Itm2b integral membrane protein 2B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Itm2bprovided by RGD
Official Full Name: integral membrane protein 2Bprovided by RGD
Primary source: RGD:620727
See related: Ensembl:ENSRNOG00000016271 AllianceGenome:RGD:620727
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bri; imBRI2
Summary: Predicted to enable ATP binding activity and amyloid-beta binding activity. Predicted to be involved in negative regulation of amyloid precursor protein biosynthetic process. Predicted to act upstream of or within extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in Golgi-associated vesicle membrane and extracellular space. Predicted to be integral component of organelle membrane. Predicted to be active in Golgi apparatus and plasma membrane. Human ortholog(s) of this gene implicated in ITM2B-related cerebral amyloid angiopathy 1 and ITM2B-related cerebral amyloid angiopathy 2. Orthologous to human ITM2B (integral membrane protein 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 3695.2), Lung (RPKM 2207.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15q11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (54955549..54978455, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (48545998..48568904, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (55254703..55277713, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A familial Danish dementia rat shows impaired presynaptic and postsynaptic glutamatergic transmission.
Title: A familial Danish dementia rat shows impaired presynaptic and postsynaptic glutamatergic transmission.
the resulting BRI2 brain interactome, associates this protein with neurite outgrowth and neuronal differentiation, as well as synaptic signalling and plasticity. It follows that further studies should address BRI2 particularly given its relevance to neuropathological conditions.
Title: Identification and characterization of the BRI2 interactome in the brain.
Itm2b expression was detected strong in the rat testis, epididymis, and vas deferens from day 1 - 70. When the rats were castrated or treated with ethylene dimethane sulfonate (EDS), Itm2b expression was protected in the epididymis and vas deferens by administered testosterone.
Title: Differential expression and regulation of integral membrane protein 2b in rat male reproductive tissues.
by modulating BRI2 processing using an ADAM10 inhibitor, a dual role for BRI2 in neurite outgrowth is suggested: phosphorylated full-length BRI2 appears to be important for the formation of neuritic processes, and BRI2 NTF promotes neurite elongation.
Title: BRI2 Processing and Its Neuritogenic Role Are Modulated by Protein Phosphatase 1 Complexing.
when BRI2 is phosphorylated a significant increase in neuronal outgrowth and differentiation is evident
Title: BRI2 and BRI3 are functionally distinct phosphoproteins.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142259 (e-PCR)
- UniSTS:231506

RH129302 (e-PCR)
- UniSTS:212609

RH141160 (e-PCR)
- UniSTS:223156

RH142637 (e-PCR)
- UniSTS:231884

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	IBA Inferred from Biological aspect of Ancestor more info
enables amyloid-beta binding	IEA Inferred from Electronic Annotation more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid precursor protein biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of amyloid precursor protein biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of amyloid precursor protein biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid precursor protein biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi-associated vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi-associated vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi-associated vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in organelle membrane	ISO Inferred from Sequence Orthology more info
located_in organelle membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: integral membrane protein 2B

Names: immature BRI2; transmembrane protein BRI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006963.1 → NP_001006964.1 integral membrane protein 2B

See identical proteins and their annotated locations for NP_001006964.1

Status: PROVISIONAL

Source sequence(s)

BC083735

UniProtKB/Swiss-Prot

Q5XIE8

UniProtKB/TrEMBL

A0A8I5ZPB1, A6HTQ5

Related

ENSRNOP00000023037.3, ENSRNOT00000023037.6

Conserved Domains (1) summary

smart01039
Location:137 → 231

BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer