gsc goosecoid [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gscprovided by ZNC
Official Full Name: goosecoidprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980528-2060
See related: Ensembl:ENSDARG00000059073 AllianceGenome:ZFIN:ZDB-GENE-980528-2060
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ZGSC; zgc:101595; ik:tdsubc_2g4; xx:tdsubc_2g4; ik:tdsubc_1c10; ik:tdsubc_2h11; xx:tdsubc_1c10; xx:tdsubc_2h11
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including neuroblast delamination; otic vesicle development; and regionalization. Predicted to be active in nucleus. Is expressed in several structures, including blastodisc; germ ring; mesoderm; neural keel; and pharyngeal arch. Orthologous to human GSC (goosecoid homeobox). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (19343015..19345495, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (19323179..19325685, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Goosecoid (Gsc), best known for regulating cellular dynamics in the Spemann organizer, regulates delamination of neuroblasts in the otic vesicle.
Title: Spemann organizer gene Goosecoid promotes delamination of neuroblasts from the otic vesicle.
these data suggest that Lnx-2b maintains the integrity of the ectodermal tissues via suppressing gsc expression which can be driven by the coordinated action of nodal-related factors and Boz.
Title: Lnx-2b restricts gsc expression to the dorsal mesoderm by limiting Nodal and Bozozok activity.
Gsc has dose dependent effects on axis induction and provide new insights into molecularly distinct short- and long-range signaling activities of the organizer.
Title: Short- and long-range functions of Goosecoid in zebrafish axis formation are independent of Chordin, Noggin 1 and Follistatin-like 1b.
FoxA3 and goosecoid cooperate to promote formation of anterior neural tissue by protecting, as early as blastula stage, presumptive anterior neural cells from an irreversible caudalization by the posteriorizing factor Wnt8a.
Title: FoxA3 and goosecoid promote anterior neural fate through inhibition of Wnt8a activity before the onset of gastrulation.

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General gene information

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Markers

gsc (e-PCR), detects polymorphism
- UniSTS:186964

gsc (e-PCR), detects polymorphism
- UniSTS:204669

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior axis specification	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within brain development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dorsal/ventral axis specification	IEP Inferred from Expression Pattern more info
acts_upstream_of_or_within dorsal/ventral pattern formation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural plate anterior/posterior regionalization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuroblast delamination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within otic vesicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein goosecoid

Names: etID102410.17; etID5964.17; zK49F1.1.2 (goosecoid)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.