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PF3D7_0709700 prodrug activation and resistance esterase [ Plasmodium falciparum 3D7 ]

Gene ID: 2655076, updated on 10-Sep-2023

Summary

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Gene symbol
PF3D7_0709700
Gene description
prodrug activation and resistance esterase
Locus tag
PF3D7_0709700
Gene type
protein coding
RNA name
prodrug activation and resistance esterase
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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Location:
chromosome: 7
Exon count:
1
Sequence:
Chromosome: 7; NC_004328.3 (435089..436195, complement)

Chromosome 7 - NC_004328.3Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene ribonucleases P/MRP protein subunit POP1, putative Neighboring gene conserved protein, unknown function Neighboring gene conserved protein, unknown function

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004328.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Esterase mutation is a mechanism of resistance to antimalarial compounds. Istvan ES, et al. Nat Commun, 2017 Jan 20. PMID 28106035, Free PMC Article
  2. Functional annotation of serine hydrolases in the asexual erythrocytic stage of Plasmodium falciparum. Elahi R, et al. Sci Rep, 2019 Nov 26. PMID 31772212, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables acylglycerol lipase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity, acting on ester bonds IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within monoacylglycerol catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
prodrug activation and resistance esterase
XP_001349011.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004328.3 Reference assembly

    Range
    435089..436195 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001348975.1 → XP_001349011.1  prodrug activation and resistance esterase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001349011.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A024VA98, A0A024VSQ8, A0A024WAH0, A0A024WU99, A0A0L1I7H9, A0A0L7LZD7, Q8IBZ2, W4IK95, W7JRP3, W7K969
    Conserved Domains (1) summary
    cl21494
    Location:30 → 357
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein
Heading Accession and Version

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