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Orc4 origin recognition complex, subunit 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295596, updated on 11-Apr-2024

Summary

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Official Symbol
Orc4provided by RGD
Official Full Name
origin recognition complex, subunit 4provided by RGD
Primary source
RGD:735212
See related
Ensembl:ENSRNOG00000005021 AllianceGenome:RGD:735212
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA replication origin binding activity and nucleotide binding activity. Predicted to be involved in DNA replication initiation. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of nuclear origin of replication recognition complex. Predicted to colocalize with chromosome, telomeric region. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 2. Orthologous to human ORC4 (origin recognition complex subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 140.3), Adrenal (RPKM 134.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q12
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (53700046..53743293, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (33290844..33334022, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (33034913..33075833, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486360 Neighboring gene uncharacterized LOC108350372 Neighboring gene uncharacterized LOC134486282 Neighboring gene activin A receptor type 2A Neighboring gene methyl-CpG binding domain protein 5 Neighboring gene uncharacterized LOC120101434 Neighboring gene enhancer of polycomb homolog 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Protein components of a rat brain synaptic junctional protein preparation. Langnaese K, et al. Brain Res Mol Brain Res, 1996 Nov. PMID 8915587
  2. Identification of HsORC4, a member of the human origin of replication recognition complex. Quintana DG, et al. J Biol Chem, 1997 Nov 7. PMID 9353276
  3. Identification and characterization of MmORC4 and MmORC5, two subunits of the mouse origin of replication recognition complex. Springer J, et al. Chromosoma, 1999 Aug. PMID 10460412
  4. ATP-dependent assembly of the human origin recognition complex. Siddiqui K, et al. J Biol Chem, 2007 Nov 2. PMID 17716973
  5. A WD-repeat protein stabilizes ORC binding to chromatin. Shen Z, et al. Mol Cell, 2010 Oct 8. PMID 20932478, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC72574

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA replication origin binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA replication origin binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA replication origin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA replication initiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in polar body extrusion after meiotic divisions IEA
Inferred from Electronic Annotation
more info
  
involved_in polar body extrusion after meiotic divisions ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polymerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear origin of replication recognition complex IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear origin of replication recognition complex ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear origin of replication recognition complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of origin recognition complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
origin recognition complex subunit 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199092.1 → NP_954523.1  origin recognition complex subunit 4

    See identical proteins and their annotated locations for NP_954523.1

    Status: PROVISIONAL

    Source sequence(s)
    BC060516
    UniProtKB/Swiss-Prot
    Q6P9Z8
    UniProtKB/TrEMBL
    A0A8L2Q2Z8, A6JEZ2
    Related
    ENSRNOP00000006937.4, ENSRNOT00000006937.6
    Conserved Domains (2) summary
    COG1474
    Location:41 → 224
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:226 → 413
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    53700046..53743293 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104470.2 → XP_038960398.1  origin recognition complex subunit 4 isoform X3

    UniProtKB/TrEMBL
    A0A8L2Q2Z8
    Conserved Domains (2) summary
    COG1474
    Location:41 → 238
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:240 → 427
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

  2. XM_063283239.1 → XP_063139309.1  origin recognition complex subunit 4 isoform X1

  3. XM_039104469.2 → XP_038960397.1  origin recognition complex subunit 4 isoform X3

    UniProtKB/TrEMBL
    A0A8L2Q2Z8
    Conserved Domains (2) summary
    COG1474
    Location:41 → 238
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:240 → 427
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

  4. XM_039104474.2 → XP_038960402.1  origin recognition complex subunit 4 isoform X6

    UniProtKB/TrEMBL
    A0A8L2Q2Z8
    Conserved Domains (2) summary
    COG1474
    Location:54 → 204
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:209 → 368
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

  5. XM_039104465.2 → XP_038960393.1  origin recognition complex subunit 4 isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q2Z8
    Conserved Domains (2) summary
    COG1474
    Location:54 → 251
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:253 → 440
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

  6. XM_039104464.2 → XP_038960392.1  origin recognition complex subunit 4 isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q2Z8
    Conserved Domains (2) summary
    COG1474
    Location:54 → 251
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:253 → 440
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

  7. XM_063283246.1 → XP_063139316.1  origin recognition complex subunit 4 isoform X5

    UniProtKB/Swiss-Prot
    Q6P9Z8
    UniProtKB/TrEMBL
    A6JEZ2

  8. XM_039104471.2 → XP_038960399.1  origin recognition complex subunit 4 isoform X3

    UniProtKB/TrEMBL
    A0A8L2Q2Z8
    Conserved Domains (2) summary
    COG1474
    Location:41 → 238
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:240 → 427
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

  9. XM_063283244.1 → XP_063139314.1  origin recognition complex subunit 4 isoform X4

    UniProtKB/TrEMBL
    A0A8I5Y5K9

  10. XM_063283240.1 → XP_063139310.1  origin recognition complex subunit 4 isoform X1

  11. XM_063283243.1 → XP_063139313.1  origin recognition complex subunit 4 isoform X4

    UniProtKB/TrEMBL
    A0A8I5Y5K9

  12. XM_039104463.2 → XP_038960391.1  origin recognition complex subunit 4 isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q2Z8
    Conserved Domains (2) summary
    COG1474
    Location:54 → 251
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:253 → 440
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

  13. XM_039104461.2 → XP_038960389.1  origin recognition complex subunit 4 isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q2Z8
    Conserved Domains (2) summary
    COG1474
    Location:54 → 251
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:253 → 440
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

  14. XM_008761705.4 → XP_008759927.1  origin recognition complex subunit 4 isoform X4

    See identical proteins and their annotated locations for XP_008759927.1

    UniProtKB/TrEMBL
    A0A8I5Y5K9, A0A8L2Q2Z8
    Related
    ENSRNOP00000077265.1
    Conserved Domains (3) summary
    cd00009
    Location:57 → 224
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    smart00382
    Location:72 → 228
    AAA; ATPases associated with a variety of cellular activities
    pfam14629
    Location:239 → 416
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

  15. XM_063283242.1 → XP_063139312.1  origin recognition complex subunit 4 isoform X4

    UniProtKB/TrEMBL
    A0A8I5Y5K9

  16. XM_039104460.2 → XP_038960388.1  origin recognition complex subunit 4 isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q2Z8
    Conserved Domains (2) summary
    COG1474
    Location:54 → 251
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:253 → 440
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

  17. XM_039104472.2 → XP_038960400.1  origin recognition complex subunit 4 isoform X3

    UniProtKB/TrEMBL
    A0A8L2Q2Z8
    Conserved Domains (2) summary
    COG1474
    Location:41 → 238
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:240 → 427
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

  18. XM_039104473.2 → XP_038960401.1  origin recognition complex subunit 4 isoform X6

    UniProtKB/TrEMBL
    A0A8L2Q2Z8
    Conserved Domains (2) summary
    COG1474
    Location:54 → 204
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:209 → 368
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

  19. XM_039104466.2 → XP_038960394.1  origin recognition complex subunit 4 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A4W8, A0A8L2Q2Z8
    Conserved Domains (2) summary
    COG1474
    Location:48 → 245
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:247 → 434
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P9Z8.1 GenPept UniProtKB/Swiss-Prot:Q6P9Z8

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