parp-1 Poly [ADP-ribose] polymerase;Poly [ADP-ribose] polymerase 1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: parp-1
Gene description: Poly [ADP-ribose] polymerase;Poly [ADP-ribose] polymerase 1
Primary source: WormBase:WBGene00004049
Locus tag: CELE_Y71F9AL.18
See related: AllianceGenome:WB:WBGene00004049
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables NAD+ ADP-ribosyltransferase activity. Involved in determination of adult lifespan and protein poly-ADP-ribosylation. Predicted to be located in nucleus. Predicted to be active in nucleolus. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including arthritis; asthma; bacterial meningitis; neurodegenerative disease (multiple); and stomach carcinoma. Orthologous to human PARP1 (poly(ADP-ribose) polymerase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: I

Exon count:: 10

Sequence:: Chromosome: I; NC_003279.8 (2907730..2924713, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of PME-1 decreases embryonic survival rate of irradiated worms.
Title: Ionizing radiations in Caenorhabditis elegans induce poly(ADP-ribosyl)ation, a conserved DNA-damage response essential for survival.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y71F9A_270.a (e-PCR)
- UniSTS:323264

Y71F9A_270.b (e-PCR)
- UniSTS:323265

Y71F9A_281.a (e-PCR)
- UniSTS:323266

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NAD+ ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ ADP-ribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD+ ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+ ADP-ribosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables NAD+-protein ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein poly-ADP-ribosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein poly-ADP-ribosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein poly-ADP-ribosylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Poly [ADP-ribose] polymerase;Poly [ADP-ribose] polymerase 1

NP_001300471.1

Confirmed by transcript evidence

NP_001300472.1

Confirmed by transcript evidence

NP_001300473.1

Confirmed by transcript evidence

NP_491072.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

2907730..2924713 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058671.11 → NP_491072.1 Poly [ADP-ribose] polymerase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491072.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8MZU4, Q9N4H4

Conserved Domains (6) summary

cd08001
Location:465 → 570

WGR_PARP1_like; WGR domain of poly(ADP-ribose) polymerase 1 and similar proteins

PLN03123
Location:5 → 943

PLN03123; poly [ADP-ribose] polymerase; Provisional

cd01437
Location:586 → 938

parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

pfam00645
Location:13 → 90

zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region

pfam08063
Location:314 → 368

PADR1; PADR1 (NUC008) domain

cl02166
Location:236 → 272

RRS1; Ribosome biogenesis regulatory protein (RRS1)
NM_001313544.3 → NP_001300473.1 Poly [ADP-ribose] polymerase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ARD5

Conserved Domains (2) summary

cd01437
Location:3 → 341

parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

pfam00644
Location:129 → 341

PARP; Poly(ADP-ribose) polymerase catalytic domain
NM_001313543.3 → NP_001300472.1 Poly [ADP-ribose] polymerase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AWQ2

Conserved Domains (2) summary

cd01437
Location:1 → 250

parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

pfam00644
Location:38 → 250

PARP; Poly(ADP-ribose) polymerase catalytic domain
NM_001313542.3 → NP_001300471.1 Poly [ADP-ribose] polymerase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AUD3

Conserved Domains (1) summary

cl00283
Location:11 → 81

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...