N Notch [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31293, updated on 10-May-2024

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Summary

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Official Symbol: Nprovided by FlyBase
Official Full Name: Notchprovided by FlyBase
Primary source: FLYBASE:FBgn0004647
Locus tag: Dmel_CG3936
See related: AllianceGenome:FB:FBgn0004647
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 1.1; 16-178; 16-55; anon-EST:Liang-1.12; Ax; CG3936; Chp; clone 1.12; co; Co; CT13012; Dmel\CG3936; dNotch; EG:140G11.1; EG:163A10.2; fa; l(1)3Cb; l(1)Ax; l(1)N; nd; NECD; Nicd; NICD; notch; n[fah]; RICN; shd; spl; swb
Summary: Enables several functions, including WW domain binding activity; histone acetyltransferase binding activity; and transcription coactivator activity. Involved in several processes, including animal organ development; neurogenesis; and oogenesis. Located in several cellular components, including cell surface; cytoplasmic vesicle; and nucleus. Is integral component of plasma membrane. Part of CSL-Notch-Mastermind transcription factor complex. Colocalizes with late endosome and lysosome. Is expressed in several structures, including anterior-posterior subdivision of organism; embryonic/larval circulatory system; gonad; gut section; and larval ventral nerve cord. Used to study adenocarcinoma; brain cancer; central nervous system cancer; and intestinal cancer. Human ortholog(s) of this gene implicated in several diseases, including Adams-Oliver syndrome; Alagille syndrome; CADASIL 1; Hajdu-Cheney syndrome; and adult T-cell leukemia. Orthologous to several human genes including NOTCH1 (notch receptor 1) and NOTCH2 (notch receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

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Location:: 3C7-3C9; 1-2 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (3134870..3172221)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (3028903..3066254)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alternative mechanisms of Notch activation by partitioning into distinct endosomal domains.
Title: Alternative mechanisms of Notch activation by partitioning into distinct endosomal domains.
Scabrous is distributed via signaling filopodia to modulate Notch response during bristle patterning in Drosophila.
Title: Scabrous is distributed via signaling filopodia to modulate Notch response during bristle patterning in Drosophila.
TM2D genes regulate Notch signaling and neuronal function in Drosophila.
Title: TM2D genes regulate Notch signaling and neuronal function in Drosophila.
Intermediate progenitor cells provide a transition between hematopoietic progenitors and their differentiated descendants.
Title: Intermediate progenitor cells provide a transition between hematopoietic progenitors and their differentiated descendants.
Unraveling the features of somatic transposition in the Drosophila intestine.
Title: Unraveling the features of somatic transposition in the Drosophila intestine.
A combination of Notch signaling, preferential adhesion and endocytosis induces a slow mode of cell intercalation in the Drosophila retina.
Title: A combination of Notch signaling, preferential adhesion and endocytosis induces a slow mode of cell intercalation in the Drosophila retina.
Membrane-Anchored Hairless Protein Restrains Notch Signaling Activity.
Title: Membrane-Anchored Hairless Protein Restrains Notch Signaling Activity.
The Clathrin adaptor AP-1 and Stratum act in parallel pathways to control Notch activation in Drosophila sensory organ precursors cells.
Title: The Clathrin adaptor AP-1 and Stratum act in parallel pathways to control Notch activation in Drosophila sensory organ precursors cells.
Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism.
Title: Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism.
The Impact of Drosophila Awd/NME1/2 Levels on Notch and Wg Signaling Pathways.
Title: The Impact of Drosophila Awd/NME1/2 Levels on Notch and Wg Signaling Pathways.

Submit: New GeneRIF Correction See all GeneRIFs (317)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1897 (e-PCR)
- UniSTS:649

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables WW domain binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Malpighian tubule tip cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R1/R6 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R3/R4 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R7 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in anesthesia-resistant memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in asymmetric cell division	TAS Traceable Author Statement more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell dedifferentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye retinal cell programmed cell death	TAS Traceable Author Statement more info	PubMed
involved_in crystal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to insect	IDA Inferred from Direct Assay more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal appendage formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	TAS Traceable Author Statement more info	PubMed
involved_in dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell proliferation involved in Malpighian tubule morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell type specification, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye-antennal disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye-antennal disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber stalk formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in foregut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in formation of a compartment boundary	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem-cell niche homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived egg chamber formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg joint morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived male genitalia morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing margin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lamellocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval lymph gland hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lateral inhibition	TAS Traceable Author Statement more info	PubMed
involved_in leg disc morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in long-term memory	IGI Inferred from Genetic Interaction more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myoblast development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of cell-cell adhesion mediated by cadherin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of compound eye photoreceptor development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lamellocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast fate determination	IDA Inferred from Direct Assay more info	PubMed
involved_in neuroblast fate determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuroblast fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuronal stem cell population maintenance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuronal stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ommatidial rotation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oocyte localization involved in germarium-derived egg chamber formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of crystal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuroblast proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cardioblast cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of developmental process	IEA Inferred from Electronic Annotation more info
involved_in regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic cell cycle	TAS Traceable Author Statement more info	PubMed
involved_in regulation of neuroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to symbiont	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinal cell programmed cell death	TAS Traceable Author Statement more info	PubMed
involved_in second mitotic wave involved in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ precursor cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CSL-Notch-Mastermind transcription factor complex	IDA Inferred from Direct Assay more info	PubMed
part_of CSL-Notch-Mastermind transcription factor complex	IPI Inferred from Physical Interaction more info	PubMed
located_in adherens junction	IMP Inferred from Mutant Phenotype more info	PubMed
located_in apical plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: notch

Names: CG3936-PA; CG3936-PB; N-PA; N-PB; NICD; abruptex; chopped; confluens; dNotch; facet; notchoid; split; strawberry

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

3134870..3172221

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057511.4 → NP_476859.2 notch, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476859.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O97458, P04154, P07207, Q9W4T8

UniProtKB/TrEMBL

M9NE67

Related

FBpp0070483

Conserved Domains (10) summary

smart00004
Location:1476 → 1512

NL; Domain found in Notch and Lin-12

cd00054
Location:449 → 486

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00204
Location:1978 → 2104

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00066
Location:1519 → 1553

Notch; LNR domain

pfam06816
Location:1599 → 1648

NOD; NOTCH protein

pfam07684
Location:1680 → 1731

NODP; NOTCH protein

pfam11936
Location:2627 → 2682

DUF3454; Domain of unknown function (DUF3454)

pfam12796
Location:2022 → 2114

Ank_2; Ankyrin repeats (3 copies)

pfam13857
Location:1970 → 2025

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:2017 → 2048

ANK; ANK repeat [structural motif]
NM_001258581.2 → NP_001245510.1 notch, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245510.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O97458, P04154, P07207, Q9W4T8

UniProtKB/TrEMBL

M9NE67

Conserved Domains (10) summary

smart00004
Location:1476 → 1512

NL; Domain found in Notch and Lin-12

cd00054
Location:449 → 486

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00204
Location:1978 → 2104

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00066
Location:1519 → 1553

Notch; LNR domain

pfam06816
Location:1599 → 1648

NOD; NOTCH protein

pfam07684
Location:1680 → 1731

NODP; NOTCH protein

pfam11936
Location:2627 → 2682

DUF3454; Domain of unknown function (DUF3454)

pfam12796
Location:2022 → 2114

Ank_2; Ankyrin repeats (3 copies)

pfam13857
Location:1970 → 2025

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:2017 → 2048

ANK; ANK repeat [structural motif]