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Gna14 G protein subunit alpha 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309242, updated on 13-Apr-2024

Summary

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Official Symbol
Gna14provided by RGD
Official Full Name
G protein subunit alpha 14provided by RGD
Primary source
RGD:1308122
See related
Ensembl:ENSRNOG00000014840 AllianceGenome:RGD:1308122
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hg1i; Tieg3
Summary
Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in action potential; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; and phospholipase C-activating dopamine receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Orthologous to human GNA14 (G protein subunit alpha 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 97.2), Kidney (RPKM 40.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q43
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (223141802..223324210)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (213714993..213900083)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (235165775..235347986)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene basic proline-rich protein-like Neighboring gene PWP1 homolog, endonuclein, pseudogene 2 Neighboring gene eukaryotic translation initiation factor 2 subunit beta, pseudogene 1 Neighboring gene vacuolar protein sorting 13 homolog A Neighboring gene forkhead box B2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular properties of muscarinic acetylcholine receptors. Haga T. Proc Jpn Acad Ser B Phys Biol Sci, 2013. PMID 23759942, Free PMC Article
  2. Regulation of phosphoinositide-specific phospholipase C. Rhee SG. Annu Rev Biochem, 2001. PMID 11395409, Free PMC Article
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC105546

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G-protein beta/gamma-subunit complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in phospholipase C-activating dopamine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
guanine nucleotide-binding protein subunit alpha-14
Names
TGFB inducible early growth response 3
guanine nucleotide binding protein, alpha 14
heterotrimeric guanine nucleotide-binding protein 1i

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013151.2 → NP_001013169.1  guanine nucleotide-binding protein subunit alpha-14

    See identical proteins and their annotated locations for NP_001013169.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8J8XRQ3, F1LRE6, Q5EAP4
    Related
    ENSRNOP00000020201.7, ENSRNOT00000020201.8
    Conserved Domains (2) summary
    cd00066
    Location:36 → 349
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:16 → 353
    G_alpha; G protein alpha subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    223141802..223324210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008760288.4 → XP_008758510.1  guanine nucleotide-binding protein subunit alpha-14 isoform X1

    See identical proteins and their annotated locations for XP_008758510.1

    UniProtKB/TrEMBL
    A0A8J8XRQ3, F1LRE6, Q5EAP4
    Conserved Domains (2) summary
    cd00066
    Location:36 → 349
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:16 → 353
    G_alpha; G protein alpha subunit
Nucleotide Protein Strain
Heading Accession and Version

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