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Rpsa ribosomal protein SA [ Rattus norvegicus (Norway rat) ]

Gene ID: 29236, updated on 11-Apr-2024

Summary

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Official Symbol
Rpsaprovided by RGD
Official Full Name
ribosomal protein SAprovided by RGD
Primary source
RGD:71026
See related
AllianceGenome:RGD:71026
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lamr1
Summary
Predicted to enable laminin binding activity and ribosome binding activity. Predicted to be a structural constituent of ribosome. Involved in cell-cell adhesion and epithelial cell differentiation. Located in several cellular components, including basement membrane; cytosol; and neuronal cell body. Part of cytosolic small ribosomal subunit. Biomarker of irritable bowel syndrome and sciatic neuropathy. Orthologous to human RPSA (ribosomal protein SA). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 4436.8), Thymus (RPKM 3739.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q32
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (128728761..128732736)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (119851225..119855103)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (128806053..128809987)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine receptor 8 Neighboring gene solute carrier family 25, member 38 Neighboring gene small nucleolar RNA, H/ACA box 73B like 1 Neighboring gene small nucleolar RNA, H/ACA box 6 like 1 Neighboring gene uncharacterized LOC134480248 Neighboring gene small nucleolar RNA, H/ACA box 62 like 1 Neighboring gene myelin-associated oligodendrocyte basic protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Regional Specific Alterations in BBB Permeability are Relevant to the Differential Responses of 67-kDa LR Expression in Endothelial Cells and Astrocytes Following Status Epilepticus. Park H, et al. Int J Mol Sci, 2019 Nov 29. PMID 31795399, Free PMC Article
  2. Green tea catechins potentiate the neuritogenic action of brain-derived neurotrophic factor: role of 67-kDa laminin receptor and hydrogen peroxide. Gundimeda U, et al. Biochem Biophys Res Commun, 2014 Feb 28. PMID 24508265
  3. Proteomic analysis of colonic mucosa in a rat model of irritable bowel syndrome. Ding Y, et al. Proteomics, 2010 Jul. PMID 20461717
  4. Upregulation in rat spinal cord microglia of the nonintegrin laminin receptor 37 kDa-LRP following activation by a traumatic lesion or peripheral injury. Baloui H, et al. J Neurotrauma, 2009 Feb 11. PMID 19196078
  5. Cellular prion protein/laminin receptor: distribution in adult central nervous system and characterization of an isoform associated with a subtype of cortical neurons. Baloui H, et al. Eur J Neurosci, 2004 Nov. PMID 15548204

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Blockade of 67-kDa Laminin Receptor Facilitates AQP4 Down-Regulation and BBB Disruption via ERK1/2-and p38 MAPK-Mediated PI3K/AKT Activations.
    Title: Blockade of 67-kDa Laminin Receptor Facilitates AQP4 Down-Regulation and BBB Disruption via ERK1/2-and p38 MAPK-Mediated PI3K/AKT Activations.
  2. These findings suggested that 67-kDa laminin receptor expression level might be involved in Blood-Brain Barrier integrity in regional specific manners, which might affect the susceptibility to Status Epilepticus induction.
    Title: The Regional Specific Alterations in BBB Permeability are Relevant to the Differential Responses of 67-kDa LR Expression in Endothelial Cells and Astrocytes Following Status Epilepticus.
  3. Data indicate that green tea polyphenols (GTPP)-induced potentiation of brain-derived neurotrophic factor (BDNF) action required the cell-surface associated 67 kDa laminin receptor (67LR).
    Title: Green tea catechins potentiate the neuritogenic action of brain-derived neurotrophic factor: role of 67-kDa laminin receptor and hydrogen peroxide.
  4. involvement of LRP in lesion-induced activation and migration of microglia
    Title: Upregulation in rat spinal cord microglia of the nonintegrin laminin receptor 37 kDa-LRP following activation by a traumatic lesion or peripheral injury.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables laminin binding ISO
Inferred from Sequence Orthology
more info
  
enables laminin receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
enables structural molecule activity IC
Inferred by Curator
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epithelial cell differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of rough endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein uS2
Names
laminin receptor 1 (67kD, ribosomal protein SA)
laminin receptor 1 (ribosomal protein SA)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017138.2 → NP_058834.1  small ribosomal subunit protein uS2

    See identical proteins and their annotated locations for NP_058834.1

    Status: PROVISIONAL

    Source sequence(s)
    D25224
    UniProtKB/Swiss-Prot
    B6ZB78, P38983
    UniProtKB/TrEMBL
    A6I3Z4
    Conserved Domains (1) summary
    PTZ00254
    Location:1 → 250
    PTZ00254; 40S ribosomal protein SA; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    128728761..128732736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265009.1 → XP_063121079.1  small ribosomal subunit protein uS2 isoform X1

    UniProtKB/TrEMBL
    A0A8L2UK17
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38983.3 GenPept UniProtKB/Swiss-Prot:P38983

Gene LinkOut

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