FSHB follicle stimulating hormone subunit beta [Bos taurus (cattle)] - Gene

Summary

Gene symbol: FSHB
Gene description: follicle stimulating hormone subunit beta
See related: BGD:BT16769; Ensembl:ENSBTAG00000010889
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: FSH
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Genomic context

Location:: chromosome: 15

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	15	NC_037342.1 (60976952..60980910)

Chromosome 15 - NC_037342.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study describes generation and characterization of a new Fshb-iCre deleter strain using 4.7 kb of ovine Fshb promoter sequences driving iCre expression exclusively in the gonadotrope lineage with mice developing normally, and fertile.
Title: Fshb-iCre mice are efficient and specific Cre deleters for the gonadotrope lineage.
the novel cis-regulatory element generated by the c.-1539_-1538delGGinsTTAACT mutations might play an important role in repressing FSHB transcription, possibly leading to reduced fertility
Title: Naturally occurring genetic mutations in the 5'-upstream regulatory region of bovine FSHB generate a novel cis-regulatory element that affects its expression.
The effect of a single nucleotide polymorphism of the follicle stimulating hormone beta chain on bull fertility and semen quality is reported.
Title: Effects of novel single nucleotide polymorphisms of the FSH beta-subunit gene on semen quality and fertility in bulls.
The shift in FSH isoforms toward a greater abundance of the less acidic isoforms appears to be a key component in determining the capability for producing a preovulatory rise in estradiol.
Title: Follicle-stimulating hormone isoforms and plasma concentrations of estradiol and inhibin A in dairy cows with ovulatory and non-ovulatory follicles during the first postpartum follicle wave.
A 200-base region in the bovine FSHbeta 3' untranslated region downregulates reporter expression at the translational level via interactions between AREs in both the 3'UTR and transfactors.
Title: The 3' untranslated region of bovine follicle-stimulating hormone beta messenger RNA downregulates reporter expression: involvement of AU-rich elements and transfactors.

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General gene information

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Markers

FSH (e-PCR)
- UniSTS:251726

CSPS101 (e-PCR), detects polymorphism
- UniSTS:250963

FSHB (e-PCR), detects polymorphism
- UniSTS:279639

FSHB (e-PCR), detects polymorphism
- UniSTS:278448

FSHB (e-PCR), detects polymorphism
- UniSTS:250855

MB022 (e-PCR), detects polymorphism
- UniSTS:250855

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: follitropin subunit beta

Names: FSH-B; FSH-beta; class 1 follicle-stimulating hormone beta polypeptide; class 2 follicle-stimulating hormone beta polypeptide; follicle stimulating hormone beta subunit; follicle stimulating hormone, beta polypeptide; follicule stimulating hormone, beta polypeptide; follitropin beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.