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Fads6 fatty acid desaturase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303671, updated on 5-Mar-2024

Summary

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Official Symbol
Fads6provided by RGD
Official Full Name
fatty acid desaturase 6provided by RGD
Primary source
RGD:1311950
See related
Ensembl:ENSRNOG00000021380 AllianceGenome:RGD:1311950
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311950
Summary
Predicted to enable oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water. Predicted to be involved in lipid metabolic process. Predicted to be integral component of membrane. Orthologous to human FADS6 (fatty acid desaturase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 569.6), Liver (RPKM 391.8) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fads6 in Genome Data Viewer
Location:
10q32.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (101020921..101037281, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (100522981..100538181, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (103832838..103848035, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene glutamate ionotropic receptor NMDA type subunit 2C Neighboring gene ferredoxin reductase Neighboring gene uncharacterized LOC134480901 Neighboring gene USH1 protein network component sans Neighboring gene otopetrin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fatty acid desaturase 6
Names
fatty acid desaturase domain family, member 6
NP_001100534.1
XP_038942121.1
XP_038942122.1
XP_038942123.1
XP_063125303.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107064.1 → NP_001100534.1  fatty acid desaturase 6

    See identical proteins and their annotated locations for NP_001100534.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A6HKL5, D3ZEE9
    Related
    ENSRNOP00000036480.4, ENSRNOT00000029001.5
    Conserved Domains (2) summary
    pfam00487
    Location:66 → 311
    FA_desaturase; Fatty acid desaturase
    cl00615
    Location:86 → 301
    Membrane-FADS-like; The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    101020921..101037281 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269233.1 → XP_063125303.1  fatty acid desaturase 6 isoform X1

  2. XM_039086195.2 → XP_038942123.1  fatty acid desaturase 6 isoform X4

    Conserved Domains (1) summary
    cl00615
    Location:91 → 197
    Membrane-FADS-like; The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the ...

  3. XM_039086194.2 → XP_038942122.1  fatty acid desaturase 6 isoform X3

    Conserved Domains (1) summary
    cl00615
    Location:95 → 201
    Membrane-FADS-like; The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the ...

  4. XM_039086193.2 → XP_038942121.1  fatty acid desaturase 6 isoform X2

    Conserved Domains (1) summary
    cl00615
    Location:100 → 206
    Membrane-FADS-like; The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the ...
Nucleotide Protein Strain
Heading Accession and Version

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