GRK5 G protein-coupled receptor kinase 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GRK5provided by HGNC
Official Full Name: G protein-coupled receptor kinase 5provided by HGNC
Primary source: HGNC:HGNC:4544
See related: Ensembl:ENSG00000198873 MIM:600870; AllianceGenome:HGNC:4544
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GPRK5; FP2025
Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in lung (RPKM 30.9), spleen (RPKM 17.1) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q26.11

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (119207571..119459745)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (120102994..120355311)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (120967083..121219257)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GRK5 promoted renal fibrosis via HDAC5/Smad3 signaling pathway.
Title: GRK5 promoted renal fibrosis via HDAC5/Smad3 signaling pathway.
Genetic Arg-304-His substitution in GRK5 protects against sepsis progression by alleviating NF-kappaB-mediated inflammation.
Title: Genetic Arg-304-His substitution in GRK5 protects against sepsis progression by alleviating NF-κB-mediated inflammation.
Polymorphic Variants in the GRK5 Gene Promoter Are Associated With Diastolic Dysfunction in Coronary Artery Bypass Graft Surgery Patients.
Title: Polymorphic Variants in the GRK5 Gene Promoter Are Associated With Diastolic Dysfunction in Coronary Artery Bypass Graft Surgery Patients.
lncRNA LINC01315 promotes malignancy of triple-negative breast cancer and predicts poor outcomes by modulating microRNA-876-5p/GRK5.
Title: lncRNA LINC01315 promotes malignancy of triple-negative breast cancer and predicts poor outcomes by modulating microRNA-876-5p/GRK5.
Association between gene polymorphism of GRK5 and breast cancer risk in Chinese population.
Title: Association between gene polymorphism of GRK5 and breast cancer risk in Chinese population.
GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure.
Title: GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure.
Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting.
Title: Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting.
Characterization of a hyperphosphorylated variant of G protein-coupled receptor kinase 5 expressed in E. coli.
Title: Characterization of a hyperphosphorylated variant of G protein-coupled receptor kinase 5 expressed in E. coli.
Downregulation of GRK5 hampers the migration of breast cancer cells.
Title: Downregulation of GRK5 hampers the migration of breast cancer cells.
Our results suggest that GRK5 regulates cartilage degradation through a catabolic response mediated by NF-kappaB signaling
Title: GRK5 Inhibition Attenuates Cartilage Degradation via Decreased NF-κB Signaling.

Submit: New GeneRIF Correction See all GeneRIFs (76)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

L17705 (e-PCR)
- UniSTS:66091

SHGC-156019 (e-PCR)
- UniSTS:182317

GRK5_7795 (e-PCR)
- UniSTS:466223

RH104055 (e-PCR)
- UniSTS:98380

STS-AA011510 (e-PCR)
- UniSTS:54379

SHGC-149853 (e-PCR)
- UniSTS:177261

RH120316 (e-PCR)
- UniSTS:132212

RH78041 (e-PCR)
- UniSTS:68990

D10S1701 (e-PCR), detects polymorphism
- UniSTS:67975

L17877 (e-PCR)
- UniSTS:61334

STS-L15388 (e-PCR)
- UniSTS:51357

WI-19887 (e-PCR)
- UniSTS:32941

WI-4736 (e-PCR)
- UniSTS:11440

SHGC-105094 (e-PCR)
- UniSTS:169148

SHGC-89038 (e-PCR)
- UniSTS:104896

RH103139 (e-PCR)
- UniSTS:97473

RH69017 (e-PCR)
- UniSTS:21210

SHGC-77890 (e-PCR)
- UniSTS:101347

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor kinase activity	IEA Inferred from Electronic Annotation more info
enables beta-adrenergic receptor kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables beta-adrenergic receptor kinase activity	TAS Traceable Author Statement more info
enables phospholipid binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase C binding	TAS Traceable Author Statement more info	PubMed
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in tachykinin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info
located_in nuclear speck	IDA Inferred from Direct Assay more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: G protein-coupled receptor kinase 5

Names: g protein-coupled receptor kinase GRK5

NP_005299.1

EC 2.7.11.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005308.3 → NP_005299.1 G protein-coupled receptor kinase 5

See identical proteins and their annotated locations for NP_005299.1

Status: REVIEWED

Source sequence(s)

AL355273, AL355861, BC018116, BC064506, BQ184611, CN290123, L15388

Consensus CDS

CCDS7612.1

UniProtKB/Swiss-Prot

D3DRD0, P34947, Q5T059

UniProtKB/TrEMBL

B2R7K0

Related

ENSP00000376609.2, ENST00000392870.3

Conserved Domains (3) summary

cd08752
Location:53 → 175

RGS_GRK5; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 5 (GRK5)

smart00220
Location:186 → 448

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05632
Location:183 → 495

STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5