U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slco1a4 solute carrier organic anion transporter family, member 1a4 [ Mus musculus (house mouse) ]

Gene ID: 28250, updated on 7-May-2024

Summary

Go to the top of the page Help
Official Symbol
Slco1a4provided by MGI
Official Full Name
solute carrier organic anion transporter family, member 1a4provided by MGI
Primary source
MGI:MGI:1351896
See related
Ensembl:ENSMUSG00000030237 AllianceGenome:MGI:1351896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Oatp2; Oatp1a4; Slc21a5
Summary
Enables organic anion transmembrane transporter activity. Acts upstream of or within anion transport. Located in membrane. Is expressed in choroid invagination; choroid plexus; diencephalon roof plate; medulla oblongata part of 4th ventricle choroid plexus; and metencephalon part of 4th ventricle choroid plexus. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 9.8), cortex adult (RPKM 8.3) and 2 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
6 G2; 6 72.9 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (141751164..141802011, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (141805438..141856284, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family, member 1b2 Neighboring gene STARR-seq mESC enhancer starr_17695 Neighboring gene solute carrier organic anion transporter family, member 1a7 Neighboring gene STARR-seq mESC enhancer starr_17696 Neighboring gene STARR-seq mESC enhancer starr_17697 Neighboring gene STARR-seq mESC enhancer starr_17698 Neighboring gene predicted gene, 30784 Neighboring gene predicted gene, 30843 Neighboring gene solute carrier organic anion transporter family, member 1a1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Organic Anion Transporting Polypeptide 1a4 is Responsible for the Hepatic Uptake of Cardiac Glycosides in Mice. Takano J, et al. Drug Metab Dispos, 2018 May. PMID 29348124
  2. Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism. Zhang Y, et al. Biochem Pharmacol, 2013 Aug 1. PMID 23747753, Free PMC Article
  3. Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier. Ose A, et al. Drug Metab Dispos, 2010 Jan. PMID 19833843
  4. Genomic organization and tissue-specific expression of splice variants of mouse organic anion transporting polypeptide 2. Ogura K, et al. Biochem Biophys Res Commun, 2001 Feb 23. PMID 11181066
  5. Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice. Zhang Y, et al. PLoS One, 2012. PMID 22496825, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Oatp1a4 plays a major role in the hepatic accumulation of cardiac glycosides in mice.
    Title: Organic Anion Transporting Polypeptide 1a4 is Responsible for the Hepatic Uptake of Cardiac Glycosides in Mice.
  2. Oatp1a4 does not appear to mediate the hepatic uptake of bile acid, but plays an important male-predominant role in secondary bile acid metabolism.
    Title: Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism.
  3. Oatp1a4 is more highly expressed in females than in males. Null mice showed inhibited hepatocyte transporter functions and an altered urinary metabolome.
    Title: Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles.
  4. Results show that Oatp1a4 can mediate the brain-to-blood and blood-to-brain transport of its substrate drugs across the blood-brain barrier.
    Title: Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier.
  5. Report critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp1a4 uptake transporter in mouse liver.
    Title: Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables bile acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bile acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables organic anion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in bile acid and bile salt transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic anion transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium-independent organic anion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
solute carrier organic anion transporter family member 1A4
Names
organic anion transporting polypeptide 2
sodium-independent organic anion-transporting polypeptide 2
solute carrier family 21 (organic anion transporter), member 5
solute carrier family 21 member 5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355577.2 → NP_001342506.1  solute carrier organic anion transporter family member 1A4

    Status: VALIDATED

    Source sequence(s)
    AC156277, AC164572
    Consensus CDS
    CCDS39690.1
    UniProtKB/Swiss-Prot
    Q9EP96
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 625
    oat; sodium-independent organic anion transporter

  2. NM_001410657.1 → NP_001397586.1  solute carrier organic anion transporter family member 1A4

    Status: VALIDATED

    Source sequence(s)
    AC156277, AC164572
    UniProtKB/Swiss-Prot
    Q9EP96

  3. NM_030687.3 → NP_109612.1  solute carrier organic anion transporter family member 1A4

    See identical proteins and their annotated locations for NP_109612.1

    Status: VALIDATED

    Source sequence(s)
    AC156277, AC164572
    Consensus CDS
    CCDS39690.1
    UniProtKB/Swiss-Prot
    Q9EP96
    Related
    ENSMUSP00000130746.2, ENSMUST00000165990.8
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 625
    oat; sodium-independent organic anion transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    141751164..141802011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166207.1 → XP_036022100.1  solute carrier organic anion transporter family member 1A4 isoform X3

    Conserved Domains (1) summary
    TIGR00805
    Location:16 → 411
    oat; sodium-independent organic anion transporter

  2. XM_036166204.1 → XP_036022097.1  solute carrier organic anion transporter family member 1A4 isoform X1

    UniProtKB/Swiss-Prot
    Q9EP96
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 625
    oat; sodium-independent organic anion transporter

  3. XM_036166203.1 → XP_036022096.1  solute carrier organic anion transporter family member 1A4 isoform X1

    UniProtKB/Swiss-Prot
    Q9EP96
    Related
    ENSMUSP00000032364.8, ENSMUST00000032364.14
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 625
    oat; sodium-independent organic anion transporter

  4. XM_036166206.1 → XP_036022099.1  solute carrier organic anion transporter family member 1A4 isoform X2

    Conserved Domains (1) summary
    TIGR00805
    Location:5 → 564
    oat; sodium-independent organic anion transporter

  5. XM_011241585.3 → XP_011239887.1  solute carrier organic anion transporter family member 1A4 isoform X1

    See identical proteins and their annotated locations for XP_011239887.1

    UniProtKB/Swiss-Prot
    Q9EP96
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 625
    oat; sodium-independent organic anion transporter

  6. XM_036166205.1 → XP_036022098.1  solute carrier organic anion transporter family member 1A4 isoform X2

    Conserved Domains (1) summary
    TIGR00805
    Location:5 → 564
    oat; sodium-independent organic anion transporter

RNA

  1. XR_003956207.2 RNA Sequence

  2. XR_003956206.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EP96.1 GenPept UniProtKB/Swiss-Prot:Q9EP96

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous