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Vav3 vav guanine nucleotide exchange factor 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295378, updated on 13-Apr-2024

Summary

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Official Symbol
Vav3provided by RGD
Official Full Name
vav guanine nucleotide exchange factor 3provided by RGD
Primary source
RGD:1565941
See related
Ensembl:ENSRNOG00000020485 AllianceGenome:RGD:1565941
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565941
Summary
Predicted to enable epidermal growth factor receptor binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including B cell receptor signaling pathway; positive regulation of B cell proliferation; and regulation of cell size. Predicted to act upstream of or within several processes, including integrin-mediated signaling pathway; neutrophil chemotaxis; and positive regulation of phosphatidylinositol 3-kinase activity. Predicted to be located in cytoplasm and immunological synapse. Orthologous to human VAV3 (vav guanine nucleotide exchange factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 137.3), Kidney (RPKM 129.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q41
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (199699861..200042344)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (197011901..197354321)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (212247061..212585818)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 25, member 54 Neighboring gene solute carrier family 25 member 24 Neighboring gene uncharacterized LOC120100608 Neighboring gene uncharacterized LOC120100920 Neighboring gene mitochondrial ribosomal protein S17, pseudogene 1 Neighboring gene uncharacterized LOC120100919 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene netrin G1 Neighboring gene uncharacterized LOC120100921

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Rho protein exchange factor Vav3 regulates vascular smooth muscle cell proliferation and migration. Toumaniantz G, et al. Cardiovasc Res, 2010 Apr 1. PMID 19969623
  2. Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76. Charvet C, et al. J Biol Chem, 2005 Apr 15. PMID 15708849
  3. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Crespo P, et al. Nature, 1997 Jan 9. PMID 8990121
  4. P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses. Lawson CD, et al. J Immunol, 2011 Feb 1. PMID 21178006
  5. ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia. Joshi AD, et al. Clin Cancer Res, 2007 Sep 15. PMID 17875758

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of Vav3 expression for inflammation and cell death during experimental myocardial infarction.
    Title: The role of Vav3 expression for inflammation and cell death during experimental myocardial infarction.
  2. The Rho GEF Vav3 controls vascular smooth muscle cell proliferation and migration through activation of Rac1/PAK signalling
    Title: The Rho protein exchange factor Vav3 regulates vascular smooth muscle cell proliferation and migration.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell projection assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in regulation of cell size ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell size ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within vesicle fusion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
guanine nucleotide exchange factor VAV3
Names
vav 3 guanine nucleotide exchange factor
vav 3 oncogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191714.1 → NP_001178643.1  guanine nucleotide exchange factor VAV3

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I5ZPB5, A0A8I6A8C8
    Related
    ENSRNOP00000080097.1, ENSRNOT00000098387.1
    Conserved Domains (8) summary
    cd10407
    Location:666 → 768
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:791 → 846
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:596 → 657
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00029
    Location:514 → 561
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:193 → 369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam00169
    Location:407 → 502
    PH; PH domain
    pfam11971
    Location:18 → 103
    CAMSAP_CH; CAMSAP CH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    199699861..200042344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017590775.3 → XP_017446264.1  guanine nucleotide exchange factor VAV3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A8C8
    Related
    ENSRNOP00000027813.6

  2. XM_063281659.1 → XP_063137729.1  guanine nucleotide exchange factor VAV3 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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