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Lama4 laminin subunit alpha 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309816, updated on 13-Apr-2024

Summary

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Official Symbol
Lama4provided by RGD
Official Full Name
laminin subunit alpha 4provided by RGD
Primary source
RGD:1560062
See related
Ensembl:ENSRNOG00000000599 AllianceGenome:RGD:1560062
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560062
Summary
Predicted to enable signaling receptor binding activity. Predicted to be involved in negative regulation of cold-induced thermogenesis. Predicted to act upstream of or within blood vessel development and brown fat cell differentiation. Predicted to be located in basement membrane and neuromuscular junction. Predicted to be active in synaptic cleft. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1JJ. Orthologous to human LAMA4 (laminin subunit alpha 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 457.0), Lung (RPKM 292.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
20q12
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (43946898..44087972)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (42392268..42533347)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (44060715..44201966)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ret finger protein-like 4B Neighboring gene uncharacterized LOC120098940 Neighboring gene M-phase phosphoprotein 6-like Neighboring gene uncharacterized LOC120098941 Neighboring gene family with sequence similarity 229, member B Neighboring gene tubulin, epsilon 1 Neighboring gene cellular communication network factor 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Laminin-8/9 is synthesized by rat glomerular mesangial cells and is required for PDGF-induced mesangial cell migration. Hansen K, et al. Kidney Int, 2003 Jul. PMID 12787401
  2. Deletion of the laminin alpha4 chain leads to impaired microvessel maturation. Thyboll J, et al. Mol Cell Biol, 2002 Feb. PMID 11809810, Free PMC Article
  3. Primary structure, developmental expression, and immunolocalization of the murine laminin alpha4 chain. Iivanainen A, et al. J Biol Chem, 1997 Oct 31. PMID 9346933
  4. The Absence of Laminin α4 in Male Mice Results in Enhanced Energy Expenditure and Increased Beige Subcutaneous Adipose Tissue. Vaicik MK, et al. Endocrinology, 2018 Jan 1. PMID 28973559, Free PMC Article
  5. Early onset photoreceptor abnormalities induced by targeted disruption of the interphotoreceptor retinoid-binding protein gene. Liou GI, et al. J Neurosci, 1998 Jun 15. PMID 9614228, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood vessel development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic cleft ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
laminin subunit alpha-4
Names
laminin, alpha 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309447.1 → NP_001296376.1  laminin subunit alpha-4 precursor

    See identical proteins and their annotated locations for NP_001296376.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    A6KIE5, F1LTF8
    Related
    ENSRNOP00000000737.8, ENSRNOT00000000737.8
    Conserved Domains (7) summary
    smart00282
    Location:853 → 1008
    LamG; Laminin G domain
    cd00055
    Location:187 → 238
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:1483 → 1618
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam06008
    Location:289 → 547
    Laminin_I; Laminin Domain I
    pfam06009
    Location:727 → 854
    Laminin_II; Laminin Domain II
    cl02488
    Location:314 → 523
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl21509
    Location:610 → 798
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    43946898..44087972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107635.1: Suppressed sequence

    Description
    NM_001107635.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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