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Zbtb11 zinc finger and BTB domain containing 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304010, updated on 11-Apr-2024

Summary

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Official Symbol
Zbtb11provided by RGD
Official Full Name
zinc finger and BTB domain containing 11provided by RGD
Primary source
RGD:1308275
See related
Ensembl:ENSRNOG00000001613 AllianceGenome:RGD:1308275
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleoplasm. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human ZBTB11 (zinc finger and BTB domain containing 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 139.1), Spleen (RPKM 125.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
11q12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (58061355..58121768, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (44598694..44652559, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (47079201..47113993, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene SUMO specific peptidase 7 Neighboring gene uncharacterized LOC120095650 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene tRNA methyltransferase 10C, mitochondrial RNase P subunit Neighboring gene PEST proteolytic signal containing nuclear protein Neighboring gene small nucleolar RNA SNORA29 Neighboring gene G protein subunit gamma 5, pseudogene 4 Neighboring gene zinc finger and BTB domain containing 11, opposite strand 1 Neighboring gene uncharacterized LOC134481067 Neighboring gene ribosomal protein L24 Neighboring gene centrosomal protein 97

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107097.1 → NP_001100567.1  zinc finger and BTB domain-containing protein 11

    See identical proteins and their annotated locations for NP_001100567.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473967
    UniProtKB/TrEMBL
    A6IQQ6, D3ZDP9
    Related
    ENSRNOP00000031654.4, ENSRNOT00000034940.5
    Conserved Domains (7) summary
    PRK12387
    Location:556 → 621
    PRK12387; formate hydrogenlyase complex iron-sulfur subunit; Provisional
    COG5048
    Location:666 → 839
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:669 → 754
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:680 → 700
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18202
    Location:195 → 312
    BTB_POZ_ZBTB11; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11)
    pfam13465
    Location:899 → 922
    zf-H2C2_2; Zinc-finger double domain
    pfam17921
    Location:68 → 120
    Integrase_H2C2; Integrase zinc binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    58061355..58121768 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088374.2 → XP_038944302.1  zinc finger and BTB domain-containing protein 11 isoform X1

    Conserved Domains (6) summary
    PRK12387
    Location:556 → 621
    PRK12387; formate hydrogenlyase complex iron-sulfur subunit; Provisional
    COG5048
    Location:695 → 801
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:680 → 700
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18202
    Location:195 → 312
    BTB_POZ_ZBTB11; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11)
    pfam13465
    Location:939 → 962
    zf-H2C2_2; Zinc-finger double domain
    pfam17921
    Location:68 → 120
    Integrase_H2C2; Integrase zinc binding domain

RNA

  1. XR_005491031.2 RNA Sequence

  2. XR_010055958.1 RNA Sequence

  3. XR_010055957.1 RNA Sequence

  4. XR_010055956.1 RNA Sequence

  5. XR_005491033.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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