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GPR162 G protein-coupled receptor 162 [ Homo sapiens (human) ]

Gene ID: 27239, updated on 5-Mar-2024

Summary

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Official Symbol
GPR162provided by HGNC
Official Full Name
G protein-coupled receptor 162provided by HGNC
Primary source
HGNC:HGNC:16693
See related
Ensembl:ENSG00000250510 AllianceGenome:HGNC:16693
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A-2; GRCA
Summary
This gene was identified upon genomic analysis of a gene-dense region at human chromosome 12p13. It appears to be mainly expressed in the brain; however, its function is not known. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 25.8), lung (RPKM 3.5) and 6 other tissues See more
Orthologs
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Genomic context

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See GPR162 in Genome Data Viewer
Location:
12p13.31
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (6821821..6827421)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (6831114..6836714)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6930987..6936586)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 380, pseudogene Neighboring gene Sharpr-MPRA regulatory region 1171 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:6898178-6898735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5883 Neighboring gene CD4 molecule Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6928026-6928526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6928527-6929027 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6929998-6930970 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6936229-6936797 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:6937955-6938455 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6938503-6939038 Neighboring gene prolyl 3-hydroxylase 3 Neighboring gene G protein subunit beta 3 Neighboring gene cell division cycle associated 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. mRNA GPR162 changes are associated with decreased food intake in rat, and its human genetic variants with impairments in glucose homeostasis in two Swedish cohorts. Caruso V, et al. Gene, 2016 May 1. PMID 26827797
  2. Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. Gloriam DE, et al. Biochim Biophys Acta, 2005 Apr 15. PMID 15777626
  3. A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13. Ansari-Lari MA, et al. Genome Res, 1996 Apr. PMID 8723724
  4. Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. Ansari-Lari MA, et al. Genome Res, 1997 Mar. PMID 9074930
  5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. Hosgood HD 3rd, et al. Occup Environ Med, 2009 Dec. PMID 19773279, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show certain SNPs variants in GPR162 gene associated with impairments in glucose homeostasis in obese patients.
    Title: mRNA GPR162 changes are associated with decreased food intake in rat, and its human genetic variants with impairments in glucose homeostasis in two Swedish cohorts.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: P3H3

Homology

Clone Names

  • FLJ78837

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 162
Names
gene rich cluster, A
gene-rich cluster gene A protein
NP_055264.1
NP_062832.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014449.2 → NP_055264.1  probable G-protein coupled receptor 162 isoform 1

    See identical proteins and their annotated locations for NP_055264.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A-1) differs in the 5' UTR and the 5' coding region, compared to variant A-2. The resulting isoform (1) contains a distinct N-terminus, compared to isoform 2.
    Source sequence(s)
    U47924, U47925
    Consensus CDS
    CCDS44819.1
    UniProtKB/TrEMBL
    Q96I00
    Related
    ENSP00000399670.2, ENST00000428545.6
    Conserved Domains (2) summary
    cd14964
    Location:19 → 44
    7tm_GPCRs; TM helix 7 [structural motif]
    cl28897
    Location:6 → 51
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. NM_019858.2 → NP_062832.1  probable G-protein coupled receptor 162 isoform 2

    See identical proteins and their annotated locations for NP_062832.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A-2) represents the longer transcript, and encodes the longer isoform (2).
    Source sequence(s)
    U47924, U47928
    Consensus CDS
    CCDS8563.1
    UniProtKB/Swiss-Prot
    Q16538, Q16664, Q59EH5, Q66K56
    UniProtKB/TrEMBL
    A0A0I9QPQ8
    Related
    ENSP00000311528.3, ENST00000311268.8
    Conserved Domains (1) summary
    pfam00001
    Location:34 → 207
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    6821821..6827421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    6831114..6836714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16538.1 GenPept UniProtKB/Swiss-Prot:Q16538

Gene LinkOut

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