 → 300
    7tmA_OR10A-like; olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    159397465..159440967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417793.1 → XP_047273749.1  olfactory receptor 10J1 isoform X1

    UniProtKB/TrEMBL
    A0A126GWQ9
    Related
    ENSP00000493228.1, ENST00000642080.1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791759.1 Reference GRCh38.p14 PATCHES

    Range
    149291..192794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332857.1 → XP_054188832.1  olfactory receptor 10J1 isoform X1

    UniProtKB/TrEMBL
    A0A126GWQ9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    158534496..158578008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335967.1 → XP_054191942.1  olfactory receptor 10J1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30954.2 GenPept UniProtKB/Swiss-Prot:P30954

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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