U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GPR34 G protein-coupled receptor 34 [ Homo sapiens (human) ]

Gene ID: 2857, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
GPR34provided by HGNC
Official Full Name
G protein-coupled receptor 34provided by HGNC
Primary source
HGNC:HGNC:4490
See related
Ensembl:ENSG00000171659 MIM:300241; AllianceGenome:HGNC:4490
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPS1; LYPSR1
Summary
G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM, Apr 2006]
Expression
Broad expression in placenta (RPKM 8.9), fat (RPKM 7.8) and 21 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
Xp11.4
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (41688973..41697275)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (41093901..41102205)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (41548226..41556528)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin dependent serine protein kinase Neighboring gene YWHAZ pseudogene 10 Neighboring gene RNA, 7SL, cytoplasmic 144, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29561 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:41570764-41571264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:41571265-41571765 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:41577964-41578464 Neighboring gene G protein-coupled receptor 82 Neighboring gene ribosomal protein S15a pseudogene 39

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. G-protein Coupled Receptor 34 Promotes Gliomagenesis by Inducing Proliferation and Malignant Phenotype via TGF-Beta/Smad Signaling Pathway. Cheng Y, et al. Technol Cancer Res Treat, 2022 Jan-Dec. PMID 35770303, Free PMC Article
  2. GPR34 activation potentially bridges lymphoepithelial lesions to genesis of salivary gland MALT lymphoma. Korona B, et al. Blood, 2022 Apr 7. PMID 34086889
  3. Membrane Phospholipid Analogues as Molecular Rulers to Probe the Position of the Hydrophobic Contact Point of Lysophospholipid Ligands on the Surface of G-Protein-Coupled Receptor during Membrane Approach. Sayama M, et al. Biochemistry, 2020 Mar 24. PMID 32124599
  4. Topogenesis and cell surface trafficking of GPR34 are facilitated by positive-inside rule that effects through a tri-basic motif in the first intracellular loop. Hasegawa H, et al. Biochim Biophys Acta, 2016 Jul. PMID 27086875
  5. G-protein coupled receptor 34 knockdown impairs the proliferation and migration of HGC-27 gastric cancer cells in vitro. Jin ZT, et al. Chin Med J (Engl), 2015 Feb 20. PMID 25673461, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural basis for lysophosphatidylserine recognition by GPR34.
    Title: Structural basis for lysophosphatidylserine recognition by GPR34.
  2. Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174.
    Title: Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174.
  3. Cryo-EM structures of human GPR34 enable the identification of selective antagonists.
    Title: Cryo-EM structures of human GPR34 enable the identification of selective antagonists.
  4. G-protein Coupled Receptor 34 Promotes Gliomagenesis by Inducing Proliferation and Malignant Phenotype via TGF-Beta/Smad Signaling Pathway.
    Title: G-protein Coupled Receptor 34 Promotes Gliomagenesis by Inducing Proliferation and Malignant Phenotype via TGF-Beta/Smad Signaling Pathway.
  5. GPR34 activation potentially bridges lymphoepithelial lesions to genesis of salivary gland MALT lymphoma.
    Title: GPR34 activation potentially bridges lymphoepithelial lesions to genesis of salivary gland MALT lymphoma.
  6. G-protein coupled receptor 34 regulates the proliferation and growth of LS174T cells through differential expression of PI3K subunits and PTEN.
    Title: G-protein coupled receptor 34 regulates the proliferation and growth of LS174T cells through differential expression of PI3K subunits and PTEN.
  7. MicroRNA-381 targets G protein-Coupled receptor 34 (GPR34) to regulate the growth, migration and invasion of human cervical cancer cells.
    Title: MicroRNA-381 targets G protein-Coupled receptor 34 (GPR34) to regulate the growth, migration and invasion of human cervical cancer cells.
  8. Membrane Phospholipid Analogues as Molecular Rulers to Probe the Position of the Hydrophobic Contact Point of Lysophospholipid Ligands on the Surface of G-Protein-Coupled Receptor during Membrane Approach.
    Title: Membrane Phospholipid Analogues as Molecular Rulers to Probe the Position of the Hydrophobic Contact Point of Lysophospholipid Ligands on the Surface of G-Protein-Coupled Receptor during Membrane Approach.
  9. By monitoring fused FLAG-tag and conformation-sensitive native epitope during expression of GPR34 mutants, a tri-basic motif in the first intracellular loop was identified as key topogenic signal that dictates the orientation of transmembrane domain-1.
    Title: Topogenesis and cell surface trafficking of GPR34 are facilitated by positive-inside rule that effects through a tri-basic motif in the first intracellular loop.
  10. GPR34 knockdown impairs the proliferation and migration of HGC-27 gastric cancer cells in vitro and provides a potential implication for therapy of gastric cancer.
    Title: G-protein coupled receptor 34 knockdown impairs the proliferation and migration of HGC-27 gastric cancer cells in vitro.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of G protein-coupled receptor 34 (GPR34) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled purinergic nucleotide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
probable G-protein coupled receptor 34
Names
lysophosphatidylserine receptor 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097579.2 → NP_001091048.1  probable G-protein coupled receptor 34

    See identical proteins and their annotated locations for NP_001091048.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longer transcript. Both variants 1 and 4 encode the same protein.
    Source sequence(s)
    AK027780, AL627402, BM798913, N40174
    Consensus CDS
    CCDS14258.1
    UniProtKB/Swiss-Prot
    O95853, Q9UPC5
    UniProtKB/TrEMBL
    B3KQM5, B3KVJ9, Q5VT14
    Related
    ENSP00000367384.4, ENST00000378142.9
    Conserved Domains (1) summary
    cd15148
    Location:55 → 338
    7tmA_GPR34-like; putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_005300.4 → NP_005291.1  probable G-protein coupled receptor 34

    See identical proteins and their annotated locations for NP_005291.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. Both variants 1 and 4 encode the same protein.
    Source sequence(s)
    AK027780, AW292321, BC020678, H03136
    Consensus CDS
    CCDS14258.1
    UniProtKB/Swiss-Prot
    O95853, Q9UPC5
    UniProtKB/TrEMBL
    B3KQM5, B3KVJ9, Q5VT14
    Related
    ENSP00000367378.5, ENST00000378138.5
    Conserved Domains (1) summary
    cd15148
    Location:55 → 338
    7tmA_GPR34-like; putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    41688973..41697275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272597.5 → XP_005272654.1  probable G-protein coupled receptor 34 isoform X1

    See identical proteins and their annotated locations for XP_005272654.1

    UniProtKB/Swiss-Prot
    O95853, Q9UPC5
    UniProtKB/TrEMBL
    B3KQM5, B3KVJ9, Q5VT14
    Conserved Domains (1) summary
    cd15148
    Location:55 → 338
    7tmA_GPR34-like; putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    41093901..41102205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326884.1 → XP_054182859.1  probable G-protein coupled receptor 34 isoform X1

    UniProtKB/Swiss-Prot
    O95853, Q9UPC5
    UniProtKB/TrEMBL
    Q5VT14

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033513.2: Suppressed sequence

    Description
    NM_001033513.2: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.

  2. NM_001033514.1: Suppressed sequence

    Description
    NM_001033514.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UPC5.2 GenPept UniProtKB/Swiss-Prot:Q9UPC5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous