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CMKLR2 chemerin chemokine-like receptor 2 [ Homo sapiens (human) ]

Gene ID: 2825, updated on 11-Apr-2024

Summary

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Official Symbol
CMKLR2provided by HGNC
Official Full Name
chemerin chemokine-like receptor 2provided by HGNC
Primary source
HGNC:HGNC:4463
See related
Ensembl:ENSG00000183671 MIM:600239; AllianceGenome:HGNC:4463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR1
Summary
Enables adipokinetic hormone binding activity and adipokinetic hormone receptor activity. Predicted to be involved in glucose homeostasis and neuropeptide signaling pathway. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta (RPKM 1.8), esophagus (RPKM 1.0) and 14 other tissues See more
Orthologs
mouse all
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Genomic context

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See CMKLR2 in Genome Data Viewer
Location:
2q33.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (206175316..206217912, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (206657211..206699815, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (207040040..207082636, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 beta 2 Neighboring gene small nucleolar RNA, C/D box 51 Neighboring gene small nucleolar RNA, H/ACA box 41 Neighboring gene CMKLR2 antisense RNA Neighboring gene RN7SK pseudogene 200 Neighboring gene ATP5PO pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Chemerin causes lipid metabolic imbalance and induces passive lipid accumulation in human hepatoma cell line via the receptor GPR1. Zhu L, et al. Life Sci, 2021 Aug 1. PMID 33887347
  2. International Union of Basic and Clinical Pharmacology CIII: Chemerin Receptors CMKLR1 (Chemerin(1)) and GPR1 (Chemerin(2)) Nomenclature, Pharmacology, and Function. Kennedy AJ, et al. Pharmacol Rev, 2018 Jan. PMID 29279348, Free PMC Article
  3. The synthetic peptide derived from the NH2-terminal extracellular region of an orphan G protein-coupled receptor, GPR1, preferentially inhibits infection of X4 HIV-1. Jinno-Oue A, et al. J Biol Chem, 2005 Sep 2. PMID 15919664
  4. An orphan G protein-coupled receptor, GPR1, acts as a coreceptor to allow replication of human immunodeficiency virus types 1 and 2 in brain-derived cells. Shimizu N, et al. J Virol, 1999 Jun. PMID 10233994, Free PMC Article
  5. The Atypical Chemerin Receptor GPR1 Displays Different Modes of Interaction with β-Arrestins in Humans and Mice with Important Consequences on Subcellular Localization and Trafficking. Degroot GN, et al. Cells, 2022 Mar 18. PMID 35326488, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Atypical Chemerin Receptor GPR1 Displays Different Modes of Interaction with beta-Arrestins in Humans and Mice with Important Consequences on Subcellular Localization and Trafficking.
    Title: The Atypical Chemerin Receptor GPR1 Displays Different Modes of Interaction with β-Arrestins in Humans and Mice with Important Consequences on Subcellular Localization and Trafficking.
  2. Chemerin causes lipid metabolic imbalance and induces passive lipid accumulation in human hepatoma cell line via the receptor GPR1.
    Title: Chemerin causes lipid metabolic imbalance and induces passive lipid accumulation in human hepatoma cell line via the receptor GPR1.
  3. Chemerin Isoform-Specific Effects on Hepatocyte Migration and Immune Cell Inflammation.
    Title: Chemerin Isoform-Specific Effects on Hepatocyte Migration and Immune Cell Inflammation.
  4. GPR1 protein and gene levels were significantly decreased in gestational diabetes mellitus patient placentas.
    Title: Impact of GPR1 signaling on maternal high-fat feeding and placenta metabolism in mice.
  5. The majority of presented data report down-regulation of chemerin in cancer tissue and suggest a tumor-suppressing role of chemerin in most cancer types, being mediated by recruiting innate immune defenses and by growth-inhibitory downstream signaling by chemerin receptors CMKLR1 and GPR1. (Review)
    Title: Chemerin and Cancer.
  6. CMKLR1 and GPR1 were widely expressed in vascular smooth muscle.
    Title: Chemerin Elicits Potent Constrictor Actions via Chemokine-Like Receptor 1 (CMKLR1), not G-Protein-Coupled Receptor 1 (GPR1), in Human and Rat Vasculature.
  7. The Gene-based analyses revealed four significant associations in the WT1, ZC3H12C, DLGAP2, and GPR1 genes at p < 0.05. in this study.
    Title: Genetic variation in imprinted genes is associated with risk of late-onset Alzheimer's disease.
  8. GPR1 gene is imprinted and paternally expressed in human and mouse.
    Title: A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip.
  9. identified homologous amino acid sequences in amino-terminal regions between CCR5 and GPR1/ sequences are important for G protein-coupled receptors to make the conformation critical for the interaction with the Env protein of HIV-1.
    Title: Short communication: identification of the conformational requirement for the specificities of coreceptors for human and simian immunodeficiency viruses.
  10. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Mesangial cells, an important component of the glomerulus, are susceptible to HIV-1 strains for which the viral gp120 protein uses GPR1 as a coreceptor PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adipokinetic hormone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables adipokinetic hormone receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
chemerin-like receptor 2
Names
G protein-coupled receptor 1
chemokine-like receptor 2
probable G-protein coupled receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098199.2 → NP_001091669.1  chemerin-like receptor 2

    See identical proteins and their annotated locations for NP_001091669.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    BC067833, BX094581, BX389743, DA692381, DA988428
    Consensus CDS
    CCDS2368.1
    UniProtKB/Swiss-Prot
    A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
    Conserved Domains (1) summary
    cd15119
    Location:39 → 315
    7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001261452.2 → NP_001248381.1  chemerin-like receptor 2

    See identical proteins and their annotated locations for NP_001248381.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AK312917, BC067833, DA988428, EF577403
    Consensus CDS
    CCDS2368.1
    UniProtKB/Swiss-Prot
    A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
    Related
    ENSP00000397535.1, ENST00000437420.5
    Conserved Domains (1) summary
    cd15119
    Location:39 → 315
    7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_001261453.2 → NP_001248382.1  chemerin-like receptor 2

    See identical proteins and their annotated locations for NP_001248382.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    BC067833, DA545892, DA988428, EF577403
    Consensus CDS
    CCDS2368.1
    UniProtKB/Swiss-Prot
    A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
    Conserved Domains (1) summary
    cd15119
    Location:39 → 315
    7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. NM_001261454.1 → NP_001248383.1  chemerin-like receptor 2

    See identical proteins and their annotated locations for NP_001248383.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    BC067833, BP279126, EF577403
    Consensus CDS
    CCDS2368.1
    UniProtKB/Swiss-Prot
    A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
    Conserved Domains (1) summary
    cd15119
    Location:39 → 315
    7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors

  5. NM_001261455.1 → NP_001248384.1  chemerin-like receptor 2

    See identical proteins and their annotated locations for NP_001248384.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AK312917, BC067833, BP279126, DA733626, EF577403
    Consensus CDS
    CCDS2368.1
    UniProtKB/Swiss-Prot
    A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
    Conserved Domains (1) summary
    cd15119
    Location:39 → 315
    7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors

  6. NM_001389445.1 → NP_001376374.1  chemerin-like receptor 2

    Status: VALIDATED

    Source sequence(s)
    AC007383, AK075130
    Consensus CDS
    CCDS2368.1
    UniProtKB/Swiss-Prot
    A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
    Related
    ENSP00000483003.1, ENST00000621141.5
    Conserved Domains (1) summary
    cd15119
    Location:39 → 315
    7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors

  7. NM_005279.4 → NP_005270.2  chemerin-like receptor 2

    See identical proteins and their annotated locations for NP_005270.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and all other variants encode the same protein.
    Source sequence(s)
    BC067833, BX094581, BX389743, DA692381, DA988428
    Consensus CDS
    CCDS2368.1
    UniProtKB/Swiss-Prot
    A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
    Related
    ENSP00000384345.2, ENST00000407325.6
    Conserved Domains (1) summary
    cd15119
    Location:39 → 315
    7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    206175316..206217912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443968.1 → XP_047299924.1  chemerin-like receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_015495299.1 Reference GRCh38.p14 PATCHES

    Range
    284334..326930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331981.1 → XP_054187956.1  chemerin-like receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4

  2. XM_054331980.1 → XP_054187955.1  chemerin-like receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    206657211..206699815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341421.1 → XP_054197396.1  chemerin-like receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4

  2. XM_054341420.1 → XP_054197395.1  chemerin-like receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46091.2 GenPept UniProtKB/Swiss-Prot:P46091

Gene LinkOut

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