Pitpna phosphatidylinositol transfer protein, alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pitpnaprovided by RGD
Official Full Name: phosphatidylinositol transfer protein, alphaprovided by RGD
Primary source: RGD:61885
See related: Ensembl:ENSRNOG00000003846 AllianceGenome:RGD:61885
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pitpn
Summary: Enables several functions, including phospholipid binding activity; phospholipid transfer activity; and stearic acid binding activity. Involved in phospholipid transport. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human PITPNA (phosphatidylinositol transfer protein alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 485.3), Heart (RPKM 323.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (60929050..60969614)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (60430712..60473564)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (63731767..63772049)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that (1) interaction of Pitpna with membrane/lipid bilayer is spontaneous and mediated by four specific protein substructures; (2) ability of Pitpna to initiate closure around PC ligand is accompanied by loss of flexibility of two helix/loop regions, as well as of C-terminal helix; (3) energy barrier of PC/PI extraction from membrane is lowered by hydrogen bonding between lipid and Pitpna.
Title: Dynamics and energetics of the mammalian phosphatidylinositol transfer protein phospholipid exchange cycle.
Lower protein expression of PI-TP(alpha and beta) in aged brain and in PD.
Title: Phosphatidylinositol transfer protein expression altered by aging and Parkinson disease.
Cys-to-Ala mutations of PITP show that neither Cys95 nor Cys188 is essential for lipid transfer activity; however, chemical modification of Cys95 results in the loss of lipid transfer activity.
Title: Modifications of cysteine residues in the solution and membrane-associated conformations of phosphatidylinositol transfer protein have differential effects on lipid transfer activity.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fatty-acyl-CoA binding	IDA Inferred from Direct Assay more info	PubMed
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylcholine binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylcholine binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine transfer activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine transfer activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylcholine transfer activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylcholine transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylcholine transporter activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol transfer activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol transfer activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylinositol transfer activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol transfer activity	TAS Traceable Author Statement more info	PubMed
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables stearic acid binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in axonogenesis	IEA Inferred from Electronic Annotation more info
involved_in axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
involved_in phospholipid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid transport	IEA Inferred from Electronic Annotation more info
involved_in phospholipid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: phosphatidylinositol transfer protein alpha isoform

Names: PI-TP-alpha; ptdIns transfer protein alpha; ptdInsTP alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017231.1 → NP_058927.1 phosphatidylinositol transfer protein alpha isoform

See identical proteins and their annotated locations for NP_058927.1

Status: PROVISIONAL

Source sequence(s)

M25758

UniProtKB/Swiss-Prot

P16446

UniProtKB/TrEMBL

R9PXS4

Related

ENSRNOP00000005368.7, ENSRNOT00000005368.8

Conserved Domains (1) summary

cd08888
Location:3 → 260

SRPBCC_PITPNA-B_like; Lipid-binding SRPBCC domain of mammalian PITPNA, -B, and related proteins (Class I PITPs)