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dgoA 2-dehydro-3-deoxy-6-phosphogalactonate aldolase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 2847766, updated on 6-Oct-2023

Summary

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Gene symbol
dgoA
Gene description
2-dehydro-3-deoxy-6-phosphogalactonate aldolase
Primary source
ASAP:ABE-0174107
Locus tag
b4477
See related
ECOCYC:EG20049
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
b3692; ECK3685; yidU
Summary
2-oxo-3-deoxygalactonate 6-phosphate aldolase (KDPGal aldolase) catalyzes the final reaction in the degradation of D-galactonate, an aldol cleavage resulting in GA3P and pyruvate which enter central metabolism . [More information is available at EcoCyc: EG20049].
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Genomic context

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Sequence:
NC_000913.3 (3872995..3873612, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF3748 domain-containing galacturonate catabolism protein YidR Neighboring gene colicin M resistance protein Neighboring gene D-galactonate:H(+) symporter Neighboring gene D-galactonate dehydratase Neighboring gene 2-dehydro-3-deoxygalactonokinase Neighboring gene DNA-binding transcriptional regulator DgoR Neighboring gene putative lipoprotein YidX

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Directed evolution of 2-keto-3-deoxy-6-phosphogalactonate aldolase to replace 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthase. Ran N, et al. J Am Chem Soc, 2007 May 16. PMID 17451239
  2. Creation of a shikimate pathway variant. Ran N, et al. J Am Chem Soc, 2004 Jun 9. PMID 15174841
  3. A functionally diverse enzyme superfamily that abstracts the alpha protons of carboxylic acids. Babbitt PC, et al. Science, 1995 Feb 24. PMID 7855594
  4. The utilisation of D-galactonate and D-2-oxo-3-deoxygalactonate by Escherichia coli K-12. Biochemical and genetical studies. Cooper RA. Arch Microbiol, 1978 Aug 1. PMID 211976
  5. D-Galactonate utilisation by enteric bacteria. The catabolic pathway in Escherichia coli. Deacon J, et al. FEBS Lett, 1977 May 15. PMID 324806

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in D-galactonate catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within D-galactonate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
2-dehydro-3-deoxy-6-phosphogalactonate aldolase
YP_026238.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3872995..3873612 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_026238.1 2-dehydro-3-deoxy-6-phosphogalactonate aldolase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for YP_026238.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A776LN16
    Conserved Domains (1) summary
    PRK09140
    Location:1 → 203
    PRK09140; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed
Nucleotide Protein
Heading Accession and Version

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