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Abcc5 ATP-binding cassette, sub-family C member 5 [ Mus musculus (house mouse) ]

Gene ID: 27416, updated on 11-Apr-2024

Summary

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Official Symbol
Abcc5provided by MGI
Official Full Name
ATP-binding cassette, sub-family C member 5provided by MGI
Primary source
MGI:MGI:1351644
See related
Ensembl:ENSMUSG00000022822 AllianceGenome:MGI:1351644
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mrp5; Abcc5a; Abcc5b; 2900011L11Rik
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that the human protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in CNS E18 (RPKM 26.0), CNS E14 (RPKM 23.9) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 A3; 16 12.41 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (20150053..20245178, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20331303..20426428, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene presenilin associated, rhomboid-like Neighboring gene cytochrome P450, family 2, subfamily ab, polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_40320 Neighboring gene STARR-seq mESC enhancer starr_40322 Neighboring gene STARR-seq mESC enhancer starr_40323 Neighboring gene predicted gene, 41432 Neighboring gene STARR-seq mESC enhancer starr_40326 Neighboring gene STARR-seq mESC enhancer starr_40327 Neighboring gene STARR-seq mESC enhancer starr_40328 Neighboring gene eukaryotic translation initiation factor 2B, subunit 5 epsilon

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1. Cyranka M, et al. Obesity (Silver Spring), 2019 Aug. PMID 31338999, Free PMC Article
  2. Sepsis affects cardiac expression of multidrug resistance protein 5 (MRP5, ABCC5), an ABC-type CGMP export pump. Meissner K, et al. Shock, 2007 Nov. PMID 17589384
  3. Inhibition of hyaluronan export from human fibroblasts by inhibitors of multidrug resistance transporters. Prehm P, et al. Biochem Pharmacol, 2004 Oct 1. PMID 15345330
  4. An exercise-inducible metabolite that suppresses feeding and obesity. Li VL, et al. Nature, 2022 Jun. PMID 35705806, Free PMC Article
  5. MRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function. Chambers IG, et al. Proc Natl Acad Sci U S A, 2022 Feb 8. PMID 35121660, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function.
    Title: MRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function.
  2. ABCC5 is a general glutamate conjugate and analog transporter that affects the disposition of endogenous metabolites, toxins, and drugs.
    Title: ATP-binding Cassette Subfamily C Member 5 (ABCC5) Functions as an Efflux Transporter of Glutamate Conjugates and Analogs.
  3. Deficiency of MKP5 resulted in increased inflammatory activation in macrophages. These findings thus demonstrate that MKP5 critically controls inflammation in white adipose tissue and the development of metabolic disorders
    Title: Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5.
  4. Reduced cGMP export as a consequence of decreased MRP5 expression can attenuate heart failure in sepsis.
    Title: Sepsis affects cardiac expression of multidrug resistance protein 5 (MRP5, ABCC5), an ABC-type CGMP export pump.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC116567

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ABC-type transporter activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables ABC-type xenobiotic transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbohydrate derivative transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables carbohydrate derivative transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables efflux transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables glutathione transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables heme transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables macromolecule transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables macromolecule transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables purine nucleotide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables xenobiotic transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cAMP transport ISO
Inferred from Sequence Orthology
more info
  
involved_in cGMP transport ISO
Inferred from Sequence Orthology
more info
  
involved_in export across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in folate transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in glutathione transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in heme transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in hyaluronan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hyaluronan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in purine nucleotide transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xenobiotic transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP-binding cassette sub-family C member 5
Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5a
ATP-binding cassette, sub-family C (CFTR/MRP), member 5b
MOAT-C
SMRP
multi-specific organic anion transporter C
multidrug resistance-associated protein 5
NP_038818.2
NP_789809.1
XP_006522271.1
XP_006522272.1
XP_006522275.1
XP_006522276.1
XP_006522277.1
XP_006522278.1
XP_017172518.1
XP_030105004.1
XP_030105005.1
XP_030105006.1
XP_030105007.1
XP_030105008.1
XP_036015866.1
XP_036015868.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013790.2 → NP_038818.2  ATP-binding cassette sub-family C member 5 isoform 1

    See identical proteins and their annotated locations for NP_038818.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BB603250, BC090629
    Consensus CDS
    CCDS28045.1
    UniProtKB/Swiss-Prot
    O88284, Q5CZY2, Q9R1X5
    Related
    ENSMUSP00000078158.7, ENSMUST00000079158.13
    Conserved Domains (1) summary
    PLN03130
    Location:100 → 1424
    PLN03130; ABC transporter C family member; Provisional

  2. NM_176839.1 → NP_789809.1  ATP-binding cassette sub-family C member 5 isoform 2

    See identical proteins and their annotated locations for NP_789809.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exons but has two alternate 3' exons, as compared to variant 1. The encoded isoform (2) is much shorter and has a distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    BB603250, BC061132
    Consensus CDS
    CCDS28046.1
    UniProtKB/TrEMBL
    Q6P8Q2, Q8CFP9
    Related
    ENSMUSP00000093913.5, ENSMUST00000096199.5
    Conserved Domains (1) summary
    PLN03232
    Location:100 → 156
    PLN03232; ABC transporter C family member; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    20150053..20245178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522209.5 → XP_006522272.1  ATP-binding cassette sub-family C member 5 isoform X2

    Conserved Domains (1) summary
    PLN03130
    Location:59 → 1383
    PLN03130; ABC transporter C family member; Provisional

  2. XM_030249146.2 → XP_030105006.1  ATP-binding cassette sub-family C member 5 isoform X3

    Conserved Domains (1) summary
    PLN03130
    Location:45 → 1168
    PLN03130; ABC transporter C family member; Provisional

  3. XM_030249145.2 → XP_030105005.1  ATP-binding cassette sub-family C member 5 isoform X3

    Conserved Domains (1) summary
    PLN03130
    Location:45 → 1168
    PLN03130; ABC transporter C family member; Provisional

  4. XM_036159973.1 → XP_036015866.1  ATP-binding cassette sub-family C member 5 isoform X3

    Conserved Domains (1) summary
    PLN03130
    Location:45 → 1168
    PLN03130; ABC transporter C family member; Provisional

  5. XM_017317029.3 → XP_017172518.1  ATP-binding cassette sub-family C member 5 isoform X4

    Conserved Domains (1) summary
    PLN03130
    Location:103 → 952
    PLN03130; ABC transporter C family member; Provisional

  6. XM_006522213.5 → XP_006522276.1  ATP-binding cassette sub-family C member 5 isoform X4

    See identical proteins and their annotated locations for XP_006522276.1

    Conserved Domains (1) summary
    PLN03130
    Location:103 → 952
    PLN03130; ABC transporter C family member; Provisional

  7. XM_006522212.5 → XP_006522275.1  ATP-binding cassette sub-family C member 5 isoform X4

    See identical proteins and their annotated locations for XP_006522275.1

    Conserved Domains (1) summary
    PLN03130
    Location:103 → 952
    PLN03130; ABC transporter C family member; Provisional

  8. XM_006522208.4 → XP_006522271.1  ATP-binding cassette sub-family C member 5 isoform X1

    See identical proteins and their annotated locations for XP_006522271.1

    UniProtKB/Swiss-Prot
    O88284, Q5CZY2, Q9R1X5
    Conserved Domains (1) summary
    PLN03130
    Location:100 → 1424
    PLN03130; ABC transporter C family member; Provisional

  9. XM_030249144.2 → XP_030105004.1  ATP-binding cassette sub-family C member 5 isoform X2

    Conserved Domains (1) summary
    PLN03130
    Location:59 → 1383
    PLN03130; ABC transporter C family member; Provisional

  10. XM_006522215.2 → XP_006522278.1  ATP-binding cassette sub-family C member 5 isoform X5

    See identical proteins and their annotated locations for XP_006522278.1

    UniProtKB/TrEMBL
    Q6P8Q2, Q8CFP9
    Conserved Domains (1) summary
    PLN03232
    Location:100 → 156
    PLN03232; ABC transporter C family member; Provisional

  11. XM_006522214.2 → XP_006522277.1  ATP-binding cassette sub-family C member 5 isoform X5

    See identical proteins and their annotated locations for XP_006522277.1

    UniProtKB/TrEMBL
    Q6P8Q2, Q8CFP9
    Conserved Domains (1) summary
    PLN03232
    Location:100 → 156
    PLN03232; ABC transporter C family member; Provisional

  12. XM_036159975.1 → XP_036015868.1  ATP-binding cassette sub-family C member 5 isoform X5

    UniProtKB/TrEMBL
    Q6P8Q2, Q8CFP9
    Conserved Domains (1) summary
    PLN03232
    Location:100 → 156
    PLN03232; ABC transporter C family member; Provisional

  13. XM_030249148.2 → XP_030105008.1  ATP-binding cassette sub-family C member 5 isoform X5

    UniProtKB/TrEMBL
    Q6P8Q2, Q8CFP9
    Conserved Domains (1) summary
    PLN03232
    Location:100 → 156
    PLN03232; ABC transporter C family member; Provisional

  14. XM_030249147.2 → XP_030105007.1  ATP-binding cassette sub-family C member 5 isoform X5

    UniProtKB/TrEMBL
    Q6P8Q2, Q8CFP9
    Conserved Domains (1) summary
    PLN03232
    Location:100 → 156
    PLN03232; ABC transporter C family member; Provisional

RNA

  1. XR_384569.1 RNA Sequence

  2. XR_384568.1 RNA Sequence

  3. XR_001781835.3 RNA Sequence

  4. XR_001781832.3 RNA Sequence

  5. XR_001781834.3 RNA Sequence

  6. XR_001781836.3 RNA Sequence

  7. XR_001781833.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R1X5.2 GenPept UniProtKB/Swiss-Prot:Q9R1X5

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