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Pak3 p21 (RAC1) activated kinase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29433, updated on 13-Apr-2024

Summary

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Official Symbol
Pak3provided by RGD
Official Full Name
p21 (RAC1) activated kinase 3provided by RGD
Primary source
RGD:3251
See related
Ensembl:ENSRNOG00000004676 AllianceGenome:RGD:3251
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
beta-PAK
Summary
Enables GTPase binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of DNA biosynthetic process; positive regulation of dendritic spine morphogenesis; and positive regulation of fibroblast migration. Located in endosome. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 30. Orthologous to human PAK3 (p21 (RAC1) activated kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 136.9), Testes (RPKM 64.9) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pak3 in Genome Data Viewer
Location:
Xq33
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (111912967..112171037)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (107116308..107374342)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (114784452..115042683)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S17, pseudogene 2 Neighboring gene chordin-like 1 Neighboring gene calpain 6 Neighboring gene doublecortin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of AMPA receptor subunit GluA1 surface expression by PAK3 phosphorylation. Hussain NK, et al. Proc Natl Acad Sci U S A, 2015 Oct 27. PMID 26460013, Free PMC Article
  2. Alteration of synaptic network dynamics by the intellectual disability protein PAK3. Dubos A, et al. J Neurosci, 2012 Jan 11. PMID 22238087, Free PMC Article
  3. Distinct, but compensatory roles of PAK1 and PAK3 in spine morphogenesis. Boda B, et al. Hippocampus, 2008. PMID 18481281
  4. Light-Induced photoreceptor degeneration in the mouse involves activation of the small GTPase Rac1. Belmonte MA, et al. Invest Ophthalmol Vis Sci, 2006 Mar. PMID 16505058
  5. The p21-activated kinase 3 implicated in mental retardation regulates spine morphogenesis through a Cdc42-dependent pathway. Kreis P, et al. J Biol Chem, 2007 Jul 20. PMID 17537723

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. specific loss of PAK3 expression and pharmacological inhibition of PAK both disrupt activity-dependent phosphorylation of S863 in cortical neurons
    Title: Regulation of AMPA receptor subunit GluA1 surface expression by PAK3 phosphorylation.
  2. Results show elevated PAK3 expression at both the mRNA and protein level in cJun/AP-1-over-expressing Rat1a fibroblasts, as well as in transformed human fibroblasts.
    Title: p21-activated kinase 3 (PAK3) is an AP-1 regulated gene contributing to actin organisation and migration of transformed fibroblasts.
  3. PAK3 regulates activity-mediated rearrangement of synaptic connectivity associated with learning, suggesting that defects in spine formation and refinement during development could account for intellectual disability.
    Title: Alteration of synaptic network dynamics by the intellectual disability protein PAK3.
  4. While PAK1 and PAK3 share distinct roles in the regulation of spine morphogenesis, their activity may overlap, allowing compensation of the PAK3 deficit by PAK1.
    Title: Distinct, but compensatory roles of PAK1 and PAK3 in spine morphogenesis.
  5. the Cdc42/PAK3 is a key module in dendritic spine formation and synaptic plasticity
    Title: The p21-activated kinase 3 implicated in mental retardation regulates spine morphogenesis through a Cdc42-dependent pathway.
  6. A normal signaling pathway mediated by the interaction of amyloid precursor protein [APP], PAK3, and heterotrimeric Go protein is constitutively activated in neurons by familial Alzheimer mutations in APP causing cell cycle entry and consequent apoptosis
    Title: DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3.
  7. Antisense and small interfering RNA-mediated suppression of PAK3 in rat hippocampal organotypic slice cultures results in the formation of abnormally elongated dendritic spines and filopodia-like protrusions and a decrease in mature spine synapses.
    Title: The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables MAP kinase kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in axonogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
  
involved_in dendrite development ISO
Inferred from Sequence Orthology
more info
  
involved_in dendrite development ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within dendritic spine development ISO
Inferred from Sequence Orthology
more info
  
involved_in dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of DNA biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of fibroblast migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of postsynapse organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynapse organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase PAK 3
Names
PAK-3
p21 (CDKN1A)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
p21-activated kinase 3
p21/Cdc42/Rac1-activated kinase 3 (yeast Ste20-related)
p65-PAK
NP_062083.1
XP_006257395.1
XP_006257401.1
XP_008771626.1
XP_017457426.1
XP_017457428.1
XP_017457429.1
XP_017457431.1
XP_038955465.1
XP_063135912.1
XP_063135913.1
XP_063135914.1
XP_063135915.1
XP_063135916.1
XP_063135917.1
XP_063135918.1
XP_063135919.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019210.2 → NP_062083.1  serine/threonine-protein kinase PAK 3

    See identical proteins and their annotated locations for NP_062083.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/Swiss-Prot
    Q62829
    UniProtKB/TrEMBL
    A0A8I5ZSQ0, A6KG82
    Related
    ENSRNOP00000006459.4, ENSRNOT00000006459.6
    Conserved Domains (3) summary
    cd06656
    Location:248 → 544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    smart00220
    Location:268 → 519
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00786
    Location:69 → 124
    PBD; P21-Rho-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    111912967..112171037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279845.1 → XP_063135915.1  serine/threonine-protein kinase PAK 3 isoform X4

    UniProtKB/Swiss-Prot
    Q62829
    UniProtKB/TrEMBL
    A6KG82

  2. XM_063279849.1 → XP_063135919.1  serine/threonine-protein kinase PAK 3 isoform X4

    UniProtKB/Swiss-Prot
    Q62829
    UniProtKB/TrEMBL
    A6KG82

  3. XM_017601940.3 → XP_017457429.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZSQ0
    Conserved Domains (2) summary
    cd06656
    Location:284 → 580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  4. XM_063279842.1 → XP_063135912.1  serine/threonine-protein kinase PAK 3 isoform X2

  5. XM_039099537.2 → XP_038955465.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZSQ0
    Conserved Domains (2) summary
    cd06656
    Location:284 → 580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  6. XM_063279843.1 → XP_063135913.1  serine/threonine-protein kinase PAK 3 isoform X3

    UniProtKB/TrEMBL
    A0A8L2RA18

  7. XM_017601937.3 → XP_017457426.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZSQ0
    Conserved Domains (2) summary
    cd06656
    Location:284 → 580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  8. XM_008773404.4 → XP_008771626.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZSQ0
    Conserved Domains (2) summary
    cd06656
    Location:284 → 580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  9. XM_017601942.3 → XP_017457431.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZSQ0
    Conserved Domains (2) summary
    cd06656
    Location:284 → 580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  10. XM_006257333.5 → XP_006257395.1  serine/threonine-protein kinase PAK 3 isoform X3

    See identical proteins and their annotated locations for XP_006257395.1

    UniProtKB/TrEMBL
    A0A8I5ZSQ0, A0A8L2RA18
    Related
    ENSRNOP00000075221.2
    Conserved Domains (2) summary
    cd06656
    Location:263 → 559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 141
    PBD; P21-Rho-binding domain

  11. XM_063279848.1 → XP_063135918.1  serine/threonine-protein kinase PAK 3 isoform X4

    UniProtKB/Swiss-Prot
    Q62829
    UniProtKB/TrEMBL
    A6KG82

  12. XM_006257339.5 → XP_006257401.1  serine/threonine-protein kinase PAK 3 isoform X4

    See identical proteins and their annotated locations for XP_006257401.1

    UniProtKB/Swiss-Prot
    Q62829
    UniProtKB/TrEMBL
    A0A8I5ZSQ0, A6KG82
    Conserved Domains (3) summary
    cd06656
    Location:248 → 544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    smart00220
    Location:268 → 519
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00786
    Location:69 → 124
    PBD; P21-Rho-binding domain

  13. XM_063279846.1 → XP_063135916.1  serine/threonine-protein kinase PAK 3 isoform X4

    UniProtKB/Swiss-Prot
    Q62829
    UniProtKB/TrEMBL
    A6KG82

  14. XM_063279847.1 → XP_063135917.1  serine/threonine-protein kinase PAK 3 isoform X4

    UniProtKB/Swiss-Prot
    Q62829
    UniProtKB/TrEMBL
    A6KG82

  15. XM_063279844.1 → XP_063135914.1  serine/threonine-protein kinase PAK 3 isoform X3

    UniProtKB/TrEMBL
    A0A8L2RA18

  16. XM_017601939.3 → XP_017457428.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZSQ0
    Conserved Domains (2) summary
    cd06656
    Location:284 → 580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62829.1 GenPept UniProtKB/Swiss-Prot:Q62829

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